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Browse the failure-mode index

19,859 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial.

Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science

Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…

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Negative / Null Result ReportMedicine

Diagnostic assessment of artificial intelligence reconstruction on accelerated prostate MRI: a retrospective, paired, multi-reader multi-case study.

van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology

Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…

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Negative / Null Result ReportMedicine

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels.

Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…

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Negative / Null Result ReportMedicine

Short-term outcomes of selective laser trabeculoplasty in pseudophakic primary angle-closure glaucoma after iridotomy: a retrospective pilot comparison with primary open-angle glaucoma.

Hsieh YC, Lu WY, Chen YL et al. · 2026 · BMC ophthalmology

Background Selective laser trabeculoplasty (SLT) is a widely accepted treatment for primary open-angle glaucoma (POAG), but its role in primary angle-closure glaucoma (PACG) remains less defined. This study aimed to evaluate the short-term…

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Negative / Null Result ReportMedicine

Impact of ERAS on morbidity and length of stay in elderly patients undergoing elective laparoscopic colorectal cancer surgery: a two-center comparative study.

Verbo A, Verbo I · 2026 · Langenbeck's archives of surgery

Background Enhanced Recovery After Surgery (ERAS) protocols are widely implemented in colorectal surgery to improve postoperative recovery and reduce hospital stay. However, their impact on postoperative morbidity in elderly and clinically…

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Negative / Null Result ReportMedicine

Targeting triglycerides for cardiovascular risk reduction.

Maiorca C, Tramontano D, Di Costanzo A et al. · 2026 · Internal and emergency medicine

Residual cardiovascular risk persists in many patients despite optimal control of established factors such as low-density lipoprotein cholesterol (LDL-C), blood pressure and glycaemia. Mounting evidence indicates that hypertriglyceridemia…

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Negative / Null Result ReportMedicine

Evaluation of exposure incidents in PET-CT examinations through root cause analysis.

Osorio Oliveros AV, Velasco Jaramillo JA, Alejo-Martínez H et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Purpose To implement a continuous improvement cycle aimed at identifying and reducing radiation exposure incidents in patients undergoing PET-CT scans. Methods A comparative quasi-experimental study was conducted within a nuclear medicine…

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Negative / Null Result Report

Randomized trial, parallel-group to compare effect of low-intensity transcranial magnetic stimulation (Li-TMS) on sleep disorders, inflammation levels, and brain-derived neurotrophic factor in patients with depression

Ortiz BM, Orozco SM, Dueñas LL et al. · 2026 · Preprint

Abstract Major depressive disorder (MDD) has increased in recent years, affecting 16.1% of the adult population nationwide. Currently, there are pharmacological and psychological treatments that have a 67% remission rate for depressive…

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Negative / Null Result ReportOpen accessMedicine

Comparison of antimicrobial photodynamic therapy protocols as adjunct treatment in the management of initial pericoronitis: a randomized, controlled, double-blind clinical trial.

Schalch TO, Ando-Suguimoto ES, Ferreira BS et al. · 2026 · Clinical oral investigations

Objectives The aim of this study was to compare the effectiveness of two antimicrobial photodynamic therapy (aPDT) protocols using different methylene blue formulations in the treatment of initial pericoronitis. The research question was…

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Negative / Null Result ReportMedicine

ASSOCIATION BETWEEN BASELINE GLYCATED HEMOGLOBIN LEVELS AND FUNCTIONAL AND ANATOMICAL OUTCOMES AFTER FARICIMAB LOADING PHASE IN DIABETIC MACULAR EDEMA.

Scampoli A, Governatori L, Solimeo A et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To evaluate whether baseline glycosylated hemoglobin (HbA1C) levels play a predictive role in faricimab loading phase outcomes. In addition, the authors assessed the efficacy of faricimab loading phase for diabetic macular edema…

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Negative / Null Result ReportMedicine

Analgesic efficacy of equal-dose bupivacaine diluted to 20 vs. 30 mL for anterior quadratus lumborum block after cesarean delivery: a randomized double-blind trial.

Pajina B, Leurcharusmee P · 2026 · Minerva anestesiologica

Background The anterior quadratus lumborum (QL) block provides effective post-cesarean delivery analgesia, but the optimal local anesthetic (LA) volume remains unknown. This is critical for balancing efficacy and safety in pregnant…

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