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19,859 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of supplementing crude protein to feedlot bison heifers using canola meal or wheat-based distillers' grains with solubles on feed intake, performance and carcass traits.

Alcivar de Lucca J, McKinnon JJ, Feist MS et al. · 2025 · Translational animal science

This study evaluated how varying crude protein levels in rations that incorporated canola meal or wheat-based dried distillers' grains with solubles as alternative protein sources affected growth performance, carcass traits, and liver…

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Negative / Null Result ReportOpen accessMedicine

A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis.

de Jager V, Mockeliunas L, You H et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background In vitro, meropenem is shown to restore the activity of rifampicin in rifampicin-resistant Mycobacterium tuberculosis strains. This phase 2a trial aimed to determine if addition of rifampicin increases the early bactericidal…

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Negative / Null Result ReportMedicine

The Effect of 6 Months of Dietary Counselling on Sleep Outcomes Among Patients With Cardiovascular Diseases: A Randomised Controlled Trial.

Verkaar AJCF, van Damme I, van Veldhuisen ER et al. · 2026 · Journal of sleep research

Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted…

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Negative / Null Result ReportMedicine

Volume-Stable Collagen Matrix With or Without Platelet-Rich Fibrin Impregnation for Multiple Gingival Recessions: A Randomized Clinical Trial.

Magrin GL, Michels R, Gil ACK et al. · 2026 · Journal of periodontal research

Aim This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the…

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Negative / Null Result ReportMedicine

Cannabigerol and cannabidiol differ in their ability to affect the AhR/CYP1A pathway in vitro.

Vrba J, Havlasek J, Dostalova K et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Cannabidiol (CBD) is known to activate aryl hydrocarbon receptor (AhR) and expression of cytochromes P450 (CYP) 1A. This study examined the effect of cannabigerol (CBG) on the AhR/CYP1A pathway in HepG2 cells, human hepatocytes, and normal…

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Negative / Null Result ReportMedicine

Comparative analysis of nucleic acid delivery systems based on benzimidazolium surfactants: impact of auxiliary lipids on lipoplex internalization and functional gene delivery in cancer cells.

Kuznetsova DA, Kuznetsov DM, Lyubina AP et al. · 2026 · Biochimica et biophysica acta. Biomembranes

The design of effective non-viral nucleic acid delivery systems based on cationic amphiphilic compounds remains a major challenge in biomedical research. In this study, cationic benzimidazolium surfactants (BI-n) and cationic liposomes…

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Negative / Null Result ReportMedicine

Pimobendan in Heart Failure With Preserved Ejection Fraction and Right Ventricular-Pulmonary Arterial Uncoupling - A Randomized Clinical Trial.

Nakagawa A, Matsuoka Y, Seo M et al. · 2026 · Circulation journal : official journal of the Japanese Circulation Society

Background Patients with heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV)-pulmonary arterial (PA) uncoupling, as assessed by a decrease ratio of tricuspid annular plane systolic excursion (TAPSE) to PA…

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Negative / Null Result ReportMedicine

Simvastatin Treatment in Patients with Liver Cirrhosis: a Phase II Randomized Placebo Controlled Trial Shows Reduction in IL-6 Levels.

Hussain SK, Ayoub WS, Cruz-Correa M et al. · 2026 · Cancer prevention research (Philadelphia, Pa.)

Hepatocellular carcinoma (HCC) is a lethal cancer with rising burden. Few clinical trials have evaluated preventive strategies for HCC in high-risk patients with liver cirrhosis. Observational studies show statins are associated with…

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Negative / Null Result ReportMedicine

Effects of Experimental Intermittent Theta Burst Stimulation on Negative Symptoms of Schizophrenia: A Double-Blind Sham-Controlled Study.

Kumar N, Prasad S, Srivastava MVP et al. · 2026 · The Journal of clinical psychiatry

Background: Negative symptoms remain among the most debilitating and treatment-resistant features of schizophrenia. Repetitive transcranial magnetic stimulation, particularly intermittent theta burst stimulation (iTBS), is emerging as a…

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Negative / Null Result ReportMedicine

Inpatient Robotic Therapy for Stroke Survivors With Severe Upper Limb Impairments: A Randomized Controlled Trial.

Cowan C, Harmon EY, Melewski M et al. · 2026 · The American journal of occupational therapy : official publication of the American Occupational Therapy Association

Importance Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important to advancing poststroke treatment and recovery. Objective To determine whether UE RT…

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Negative / Null Result ReportMedicine

Efficacy and tolerability of metformin as an adjuvant therapy in patients with relapse-remitting multiple sclerosis receiving interferon Beta 1a: A randomized pilot trial.

Abdelgaied MY, Abdelgawad O, Rashad MH et al. · 2026 · Journal of neuroimmunology

Background Neurodegeneration and inflammation can accelerate the demyelination process in multiple sclerosis (MS). We aimed to investigate the efficacy and tolerability of metformin as an add-on treatment to interferon Beta 1a (IFNβ-1a) in…

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Negative / Null Result ReportOpen accessMedicine

Thermal Safety of Forced-Air Warming During Balloon Occlusion in Isolated Perfusion Chemotherapy: A Prospective Feasibility Study Using Multisite Temperature Monitoring.

Aust H, Kranke P, Torossian A et al. · 2026 · Cancers

Background Isolated Perfusion Chemotherapy (IPC) with balloon occlusion creates transient ischemic tissue compartments while patients remain exposed to significant perioperative heat loss. Active warming during these phases is commonly…

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Negative / Null Result ReportMedicine

Enhancing Potato (Solanum tuberosum L.) Production in a Semi-arid Environment in Morocco Using Subsurface Drip Irrigation and Other Water-Saving Strategies

Kretzschmar HA, Abouabdillah A, Bouabid R et al. · 2026 · Potato Res..

The Fès-Meknès region in Morocco is characterized by a typical Mediterranean climate and the cultivation of water-demanding, locally well-established cash crops, such as potato (Solanum tuberosum L.). Therefore, this region is likely to…

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Negative / Null Result ReportMedicine

Short-Chain Fatty Acids May Promote Regulatory T Cell Induction to Enhance Maternal Immune Tolerance in Early Pregnancy.

Takahashi K, Kawagoe J, Takehara I et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)

This study examined whether oral administration of individual short-chain fatty acids (SCFAs) alters Treg- and Th17-related immune parameters during the peri-implantation period in pregnant mice. Using a mouse model, the effects of SCFAs…

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Negative / Null Result ReportMedicine

Operative management of supination-external rotation type trimalleolar equivalent ankle fractures: reassessing the role of deltoid ligament repair and impact of posterior malleolar fixation on postoperative syndesmotic widening.

Choi JY, Yu OJ, Yun JY et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose The role of deltoid ligament (DL) repair in supination-external rotation (SER)-type trimalleolar equivalent ankle fractures (TEAFs) remains controversial. Additionally, it remains unclear whether posterior malleolar fixation alone…

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Negative / Null Result ReportMedicine

Cytotoxicity assessment of Tera Harz TC-85DAC direct-printed clear aligners and effects of post curing time.

Peanchitlertkajorn S, Makkasaman K, Neoh SP et al. · 2026 · Journal of the World federation of orthodontists

Background To evaluate the cytotoxicity of direct 3D-printed aligners fabricated from Tera Harz TC-85DAC resin (TC) compared with conventional thermoformed aligners, and to investigate the effect of different post curing durations on TC…

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Negative / Null Result ReportMedicine

How changes to frequency of treatment and mode of treatment improved paediatric speech-language pathology services: A pragmatic clinical trial.

Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology

Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…

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