e-ISSN: Pending

Browse the failure-mode index

19,859 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of preoperative screw planning and X-ray simulation for iliosacral and transsacral screw placement.

Hoskens S, Bamps K, Herteleer M · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Objectives The percutaneous placement of iliosacral (IS) and transsacral (TS) screws has become a standard practice for the treatment of pelvic fractures. Due to the complex sacral anatomy, accurate screw placement is essential to avoid…

View details →
Negative / Null Result Report

Efficacy of a Liposomal Ophthalmic Solution Containing Cross-Linked Hyaluronic Acid, Trehalose, and Stearylamine in Relieving Dry Eye-like Symptoms in Patients undergoing Multiple Intravitreal Treatments

Cagini C, Messina M, Fiore T et al. · 2026 · Preprint

Abstract Purpose This study investigates the efficacy of a liposomal ophthalmic solution containing cross-linked hyaluronic acid, trehalose, and stearylamine in reducing the occurrence of dry eye-like signs and symptoms in patients…

View details →
Negative / Null Result ReportMedicine

Effects of Dietary Conjugated Linoleic Acid on the Growth Performance of Fattening Broiler Duck and the Properties of Its Dry-Cured Products.

Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry

The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…

View details →
Negative / Null Result ReportMedicine

A Comparison of the Efficacy of Charcoal and Non-Charcoal-Bristled Electric Toothbrushes on Coffee Stain Removal and Surface Enamel Roughness: An in vitro study.

Ajai S, Agnihotri R · 2026 · Journal of dental hygiene : JDH

Purpose Recently, charcoal-based oral hygiene products, such as toothpastes, have gained popularity due to their whitening and antibacterial properties. However, there is limited data on charcoal-bristle electric toothbrushes. The purpose…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of 940 nm diode laser adjunct to mechanical debridement on S100A8 levels and clinical parameters in peri-implantitis treatment.

Nalbant A, Olgun HE, Hendek M et al. · 2026 · Lasers in medical science

The aim of this study was to compare the effectiveness of diode laser and combined treatment protocols, applied in addition to mechanical debridement, in the treatment of peri-implantitis on clinical periodontal parameters and S100A8…

View details →
Negative / Null Result ReportMedicine

Incidence and clinical impact of cystic changes in interpositional grafts following arthroscopy-assisted lower trapezius tendon transfer: A retrospective comparative clinical study.

Baek CH, Lim C, Kim JG et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Cystic changes within interpositional grafts used for arthroscopy-assisted lower trapezius tendon transfer (aLTT) are occasionally detected on postoperative magnetic resonance imaging (MRI); however, their clinical significance…

View details →
Negative / Null Result ReportOpen accessMedicine

Serum biomarkers remain stable after transitioning from intravenous to subcutaneous natalizumab in multiple sclerosis.

Muñoz-Vendrell A, Arroyo-Pereiro P, León I et al. · 2026 · Journal of neurology

Background Subcutaneous natalizumab offers greater convenience than intravenous administration, but pharmacokinetic differences have raised concerns about potential subclinical disease activity. Serum neurofilament light chain (sNfL) and…

View details →
Negative / Null Result ReportMedicine

Mandibular setback by bilateral sagittal split osteotomy: a two-year three-dimensional study of condylar positional and morphological changes.

Al-Mohana RAAM, Jianping H, Alhammadi MS et al. · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Objective To elucidate the pattern and extent of long-term condylar adaptation within the temporomandibular joint (TMJ) following mandibular setback by bilateral sagittal split osteotomy (BSSO) in patients with mandibular prognathism, with…

View details →
Negative / Null Result ReportMedicine

Assessment of eyeball findings on two sequential post-mortem computed tomography (PMCT) : no reliable marker for post-mortem interval.

Kubota H, Makino Y, Yoshida M et al. · 2026 · International journal of legal medicine

Background It is important to understand post-mortem changes in post-mortem computed tomography (PMCT) image interpretation. Only a few studies have focused on the eyeballs. This study aimed to clarify the changes in eyeball findings on…

View details →
Negative / Null Result ReportMedicine

A randomized controlled trial comparing two processes of exposure therapy: Extinction learning and habituation.

Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology

Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…

View details →
Negative / Null Result ReportMedicine

Prognostic and Predictive Factors in Metastatic Breast Cancer Patients Treated with CDK4/6 Inhibitors.

Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…

View details →
Negative / Null Result ReportMedicine

Long-term Clinical and Radiographic Outcomes After Salto Talaris Total Ankle Arthroplasty: Long-term Follow-up of a Previously Published Cohort.

Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international

Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…

View details →
Negative / Null Result ReportOpen accessMedicine

Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study.

Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal

Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…

View details →