19,743 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Roger E. Beaty, Emily C. Nusbaum, Paul J. Silvia · 2014 · Psychology of Aesthetics Creativity and the Arts
Insight problems are commonly used to assess creative problem solving. Such problems are often employed by proponents of the associative view of creativity—the notion that creative ideas result from unconscious processes. Surprisingly…
View details →J. Howard Choat, O. Selma Klanten, Lynne van Herwerden et al. · 2012 · Biological Journal of the Linnean Society
Phylogenetic reconstruction of the evolutionary relationships among 61 of the 70 species of the parrotfish genera Chlorurus and Scarus (Family Labridae) based on mitochondrial and nuclear gene sequences retrieved 15 well-supported clades…
View details →June-Hyuk Kwon, Seung-Hye Jung, Hyun-ju Choi et al. · 2020 · Journal of Product & Brand Management
Purpose This study aims to empirically analyze the effects of marketing communications, such as advertisement/promotion and social network service (SNS) content, on consumer engagement (CE), brand trust and brand loyalty.…
View details →Dehui Xu, Baofeng Huo, Linyan Sun · 2014 · Industrial Management & Data Systems
Purpose – The purpose of this paper is to explore the effects of intra-organizational resources, including top management support (TMS) and information technology (IT), on inter-organizational capabilities including supply chain…
View details →Abayineh Amare, Belay Simane · 2017 · Agriculture & Food Security
Smallholder farmers’ decisions to adopt adaptation options in response to climate change and variability are influenced by socioeconomic, institutional, and environmental factors, indicating that decision patterns can be very specific to a given locality. The prime objective of this research is to identify factors affecting smallholder farmers’ decisions to adopt adaptation options to climate change and variability in the Muger River sub-basin of the Blue Nile basin of Ethiopia. Both quantitative and qualitative data were collected using a semi-structured questionnaire, focused group discussio
View details →Erfan Sayyari, Siavash Mirarab · 2018 · Genes
Phylogenetic species trees typically represent the speciation history as a bifurcating tree. Speciation events that simultaneously create more than two descendants, thereby creating polytomies in the phylogeny, are possible. Moreover, the inability to resolve relationships is often shown as a (soft) polytomy. Both types of polytomies have been traditionally studied in the context of gene tree reconstruction from sequence data. However, polytomies in the species tree cannot be detected or ruled out without considering gene tree discordance. In this paper, we describe a statistical test based on
View details →Samuel J. Gershman, Edward Vul, Joshua B. Tenenbaum · 2011 · Neural Computation
Ambiguous images present a challenge to the visual system: How can uncertainty about the causes of visual inputs be represented when there are multiple equally plausible causes? A Bayesian ideal observer should represent uncertainty in the…
View details →Julie M. Cridland, Stuart J. Macdonald, Anthony D. Long et al. · 2013 · Molecular Biology and Evolution
Here we present computational machinery to efficiently and accurately identify transposable element (TE) insertions in 146 next-generation sequenced inbred strains of Drosophila melanogaster. The panel of lines we use in our study is…
View details →Allison Bond, Heather Mason, Chelsey Lemaster et al. · 2013 · Medical Education Online
OBJECTIVE: An effective career in medicine requires empathy and compassion, yet the demands of a medical education increase stress and decrease students' ability to connect with patients. However, research suggests mind-body practices improve psychological well-being. This study aimed to evaluate the psychological effects on medical students of an 11-week elective course, Embodied Health or EH, which combines yoga and meditation with neuroscience didactics. METHODS: The effects on 27 first- and second-year medical students were evaluated via surveys in four areas: empathy, perceived stress, se
View details →Scott N. Dean, Barney Bishop, Monique L. van Hoek · 2011 · Frontiers in Microbiology
Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection. Interest in anti-microbial peptides (AMPs) has grown due to their potential therapeutic applications and their possible use against antibiotic resistant bacteria. LL-37 is the only cathelicidin expressed by humans. In this study, we tested LL-37 and the effect of a protease-resistant LL-37 peptide mimetic, the peptide enantiomer D-LL-37, for anti-microbial and anti-biofilm activity against P. aeruginosa. Both forms
View details →Rachel Saunders‐Pullman, Anat Mirelman, Roy N. Alcalay et al. · 2018 · JAMA Neurology
Importance: Few prospective longitudinal studies have evaluated the progression of Parkinson disease (PD) in patients with the leucine-rich repeat kinase 2 (LRRK2 [OMIM 609007]) mutation. Knowledge about such progression will aid clinical…
View details →Valeria Fochi, Walter Chitarra, Annegret Kohler et al. · 2016 · New Phytologist
Orchids are highly dependent on their mycorrhizal fungal partners for nutrient supply, especially during early developmental stages. In addition to organic carbon, nitrogen (N) is probably a major nutrient transferred to the plant because…
View details →Hawazin Faruki, Gregory M. Mayhew, Jonathan S. Serody et al. · 2017 · Journal of Thoracic Oncology
INTRODUCTION: Molecular subtyping of lung adenocarcinoma (AD) and lung squamous cell carcinoma (SCC) reveal biologically diverse tumors that vary in their genomic and clinical attributes. METHODS: Published immune cell signatures and…
View details →Takuya Kuroda, Satoshi Yasuda, Shinji Kusakawa et al. · 2012 · PLoS ONE
Human induced pluripotent stem cells (hiPSCs) possess the capabilities of self-renewal and differentiation into multiple cell types, and they are free of the ethical problems associated with human embryonic stem cells (hESCs). These characteristics make hiPSCs a promising choice for future regenerative medicine research. There are significant obstacles, however, preventing the clinical use of hiPSCs. One of the most obvious safety issues is the presence of residual undifferentiated cells that have tumorigenic potential. To locate residual undifferentiated cells, in vivo teratoma formation assa
View details →Christian Dustmann, Patrick A. Puhani, Uta Schönberg · 2016 · The Economic Journal
We investigate the effects of attending a more advanced track in middle school on long‐term education and labour market outcomes for Germany, a country with a rigorous early‐age tracking system, where the risk of misallocating students is…
View details →Guillermo Campitelli, Fernand Gobet · 2011 · Current Directions in Psychological Science
Deliberate practice (DP) occurs when an individual intentionally repeats an activity in order to improve performance. The claim of the DP framework is that such behavior is necessary to achieve high levels of expert performance. The…
View details →Damon Clark, Paco Martorell · 2014 · Journal of Political Economy
This paper distinguishes between the human capital and signaling theories by estimating the earnings return to a high school diploma. Unlike most indicators of education (e.g., a year of school), a diploma is essentially a piece of paper…
View details →Gerrit Fischer, Axel Stadie, Róbert Reisch et al. · 2011 · Operative Neurosurgery
BACKGROUND: Improvements in preoperative imaging and intraoperative visualization have led to a refinement in surgical techniques. OBJECTIVE: Report of a 20-year experience with application of the keyhole technique as a contribution to the…
View details →Jan Budczies, Carsten Denkert, Berit Müller et al. · 2012 · BMC Genomics
BACKGROUND: Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far. RESULTS: A cohort of 271 breast cancer and 98 normal tissue samples was investigated using GC-TOFMS-based metabolomics. A total number of 468
View details →Sunbok Lee, Jae Young Chung · 2019 · Applied Sciences
A dropout early warning system enables schools to preemptively identify students who are at risk of dropping out of school, to promptly react to them, and eventually to help potential dropout students to continue their learning for a better future. However, the inherent class imbalance between dropout and non-dropout students could pose difficulty in building accurate predictive modeling for a dropout early warning system. The present study aimed to improve the performance of a dropout early warning system: (a) by addressing the class imbalance issue using the synthetic minority oversampling t
View details →Alex Grier, Xing Qiu, Sanjukta Bandyopadhyay et al. · 2017 · Microbiome
BACKGROUND: Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants. RESULTS: With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and growth: a categorical model with three successive microbiota phases (P1, P2, and P3) and a model with two periods (ea
View details →Jenna R. Krall, James A. Mulholland, Armistead G. Russell et al. · 2016 · Environmental Health Perspectives
BACKGROUND: Short-term exposure to ambient fine particulate matter (PM2.5) concentrations has been associated with increased mortality and morbidity. Determining which sources of PM2.5 are most toxic can help guide targeted reduction of PM2.5. However, conducting multicity epidemiologic studies of sources is difficult because source-specific PM2.5 is not directly measured, and source chemical compositions can vary between cities. OBJECTIVES: We determined how the chemical composition of primary ambient PM2.5 sources varies across cities. We estimated associations between source-specific PM2.5
View details →Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman et al. · 2016 · Critical Care
BACKGROUND: During resuscitation in severe sepsis and septic shock, several goals are set. However, usually not all goals are equally met. The aim of this study is to determine the relative importance of the different goals, such as mean arterial pressure (MAP), lactate, central venous oxygen saturation (ScvO2) and central to forefoot temperature (delta-T), and how they relate to intensive care unit (ICU) and hospital mortality. METHODS: In a retrospective cohort study in a 20-bed mixed medical and surgical ICU of a teaching hospital we studied consecutive critically ill patients who were admi
View details →Anthony Montgomery, Florina Spânu, Adriana Băban et al. · 2015 · Burnout Research
According to the Job Demands-Resources (JD-R) model, burnout and engagement are psychological reactions that develop when individual characteristics interact with work characteristics. This study tests the JD-R model using multilevel…
View details →Masayuki Hirukawa, Masako Ueda · 2011 · Pacific Economic Review
Abstract Policy‐makers typically interpret positive relations between venture capital (VC) investments and innovations as evidence that VC investments stimulate innovation ( VC‐first hypothesis ). This interpretation is, however, one‐sided…
View details →Dongshan Yang, Chuan-En Wang, Bentian Zhao et al. · 2010 · Human Molecular Genetics
Neurodegeneration is a hallmark of many neurological diseases, including Alzheimer's, Parkinson's and the polyglutamine diseases, which are all caused by misfolded proteins that accumulate in neuronal cells of the brain. Although apoptosis…
View details →Moira Strand Hutchinson, Guri Grimnes, Ragnar M. Joakimsen et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: Ecologic and observational studies have suggested an association between serum 25-hydroxyvitamin D (25(OH)D) levels and cardiovascular disease (CVD) risk factors, CVD mortality, and cancer mortality. Based on this, low serum…
View details →Ahmad Juwaini, Gusli Chidir, Dewiana Novitasari et al. · 2022 · International Journal of Data and Network Science
This study aims to determine the effect of e-service quality on customer e-satisfaction, the effect of e-trust on customer e-satisfaction, the effect of e-service quality on customer e-loyalty, the effect of e-trust on customer e-loyalty and finally, the effect of e-satisfaction on online shop customer e-loyalty. The type of research used in this research is correlational research with a quantitative approach and testing the research hypothesis was carried out by using the Structural Equation Model (SEM) approach based on Partial Least Square (PLS). The sample or respondent used in this study
View details →Christopher Summerfield, Valentin Wyart, Vanessa M. Johnen et al. · 2011 · Frontiers in Human Neuroscience
Repetitions of a sensory event elicit lower levels of brain activity than its initial presentation ("repetition suppression," RS). According to one view, RS depends on the biophysics of neuronal discharge, and is thus an automatic consequence of stimulus processing ("fatigue" model). Another account suggests that RS depends on the statistical structure of the environment, and occurs when repeated stimuli are less surprising than novel stimuli ("surprise reduction" model). In support of the latter view, functional magnetic resonance imaging studies have shown that RS is modulated by the local p
View details →Jonathan E. Sutton, Dionisios G. Vlachos · 2012 · ACS Catalysis
We present a theoretical and computational analysis to elucidate the relation of the Brønsted–Evans–Polanyi (BEP) and transition state scaling (TSS) correlations. We find that the TSS correlation is an approximation of the BEP correlation.…
View details →