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19,871 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

How safe and effective is oral analgesia for hip fracture patients? – a prospective cohort study

Zehra Abdul Muhammad, Tashfeen Ahmad · 2025 · Journal of the Pakistan Medical Association

Objective: To assess the safety and pain reduction profile of routinely prescribed oral analgesics in patients of hip fracture surgery. Method: The single-centre, prospective, cohort study was conducted from June 2022 to July 2023 at the Aga Khan University Hospital, Karachi and comprised adult patients of either gender with hip fractures. The analgesics prescribed at the time of hospital discharge and 1-week follow-up were recorded along with pain and adverse effects till the 2-week post-discharge follow-up. Pain was recorded using the visual analogue scale, with the target score set at 3/10.

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Negative / Null Result ReportOpen accessDentistry

Addition of bone morphogenetic protein type 2 to ascorbate and -glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon et al. · 2012 · Journal of Applied Oral Science

Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in medium supplemented with ascorbate and -glycerophosphate. MATERIAL AND METHODS: Human ASCs were treated with osteogenic medium in the presence (ASCs+OM+BMP-2) or absence (ASCs+OM) of BMP-2. The alkaline phosphatase (ALP) activity was determined

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Negative / Null Result ReportOpen accessMedicine

Effects of executive function training on balance and auditory-cognitive dual-task performance in adults with and without hearing loss.

Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE

Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog

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Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics

Health-related quality of life and self-related health in patients with type 2 diabetes: Effects of group-based rehabilitation versus individual counselling

Vadstrup Eva S, Frølich Anne, Perrild Hans et al. · 2011 · Health and Quality of Life Outcomes

Abstract Background Type 2 diabetes can seriously affect patients' health-related quality of life and their self-rated health. Most often, evaluation of diabetes interventions assess effects on glycemic control with little consideration of quality of life. The aim of the current study was to study the effectiveness of group-based rehabilitation versus individual counselling on health-related quality of life (HRQOL) and self-rated health in type 2 diabetes patients. Methods We randomised 143 type 2 diabetes patients to either a six-month multidisciplinary group-based rehabilitation programme in

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Negative / Null Result ReportMedicine

Preoperative blood spinal cord barrier biomarker levels correlate with neurological outcome in patients with degenerative cervical myelopathy one year after surgery: a prospective cohort study.

Schmidt TP, Jütten K, Bertram U et al. · 2026 · World neurosurgery

Degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal cord dysfunction and can lead to severe neurological impairment if untreated. While decompressive surgery is the standard treatment, predicting postoperative…

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Negative / Null Result Report

Comparative Assessment of Efficiency and Productivity in Implant Crown Design Generated by Artificial Intelligence, Digital Designers, and Dental Students

Naydenov A, Uzunov T, Kostadinov G et al. · 2026 · Preprint

Abstract Objectives . This study aimed to compare the efficiency and productivity of a three-dimensional Generative Adversarial Network (3DGAN) with experienced digital operators and dental students in the design of screw-retained implant…

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Negative / Null Result ReportMedicine

Statins May Not Reduce Reoperation Rates in Chronic Subdural Hematoma, Regardless of the Use of Antithrombotic Medication.

Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery

Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…

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Negative / Null Result ReportMedicine

Determination of the First Aid Knowledge Level of Teachers Working in Special Education and Rehabilitation Centers Regarding Tooth Avulsion.

Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…

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Negative / Null Result ReportMedicine

Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial.

Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing

Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…

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Negative / Null Result ReportMedicine

Influence of Cavity Design, Bonding-Banding Sequence, and Thermomechanical Loading on the Marginal Adaptation of Class II Resin Composite Restorations.

Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…

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Negative / Null Result ReportMedicine

Causal Impact of Primary Care and Publicly Funded Health Insurance on Catastrophic Health Spending From Climate-Sensitive Diseases in India.

Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy

Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…

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Negative / Null Result ReportOpen accessMedicine

The mediating role of job and life satisfaction in the effect of psychological resilience on employee performance: evidence from the February 6 Kahramanmaraş (Türkiye) earthquakes.

Amırlı H, Gurbanli E · 2026 · BMC psychology

The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…

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Negative / Null Result ReportMedicine

The combined and independent influence of food texture and a 'mindful eating' instruction on eating rate and food intake among Dutch primary schoolchildren.

Jager G, de Wild VWT, Camps G et al. · 2026 · Appetite

Eating rate (ER), the amount of food consumed per unit of time, is a key determinant of food intake, with faster ER associated with larger meal size. Research in adults has shown that both sensory properties like texture, and instructions…

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Negative / Null Result Report

Preoperative Monocyte-to-Lymphocyte Ratio Does Not Discriminate Prolonged Intensive Care Unit Stay After Coronary Artery Bypass Surgery: A Single-Center Retrospective Cohort Study

Peker¹ I, Özdemir¹ O, Kandemir¹ C et al. · 2026 · Preprint

Abstract Aim Prolonged intensive care unit (ICU) stay after coronary artery bypass graft (CABG) surgery is a significant clinical problem associated with increased morbidity, mortality, and healthcare costs. The aim of this study was to…

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Negative / Null Result ReportOpen accessMedicine

Intravascular Imaging for Facilitated Coronary Interventions in DES Era.

Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease

Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…

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Negative / Null Result ReportMedicine

Artificial Liver Support.

Kim HK, Huang DT, Al-Khafaji A · 2026 · Journal of intensive care medicine

Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) both have high mortality rates without liver transplantation. Artificial liver support systems may benefit patients with liver failure, serving as a bridge to…

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Negative / Null Result ReportMedicine

Employing Comics Storytelling to Promote Climate Change Mitigation: An Experimental Study Grounded on the Situational Theory of Public.

Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis

This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…

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