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Browse the failure-mode index

20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Community-level Monitoring of Antimicrobial Resistance following Mass Administration of Azithromycin to Reduce Child Mortality in Côte d’Ivoire: Results from Two Rounds of Surveillance

Dulli L, Gbonon V, Touré F et al. · 2026 · Preprint

Background Mass Drug Administration (MDA) of azithromycin for the elimination of trachoma and, more recently, for the reduction of child mortality, are public health strategies shown, with mixed results, to contribute to the development of…

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Negative / Null Result ReportMedicine

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study.

Normand-Gravier T, Solsona R, Bertrand-Gaday C et al. · 2026 · Experimental physiology

Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both…

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Negative / Null Result ReportMedicine

Effects of providing access to a cycling exergaming platform on cardiorespiratory fitness and cardiometabolic health in adolescents: a randomised, controlled trial.

Berg J, Wang AI, Madssen E et al. · 2026 · Scientific reports

Insufficient physical activity (PA) among adolescents has deleterious consequences for their health. Exergaming, which combines exercise with gaming, is enjoyable, but the long-term effects of exergaming on adolescent health remain poorly…

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Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

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Negative / Null Result ReportMedicine

Are gaps in the time of submissions and approvals of new drugs between Health Canada and the Food and Drug Administration related to therapeutic value? A cross-sectional study.

Lexchin J · 2026 · Health policy (Amsterdam, Netherlands)

Background Health Canada is proposing to use decisions by foreign regulators in approving new drugs to speed up their marketing. Objectives To investigate the length of gaps in submissions to and approvals by Health Canada compared to the…

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Negative / Null Result ReportMedicine

Do potentially traumatic events experienced by people in one's social circle affect one's own mental health and emotional support? Findings from a prospective population-based study.

van der Velden PG, Contino C, Kempe S et al. · 2026 · Acta psychologica

Background Adults may have individuals in their social circle who were recently exposed to potentially traumatic events (PTEs). The present study aims to examine if these adults are at increased risk for mental health problems and reduced…

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Negative / Null Result ReportMedicine

Optimizing Necrotizing Otitis Externa Management: The Role of PET-CT in Antibiotic Stewardship.

Zammit M, Davies T, Youssef A · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To optimize antibiotic regimens in necrotizing otitis externa (NOE) and skull base osteomyelitis (SBO) and evaluate the role of positron emission tomography-computed tomography (PET-CT) in disease monitoring. Study design A…

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Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

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Negative / Null Result ReportMedicine

DNAemia Thresholds to Discontinue Antivirals in Preemptive Management for Cytomegalovirus Seropositive Recipients After Kidney Transplantation.

Miehrig AH, Foresto RD, Tedesco-Silva H et al. · 2026 · Transplantation

Background Treatment of cytomegalovirus (CMV) after kidney transplantation aims to achieve cessation of viral replication; however, the use of highly sensitive DNA assays creates uncertainty regarding the optimal DNAemia threshold for…

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