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19,854 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

[Analysis of the reimbursement times of antitumor drugs in Italy in relation to the clinical benefit expressed by the European Society for Medical Oncology (ESMO-MCBS)].

Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina

Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…

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Negative / Null Result ReportOpen accessMedicine

Propensity score-matched evaluation of prophylactic hyperthermic intraperitoneal chemotherapy in geriatric patients with locally advanced colorectal cancer: safety and survival benefits.

Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer

AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…

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Negative / Null Result ReportMedicine

Computer-aided polyp detection multicenter international randomized controlled study with a focus on community clinics: Geriatric Assessment-Driven Intervention clinical trial.

Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy

Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…

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Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitor Therapy for Advanced, Unresectable Esophageal Squamous Cell Carcinoma: A Series of Patient-level Meta-analyses From Phase III Trials.

Beshr MS, Shembesh RH, Nounou MV et al. · 2026 · Clinical oncology (Royal College of Radiologists (Great Britain))

Aim This study reconstructed patient-level data to provide updated evidence on survival outcomes across PD-L1 expression subgroups. Materials and methods A systematic search was conducted on March 2, 2025, using PubMed, Embase, Web of…

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Negative / Null Result ReportMedicine

Effect of vaginal estrogen supplementation for luteal phase support in the GnRH antagonist protocol on pregnancy outcomes for IVF/ICSI cycles: a randomized controlled trial.

Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open

Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…

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Negative / Null Result ReportMedicine

Energy restriction and iron supplementation improve iron status in women with obesity regardless of red meat consumption: a randomized controlled trial.

Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports

Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…

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Negative / Null Result ReportMedicine

Leptomeningeal carcinomatosis in gastric cancer: a single-center retrospective analysis of 86 cases.

Byun SH, Kim TS, Ahn S et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Background Leptomeningeal carcinomatosis (LMC) is a rare but highly lethal manifestation of gastric cancer. We sought to describe its clinical features and define prognostic factors in a large single-center cohort. Methods We…

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Negative / Null Result ReportMedicine

Evaluation of betaxolol in improving the glasgow outcome scale extended (GOSE) of the acute phase of patients with mild to moderate Traumatic Brain Injury: a double blinded randomized clinical trial.

Zeynodini Meimand H, Anbarloui MR, Eslamian M et al. · 2025 · Neurological research

Background Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality. It is important to have an effective treatment that can improve the quality of life and cognitive functions of these patients.…

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Negative / Null Result ReportMedicine

Dose-Response Relationships of Tea, Coffee, and Alcohol Consumption With Cognitive Function in Middle-Aged and Older Adults: Analysis Based on the China Health and Nutrition Survey (CHNS).

Zeng Z, Ye X, He H et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

This study examined the associations of tea, coffee, and alcohol consumption with cognitive function in Chinese adults aged ≥45 years ( n = 1326), using data from the China Health and Nutrition Survey (1997-2006). Multiple linear…

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Negative / Null Result Report

Adjuvant transarterial chemoembolization for solitary large hepatocellular carcinoma by microvascular invasion and/or satellite lesion burden：A Multi-Center Retrospective Study

Chen C, Tao Q, Lu C et al. · 2025 · Preprint

Abstract Background: Adjuvant therapy for solitary large hepatocellular carcinoma (SLHCC) remained unclear. Methods: 1292 SLHCC patients treated with hepatectomy between January 2010 and December 2020 were included in this retrospective…

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Negative / Null Result ReportMedicine

Prospective evaluation of nonporous wrap fails to minimize inadvertent perianesthetic hypothermia in healthy canine patients undergoing ovariohysterectomy.

Bartels CM, Ranganathan B, Spinner M · 2025 · Journal of the American Veterinary Medical Association

Objective To prospectively evaluate a nonporous wrap's ability to prevent inadvertent perianesthetic hypothermia (IPH) in canines undergoing ovariohysterectomy. Methods All client-owned canines and felines undergoing ovariohysterectomy…

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Negative / Null Result ReportMedicine

Growth Hormone's Impact on Oxidative Stress, Ovarian Response, and <i>In Vitro</i> Fertilization in Polycystic Ovary Syndrome Across Different Ages.

Zhao P, Wang X, Zhang Q et al. · 2025 · British journal of hospital medicine (London, England : 2005)

Aims/Background Growth hormone (GH) supplementation contributes to improved reproductive and pregnancy outcomes in in vitro fertilization (IVF)-embryo transfer (ET) in polycystic ovary syndrome (PCOS) women. This study aimed to explore the…

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Negative / Null Result ReportOpen accessMedicine

Preoperative 15 mg of melatonin for reducing anxiety and post-traumatic stress disorder symptoms in mandibular third molar surgery: A randomized double-blind placebo-controlled clinical trial.

Rosa HH, Ruppel C, Trappel ND et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background This study evaluated the efficacy of a single 15 mg preoperative sublingual dose of melatonin in reducing anxiety as the primary outcome, and its effects on psychomotor performance, postoperative sleep quality, and early…

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Negative / Null Result ReportMedicine

Quality of life effects of renal artery stenting versus medical therapy for atherosclerotic renal-artery stenosis: results from the randomized CORAL trial.

Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes

Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…

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Negative / Null Result ReportMedicine

Comprehensive Analysis of a Single-Center Inpatient Posttransplant Physical Therapy Program in High-Acuity Patients: Is It Worth the Effort?

Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons

Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…

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Negative / Null Result ReportOpen accessMedicine

The combination of atezolizumab and BCG in high-risk non-muscle invasive bladder cancer: results of the phase Ib/II BladderGATE clinical trial.

Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist

Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…

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