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Browse the failure-mode index

20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Evaluating Food and Drug Administration approved gastrointestinal cancer drugs: clinical benefit and trial endpoints over the past two decades.

Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist

Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…

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Negative / Null Result ReportMedicine

Patient-reported outcomes with paclitaxel and ramucirumab switch maintenance in advanced gastroesophageal cancer: A secondary endpoint of the ARMANI phase 3 trial.

Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)

Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…

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Negative / Null Result ReportMedicine

Evaluating patients on immune checkpoint inhibitors for cardiac adverse events: The EPICC study.

Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…

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Negative / Null Result ReportOpen accessMedicine

Platelet-rich fibrin matrix as treatment for complex anal fistulae: A 3-year experience at a tertiary centre.

Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…

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Negative / Null Result ReportOpen accessMedicine

The efficacy of nutritional phytochemical compounds in improving cognition.

Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology

The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…

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Negative / Null Result ReportMedicine

Randomized clinical trial of duplex ultrasound surveillance after endovascular therapy for chronic limb-threatening ischemia.

Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery

Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…

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Negative / Null Result ReportMedicine

Cryotherapy following total knee replacement.

Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews

Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…

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Negative / Null Result ReportMedicine

Association of Mechanical Circulatory Support and Cardiac Catheterization Laboratory Procedural Volumes With Outcomes of Cardiogenic Shock.

Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology

Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…

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Negative / Null Result ReportMedicine

The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial.

Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports

Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…

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Negative / Null Result ReportMedicine

Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.

Corbett A, Taylor R, Llewellyn D et al. · 2025 · Journal of the American Medical Directors Association

Objectives Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with…

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Negative / Null Result ReportMedicine

Tadalafil Use in Cardiovascular Disease.

Kallash M, Frishman WH · 2025 · Cardiology in review

Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been…

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Negative / Null Result ReportMedicine

Immediate versus staged complete revascularization in patients presenting with multivessel disease and ST- or non-ST-segment elevation acute coronary syndrome.

Elscot JJ, Kakar H, den Dekker WK et al. · 2025 · International journal of cardiology

Background Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease.…

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Negative / Null Result ReportOpen accessMedicine

Quality of Recovery after Intraoral Surgery: Total Intravenous Anaesthesia versus Sevoflurane: A Randomised Controlled Trial.

Šitum I, Mihaljević S, Blivajs I et al. · 2026 · Acta stomatologica Croatica

Objectives To compare the quality of recovery between total intravenous anaesthesia (TIVA) with propofol and balanced inhalational anaesthesia with sevoflurane in patients undergoing intraoral surgical procedures. Materials and methods We…

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Negative / Null Result ReportMedicine

Extended pelvic lymphadenectomy and rectal cancer: An umbrella review.

Villanova V, Martinino A, Stanzani E et al. · 2025 · Surgical oncology

Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard…

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Negative / Null Result ReportOpen accessMedicine

Will DANCAVAS be the most important screening trial in the last 50 years?

Dixit NM, Chau E, Schaefer S · 2024 · American journal of preventive cardiology

Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS) involved men aged 65-74 years old who were randomized to an invitation to undergo…

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Negative / Null Result ReportMedicine

Real-time qPCR evaluation of amino acids buffered sodium hypochlorite gel as an adjunct to non-surgical periodontal treatment: a randomized clinical trial.

Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports

This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…

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Negative / Null Result ReportMedicine

Mandibular Response in Class II Division 1 Growing Subjects: Clear Aligners vs. Rapid Maxillary Expansion Therapy. A Controlled Pilot Study.

Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research

Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…

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Negative / Null Result ReportOpen accessMedicine

Randomized Controlled Pilot Study of Transcutaneous Electrical Nerve Stimulation for Acute Back Pain in Emergency Department Patients.

Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine

Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…

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Negative / Null Result ReportMedicine

Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial.

Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research

Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…

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Negative / Null Result ReportMedicine

Twelve-month outcomes after open bleb revision for Preserflo<sup>®</sup> microshunt bleb failure in refractory glaucoma patients.

Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…

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Negative / Null Result ReportOpen accessMedicine

Use of vericiguat in the VICTOR trial: a study that is difficult to interpret.

Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…

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