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Browse the failure-mode index

19,871 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Viniferin-Rich Phytocomplex from <i>Vitis vinifera</i> L. Plant Cell Culture Mitigates Neuroinflammation in BV2 Microglia Cells.

Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)

Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…

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Negative / Null Result ReportOpen accessMedicine

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio.

Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics

Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…

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Negative / Null Result ReportOpen accessMedicine

SYNCHRONIZE: Real-World Retrospective Safety Analysis of Patients Treated with OnabotulinumtoxinA for More than One Therapeutic Indication.

Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins

OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…

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Negative / Null Result ReportMedicine

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance.

Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology

The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…

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Negative / Null Result ReportOpen accessMedicine

Body composition and muscle health changes after providing vascular imaging results in older adults: secondary analysis of a randomised controlled trial.

Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research

Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…

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Negative / Null Result ReportMedicine

Theory-guided process evaluation of a multicomponent, technology-based 'SMART Eating' trial among Indian adults: an embedded mixed-methods study.

Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research

We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…

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Negative / Null Result ReportOpen accessMedicine

The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease.

Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…

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Negative / Null Result ReportOpen accessMedicine

MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

Lee KE, Nishi M, Kim J et al. · 2024 · Frontiers in endocrinology

Rationale MG53's known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53's role in the development of type 2 diabetes mellitus. Objective This…

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Negative / Null Result ReportOpen accessMedicine

Autoactivation of the HeLa 9903 test system during a full moon.

Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology

The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…

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Negative / Null Result ReportMedicine

Liquid feeding does not suppress drinking motivation in heavy pigs

Nannoni E, Martelli G, Militerno G et al. · 2024 · Animal Feed Science and Technology.

The experiment aimed to obtain information on the water requirements, drinking behavior and drinking motivation of liquid-fed pigs and was conducted during the hot season. Eighty castrated male pigs (initial body weight: 36 kg) fed a…

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Negative / Null Result ReportMedicine

Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.

Schumacher JD, van Holstein M, Zhou P et al. · 2025 · The Journal of neuroscience : the official journal of the Society for Neuroscience

Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose between options based on information…

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Negative / Null Result ReportOpen accessMedicine

Extracellular Vesicles from Poor-Outcome Intracerebral Hemorrhage Patients Reveal Limited Reparative Potential in a Preclinical Model.

Laso-García F, Díaz-Gamero N, Gallego-Ruiz R et al. · 2025 · International journal of molecular sciences

Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and…

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Negative / Null Result ReportOpen accessMedicine

Enhancing discharge decision-making through continuous monitoring in an acute admission ward: a randomized controlled trial.

Kant N, Garssen SH, Vernooij CA et al. · 2024 · Internal and emergency medicine

In Acute Admission Wards, vital signs are commonly measured only intermittently. This may result in failure to detect early signs of patient deterioration and impede timely identification of patient stability, ultimately leading to…

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Negative / Null Result ReportOpen accessMedicine

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice.

Lavigna G, Grasso A, Pasini C et al. · 2025 · PloS one

There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays…

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Negative / Null Result ReportOpen accessMedicine

CD320 expression is increased in breast cancer stem cells but does not promote their expansion or alter key histone methylation marks.

Carney C, Jenkins L, Jewell C et al. · 2025 · microPublication biology

Several lines of evidence suggest a potential link between stemness and vitamin B12, which contributes to S-adenosylmethionine (SAM) generation and hence methylation-dependent epigenetic control. Here we found that the vitamin B12…

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