20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Nygaard B, Jensen CZ, Jorsal M et al. · 2025 · European thyroid journal
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the…
View details →Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
View details →Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science
We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…
View details →Martin EL, Adarve-Rengifo I, Siddons SR et al. · 2026 · Ecology and evolution
Terrestrial leaf litter can release chemical compounds into the water, creating a solution called "leachate" that can have direct and indirect impacts on freshwater organisms. In this study, we investigated the direct effects of leaf…
View details →Forde G, Ifantides KB, Mayadev A et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended…
View details →Anderbrant O, Huynh H, Isaksson A et al. · 2025 · Journal of Applied Entomology
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran…
View details →Xicota L, Cheng R, Barral S et al. · 2025 · Preprint
ABSTRACT Introduction Polygenic risk scores (PRS) have been used to assess an individual’s risk for various diseases, including Alzheimer’s disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy…
View details →Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology
The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…
View details →Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications
Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…
View details →Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal
Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…
View details →Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…
View details →Prasifka JR, Fugate KK, Hulke BS · 2025 · Crop Science.
Variation in the quality, quantity, or accessibility of nectar and pollen within plant species is a potential target for plant breeding, both to enhance pollination and to support nutritional needs of pollinators. A biparental population…
View details →Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology
Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…
View details →Park SJ, Manson JE, Kim E et al. · 2026 · Thrombosis and haemostasis
Epidemiological and experimental studies suggest cocoa flavanols and multivitamin-multimineral (MVM) supplements may confer arterial vascular benefits. However, their effects on clinical venous thromboembolic events have been infrequently…
View details →McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science
Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…
View details →Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…
View details →Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition
For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…
View details →Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
View details →Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache
Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…
View details →Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology
Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…
View details →Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences
The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…
View details →Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…
View details →Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins
OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…
View details →Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology
The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…
View details →Kornienko TE, Chepanova AA, Kolobenko MV et al. · 2026 · Current issues in molecular biology
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…
View details →Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research
Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…
View details →Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research
We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…
View details →Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today
Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…
View details →Robinson HL, Banks ML · 2026 · ASPET discovery
Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…
View details →Rahimi A, Fatehi F, Rafiee H et al. · 2026 · Veterinary medicine and science
Background Beet vinasse (VIN), a by-product of sugar beet processing, is rich in non-protein nitrogen (NPN), potassium, and prebiotic compounds, offering potential as a feed additive to enhance dairy cow performance while reducing…
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