19,859 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Okuno-Ozeki N, Kohama Y, Taguchi H et al. · 2025 · Scientific reports
Reducing salt intake is crucial for managing hypertension. While efforts to reduce salt intake are based on the assumption that people have a preference for salt, it is also important to acknowledge that there is an aversion to high levels…
View details →Eremichev R, Nikolaeva N, Khandokhin M et al. · 2025 · Biology
Recent discovery of menstruation in the Egyptian spiny mouse ( Acomys cahirinus) highlighted this species as a feasible model for the study of menstrual cycle physiology. However, reports on active menstrual bleeding in this animal were…
View details →Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open
Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…
View details →Saito A, Terai H, Kim TJ et al. · 2024 · Cancer medicine
Background Companion diagnostic tests play a crucial role in guiding treatment decisions for patients with non-small cell lung cancer (NSCLC). The Oncomine Dx Target Test (ODxTT) Multi-CDx System has emerged as a prominent companion…
View details →Awaly M, Norton M, Ahmed D et al. · 2025 · Cureus
Midline laparotomy remains essential in gynecological oncology, and rectus sheath catheters (RSCs) are commonly used for postoperative analgesia. We report the case of a 46-year-old woman who underwent midline laparotomy for a suspected…
View details →Salimkhanov R, Utkina M, Bagirova H et al. · 2025 · Frontiers in endocrinology
Multiple endocrine neoplasia type 1 (MEN-1; OMIM 131100) is a rare, autosomal dominant syndrome caused by heterozygous inactivating mutations in the MEN1 tumor suppressor gene (11q13; OMIM 613733). MEN-1 is characterized by polyglandular…
View details →Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences
Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…
View details →Vinyard DJ, Govindjee G · 2024 · Photosynthesis research
Photosystem II (PSII) uses light energy to oxidize water and to reduce plastoquinone in the photosynthetic electron transport chain. O 2 is produced as a byproduct. While most members of the PSII research community agree that O 2…
View details →Halalsheh H, Odeh N, Kiswani A et al. · 2026 · Cancers
Background Accurate staging is vital for optimizing outcomes in pediatric rhabdomyosarcoma (RMS). While [ 18 F]-FDG PET/CT is increasingly utilized, its specific impact on clinical management and its prognostic value compared to…
View details →Ito S, Takano C, Hoque SA et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect…
View details →Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters
The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…
View details →Arcieri F, Vasta A, Sorrenti S et al. · 2026 · Journal of clinical medicine
Background: Congenital cytomegalovirus (cCMV) infection is a leading cause of neonatal morbidity. This retrospective study aimed to evaluate the efficacy of valacyclovir in reducing vertical transmission after primary maternal CMV…
View details →Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology
Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…
View details →K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM
Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…
View details →Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…
View details →Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology
Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…
View details →Sachetto ATA, Mackman N · 2024 · Research and practice in thrombosis and haemostasis
Background Tissue factor (TF) is the primary cellular initiator of the blood coagulation cascade. Increased levels of TF expression on circulating monocytes or on extracellular vesicles (EVs) are associated with thrombosis in a variety of…
View details →De Ryst JE, Bergström S, Mravinacova S et al. · 2026 · Fluids and barriers of the CNS
Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery. This study…
View details →Liu D, Yan Q, Qin X et al. · 2025 · Biochimica et biophysica acta. Bioenergetics
Photosystem I (PSI) is a large membrane photosynthetic complex that harvests sunlight and drives photosynthetic electron transport. In both green algae and higher plants, PSI's ultrafast energy transfer and charge separation kinetics have…
View details →S R S, Holla R, Rao M et al. · 2026 · The Indian journal of medical research
Background and objectives The gold standard for diagnosing malaria is peripheral smear. Histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are particularly used for P. falciparum (pf) infections. These tests are easily…
View details →N R, Sivamani H, Sivaraman A et al. · 2024 · Cureus
This report presents the case of vaginal foreign body (FB) in a seven-year-old girl with recurrent genitourinary symptoms that went unrecognized for two years. Despite thorough evaluation including MRI, cystourethroscopy, and several…
View details →Zehner KM, Salib A, Sanchez JG et al. · 2026 · Journal of hand surgery global online
Purpose Carpal tunnel syndrome may be considered for carpal tunnel injection (CTI). Ultrasound (US) guidance has been proposed to improve CTI accuracy, but the trend across the years, factors associated with utilization, and outcomes are…
View details →Almutairi M, Alalmaee R, Alamer E et al. · 2026 · Journal of clinical tuberculosis and other mycobacterial diseases
Background Tuberculosis (TB) is a major global health issue, particularly among HIV-positive individuals. In Saudi Arabia, the incidence has declined to 8.4 per 100,000 but remains a concern among high-risk groups. Extrapulmonary TB,…
View details →Zheng J, Zhou Y, Fuentes RJ et al. · 2024 · Preprint
The motor protein Prestin found in the outer hair cells (OHCs) of the inner ear is responsible for producing high sensitivity and sharp frequency selectivity for mammalian hearing. Some studies have suggested that Prestin could serve as a…
View details →Zhang P, Guo Y, Xu Y et al. · 2025 · Talanta
The identification of natural active compounds is typically a cumbersome and time-intensive process due to the necessity for elaborate sample pretreatment, leading to inefficiencies. Although recent advancements have introduced methods for…
View details →Britnell JA, Palme R, Kerley GIH et al. · 2024 · Functional Ecology
Steroid hormones, especially glucocorticoids (GCs), are widely used to assess physiological responses to stressors. As steroid hormones are heavily metabolised prior to excretion, it is essential to validate enzyme immunoassays (EIAs) for…
View details →McDaniel CS, Vannette RL, Arroyo-Flores A et al. · 2024 · Preprint
ABSTRACT Fire blight is a devastating disease affecting pome fruit trees that is caused by Erwinia amylovora and leads to substantial annual losses worldwide. While antibiotic-based management approaches like streptomycin can be effective,…
View details →Anez SG, Flail DB, Burkhart EP et al. · 2025 · Journal of natural products
Monotropa uniflora L. ("ghost pipe"), is a North American traditional medicinal plant which has recently seen an increase in consumption nationwide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora,…
View details →Håkansson G, Grossmann KR, Ådén U et al. · 2024 · Preprint
Aim Neonatal hypoxic-ischemic encephalopathy (HIE) injures the infant brain during the basic formation of the developing functional connectome. This study aimed to investigate long-term changes in the functional connectivity (FC) networks…
View details →Strotzer QD, Nieberle F, Kupke LS et al. · 2024 · Radiology
Background Large language models have already demonstrated potential in medical text processing. GPT-4V, a large vision-language model from OpenAI, has shown potential for medical imaging, yet a quantitative analysis is lacking. Purpose To…
View details →