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129 real negative results, null findings, and replication failures · Methods Dead-End. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Methods Dead-EndOpen accessMedicine

Minimum Detectable Change and Minimal Clinically Important Difference for the Box and Block Test and Fugl-Meyer Assessment in Moderate to Severe Chronic Stroke.

Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation

Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…

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Methods Dead-EndMedicine

Reproducibility of a Shear Wave Elastography Procedure for Assessing the Piriformis Muscle Stiffness in a Sample of Healthy Young Adults Under Controlled Laboratory Conditions: An Intra- and Inter-Examiner Reliability Study.

Varol U, Kobylarz MD, López-Redondo M et al. · 2026 · Journal of clinical medicine

Background/Objectives : Shear wave elastography (SWE) may provide an objective method for quantifying piriformis muscle stiffness, but its clinical and research use requires evidence that the measurement procedure is reliable. This study…

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Methods Dead-EndMedicine

Measurement error, minimal detectable change, and responsiveness of the Brazilian-Portuguese Reaching Performance Scale for Stroke under usual care conditions.

Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies

Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…

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Methods Dead-EndOpen accessMedicine

Measurement properties of the SARC-T: test-retest reliability, agreement and minimal detectable change in older adults with sarcopenia.

Pedauyé-Rueda B, Maté-Muñoz JL, Hernández-Lougedo J et al. · 2026 · Frontiers in aging

Background The Sarcopenia Optoelectronic Chair-Rise Velocity Test (SARC-T) has been proposed as an instrumented chair-rise measure related to physical function in sarcopenia; however, its test-retest measurement properties have not been…

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Methods Dead-EndMedicine

Evaluation of statistical low-contrast detectability (SLCD) with various confidence levels in CT images and their comparison with human observers.

Anam C, Amilia R, Naufal A et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Purpose This study aims to evaluate statistical low-contrast detectability (SLCD) at multiple confidence levels (CLs) in computed tomography (CT) images and to determine the smallest detectable object sizes compared with human observers…

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Methods Dead-End

Comparative Performance of Gaussian Plume and Backward Lagrangian Stochastic Models for Near-Field Methane Emission Estimation Using a Single Controlled Release Experiment

Upreti A, Shonkwiler K, Riddick SN et al. · 2026 · Preprint

Methane (CH4) is a major component of natural gas and a potent greenhouse gas. Increasing atmospheric methane concentrations are attributed to emissive anthropogenic activities by an average of 13 ppb per yr since 2020 and are linked to a…

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Methods Dead-EndMedicine

Long-term Assessment of Oral Health-Related Quality of Life Following Surgical Removal of Mandibular Third Molar with Advanced Platelet-rich Fibrin: a Single-blinded Randomized Controlled Trial.

Starch-Jensen, Giordano, Alsadi et al. · 2026 · Journal of oral & maxillofacial research

The aim of this single-blinded randomized controlled trial was to test the hypothesis of no difference in long-term oral health-related quality of life following surgical removal of an impacted mandibular third molar with advanced…

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Methods Dead-EndOpen accessPhysiology

Meta-Analyses of Association Between BRAFV600E Mutation and Clinicopathological Features of Papillary Thyroid Carcinoma

Qing Zhang, Shao-zheng Liu, Qing Zhang et al. · 2016 · Cellular Physiology and Biochemistry

Background/Aims: The function of BRAF V600E as a prognostic biomarker continues controversial by reason of conflicting results in the published articles. Methods: A systematical literature search for relevant articles was performed in PubMed, Cochrane Library, Google Scholar, Medline and Embase updated to August 5, 2015. The Chi-square test and I2 were employed to examine statistical heterogeneity. Pooled ORs with their corresponding 95% confidence intervals (95%CIs) were calculated to assess the relationship between clinicopathological features and BRAFV600E mutation. Subgroup analyses by eth

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Methods Dead-EndMedicine

A novel engineered vector for TA cloning of PCR products.

Samiei A, Najafabadi ZH, Akbari N et al. · 2026 · Journal of applied genetics

INTRODUCTION: Optimized vectors are crucial in modern molecular biology because they greatly enhance the efficiency of the DNA cloning procedure. This study aimed to design a novel engineered vector containing an HphI cassette to enhance…

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Methods Dead-EndOpen accessMedicine

Comparison of Three Behavior Modification Techniques for Management of Anxious Pediatric Dental Patients Aged 4-6 Years during Cavity Preparation Using Airotor: A Randomized Controlled Trial.

Safoora AK, Vadakkepurayil K, Santhakumar M · 2026 · International journal of clinical pediatric dentistry

Background and objectives Dental anxiety is frequently observed in children and often poses a significant challenge to providing effective and high-quality dental care. Managing a child's anxiety in the clinical setting is a critical…

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Methods Dead-EndOpen accessMicrobiology

Isotope Ratio Outlier Analysis (IROA) for HPLC–TOFMS-Based Metabolomics of Human Urine

Fadi Fadil, Claudia Samol, Raffaela S. Berger et al. · 2022 · Metabolites

Metabolic fingerprinting by mass spectrometry aims at the comprehensive, semiquantitative analysis of metabolites. Isotope dilution, if successfully implemented, may provide a more reliable, relative quantification. Therefore, the 13 C labeled yeast extract of the IROA TruQuant kit was added as an internal standard (IS) to human urine samples measured in full-scan mode on a high-performance liquid chromatography-time-of-flight mass spectrometer (HPLC–TOFMS) system. The isotope ratio approach enabled the analysis of 112 metabolites. The correlation with reference data did not improve significan

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Methods Dead-EndOpen accessMedical emergencies. Critical care. Intensive care. First aid

Procedural training models among emergency medicine residency programs

Leslie Bilello, Andrew Ketterer, Shaked Yarza et al. · 2021 · Clinical and Experimental Emergency Medicine

Objective Optimal training methods remain controversial for rarely performed emergency procedures. Previous research has failed to demonstrate the superiority or inferiority of live anesthetized animal models (LAA) as compared to other modalities. Most of the data on LAA use comes from military contexts; less information is available for civilian emergency medicine (EM) training. We sought to characterize the prevalence of LAA use among civilian EM residency programs and reasons for its use or discontinuation. Methods Survey study of program directors of EM residency programs accredited by the

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Methods Dead-EndMedicine

The Dose-Response Relationship of an Exercise-Based Injury Prevention Program: A Secondary Analysis of a Randomized Controlled Trial on Athletics (Track-and-Field) Athletes Over a 39-Week Follow-Up.

Iatropoulos S, Dandrieux PE, Navarro L et al. · 2024 · Scandinavian journal of medicine & science in sports

Despite exercise-based injury prevention programs (EIPPs) being widely researched and used, several randomized controlled trials (RCTs) have failed to show their protective effect on injury risk. This is potentially due to…

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