20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Singh N, Petrakis I, Pittman B et al. · 2025 · Journal of psychopharmacology (Oxford, England)
Background There is growing interest in developing pharmacological agents to reverse alcohol (ethanol) intoxication, akin to naloxone for opioids. GABAergic modulation offers a potential pathway for reversing alcohol effects, specifically…
View details →Li ZY, Peng SY, Li FL et al. · 2026 · World journal of clinical oncology
Pancreatic ductal adenocarcinoma remains largely refractory to current immunotherapies due to a profoundly immunosuppressive tumor microenvironment dominated by regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and…
View details →Huang L, He J · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2) plays pivotal roles in cellular proliferation, survival, and differentiation of several malignancies. Upper tract urothelial carcinoma (UTUC) is a relatively rare malignancy. The…
View details →Anzures G, Mildort M, Valenzuela KPM · 2026 · Developmental psychobiology
Despite the early emergence of differences in processing own- and other-race faces, examinations of the corresponding neural correlates prior to adulthood remain limited. The present study examined 5- to 10-year-olds' and adults' P100 and…
View details →Trube J, Sabina M, Khanani A et al. · 2025 · American heart journal plus : cardiology research and practice
Introduction Inflammation is a key risk factor in cardiovascular diseases, such as atherosclerosis, and has been linked to increased mortality following myocardial infarction. While inflammation promotes tissue repair, sustained…
View details →Zacharia GS, Ashraf MH, Sosa F et al. · 2025 · World journal of gastrointestinal pharmacology and therapeutics
Metabolic dysfunction-associated steatotic liver disease (MASLD), recognized as the most prevalent liver disease worldwide and a leading cause of liver transplantation, is closely associated with type 2 diabetes, cardiovascular disease,…
View details →Höglinger G, Vandenberghe W, Woitalla D et al. · 2026 · BMJ neurology open
Background Preclinical evidence suggests targeting the mid-region of tau as a viable therapeutic strategy in diseases such as progressive supranuclear palsy (PSP): a rare, fatal, neurodegenerative tauopathy with no currently approved…
View details →Sitbon O, Boucly A, Weatherald J et al. · 2025 · The European respiratory journal
Over the past three decades, several drugs have been developed to target three major dysfunctional pathways in pulmonary arterial hypertension (PAH), including the prostacyclin, endothelin and nitric oxide pathways. Despite these advances,…
View details →Riguzzi M, Verweij L, Naef R · 2025 · Intensive & critical care nursing
Objectives This study aims to demonstrate that family satisfaction with intensive care and decision-making is independent of sociodemographic family member and patient characteristics and the patient outcomes of mortality and length of…
View details →Shahin MM, Shashi KK, Shaikh R · 2025 · Cardiovascular and interventional radiology
Purpose This paper introduces a novel technique, cervical lymphangiogram, involving intranodal lymphangiogram through cervical lymph nodes. We will discuss our preliminary experience regarding the technique, safety, and applications,…
View details →Oar EL, Rapee RM, Lavell CH et al. · 2025 · The British journal of clinical psychology
Objectives Exposure therapy is a well-established treatment for anxiety disorders in children; however, many young people do not fully respond to treatment. Advances in strategies to enhance extinction learning from exposure therapy are…
View details →Giovannenze F, Del Vecchio P, Frondizi F et al. · 2025 · The Journal of hospital infection
Background Antimicrobial stewardship (AMS) programmes aim to enhance antibiotic prescription quality, reduce antibiotic use, and combat multi-drug-resistant pathogens. However, the optimal AMS intervention for different clinical settings…
View details →Walker-Pizarro N, Chan JL, Yu J et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)
Clinical vignette A 59-year-old man with essential tremor (ET) and bilateral symptoms initially underwent left thalamic MRI-guided focused ultrasound (MRgFUS) at an outside institution to address tremor in the right upper extremity.…
View details →Harkins P, Cowley S, Conway R · 2025 · Journal of inflammation research
There is currently no gold standard diagnostic test or validated serological biomarker to monitor disease activity or inform disease prognostication in isolated Polymyalgia Rheumatica (PMR). This presents significant challenges as the…
View details →Steensbæk MT, Yousef S, Bahuet AR et al. · 2026 · Acta anaesthesiologica Scandinavica
Background Closed reduction of distal radius fractures is painful, and current analgesic strategies may be inadequate. Ultrasound-guided lateral infraclavicular brachial plexus block may offer complete analgesia and muscle relaxation,…
View details →Santiago MDS, Wu GY · 2026 · Journal of clinical and translational hepatology
Alpha-1 antitrypsin deficiency (AATD) is an autosomal codominant genetic disorder caused by mutations in the SERPINA1 gene. It results in reduced circulating levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor (PI) primarily…
View details →Nawrocki PS, Rau BT · 2025 · Cureus
This report describes a case of hypokalemia-induced hemiplegia and altered mental status masquerading as an acute large vessel occlusion (LVO) stroke, and provides a brief discussion of stroke mimics. An air ambulance was dispatched to…
View details →Wincewicz D · 2025 · Brain research
Pinpointing the bidirectional relationship between psychiatric and cardiovascular disorders holds the potential to tailor therapy and apply concepts of personalized treatment. Recent findings from both basic and clinical studies indicate…
View details →Paavonen J, Brunham RC · 2024 · Frontiers in cellular and infection microbiology
Localized provoked vulvodynia (LPV), also called vulvar vestibulitis or provoked vestibulodynia, is a major cause of dyspareunia that severely impacts sexual health. At the tissue level, lymphocytic inflammation and hyperinnervation are…
View details →Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics
The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…
View details →Linz MS, Wang T, Friberg J et al. · 2026 · Trauma case reports
Introduction Traumatic hemipelvectomy is a rare operation, often performed for injuries caused by a high force mechanism such as a traffic or industrial accident, and often fatal. Most often performed emergently, here we report a traumatic…
View details →Wu TC, Lin CC · 2025 · Cancer prevention research (Philadelphia, Pa.)
The study by Downs and colleagues targets patients with non-muscle-invasive bladder cancer (NMIBC) to explore secondary/tertiary cancer prevention strategies. Utilizing a "window-of-opportunity" design, erlotinib was evaluated for its…
View details →Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…
View details →Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery
OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…
View details →Regidor E, Dionigi C, Ghoraishi M et al. · 2026 · Journal of periodontal research
Aims To evaluate the adjunctive effect of enamel matrix derivative (EMD) in the reconstructive surgical therapy of peri-implantitis. Methods Forty subjects (44 implants) affected by peri-implantitis (PPD ≥ 5 mm, positive BOP/SOP,…
View details →Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →Niazi SK · 2024 · International journal of molecular sciences
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…
View details →Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine
Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…
View details →Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research
Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…
View details →Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society
Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…
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