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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Early and later susceptibility to effects of parenting: Exploring Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis.

Zhang X, Machlin L, McLaughlin K et al. · 2025 · Developmental psychology

This study tests Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis by examining individual differences in susceptibility to the effects of parenting during early and late childhood. Drawing from the Future of…

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Negative / Null Result ReportOpen accessMedicine

Mirror exposure in adolescents with anorexia nervosa: a feasibility study on body image disturbance and attentional bias.

Pelzer M, Werthmann J, Svaldi J et al. · 2026 · Eating and weight disorders : EWD

Purpose Body image disturbances (BID) are central to anorexia nervosa (AN), influencing its development, maintenance and relapse. While mirror exposure (ME) has been shown to reduce BID in adults, research in adolescents is limited. This…

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Negative / Null Result ReportOpen accessMedicine

A randomized digital behavioral intervention for prenatal and postpartum weight outcomes in women with overweight or obesity: the GROWell trial.

Simmons LA, Phipps JE, Castro-Alvarez S et al. · 2026 · BMC pregnancy and childbirth

Background Rising rates of overweight and obesity globally have led to an increasing number of women who enter pregnancy with excess weight, posing significant health risks to mothers and infants. Mobile health interventions, such as…

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Negative / Null Result ReportMedicine

Effect of genistein and coenzyme Q10 in oxidative damage and mitochondrial membrane potential in an attenuated type II mucopolysaccharidosis cellular model.

Delgado CA, Poletto E, Vera LNP et al. · 2024 · Cell biochemistry and function

Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for iduronate-2-sulfatase (IDS), which leads to a great clinical heterogeneity presented by these…

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Negative / Null Result ReportOpen accessMedicine

Plasma von Willebrand Factor and ADAMTS13 Interact With <i>APOE</i>-ε4 in Predicting Longitudinal Brain Atrophy and Cognitive Decline Over a 9-Year Follow-Up.

Adegboye HA, Sun Y, Zhang P et al. · 2026 · Journal of the American Heart Association

Background Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests apolipoprotein E ( APOE )-ε4 alters VWF release. This…

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Negative / Null Result ReportMedicine

Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.

Luchetti M, Terracciano A, Karakose S et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objective This study examines how multiple dimensions of socio-emotional well-being relate to cognitive functioning in older adults, and whether the associations vary by cognitive status, depression, and socio-demographic factors. Methods…

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Negative / Null Result ReportOpen accessMedicine

No immediate attentional bias towards or choice bias for male secondary sexual characteristics in Bornean orang-utans (Pongo pygmaeus).

Roth TS, Samara I, Perea-Garcia JO et al. · 2024 · Scientific reports

Primate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or…

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Negative / Null Result ReportOpen accessMedicine

Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.

Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging

Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…

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Negative / Null Result ReportOpen accessMedicine

Stride Velocity 95th Centile Detects Decline in Ambulatory Function Over Shorter Intervals than the 6-Minute Walk Test or North Star Ambulatory Assessment in Duchenne Muscular Dystrophy.

Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases

Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…

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Negative / Null Result ReportOpen accessMedicine

Patient-reported outcomes of a randomized phase III clinical trial of adjuvant radiation versus chemoradiation in intermediate risk, stage I/IIA cervical cancer patients treated with initial radical hysterectomy and pelvic lymphadenectomy (NRG/GOG-0263).

Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology

Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…

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Negative / Null Result ReportOpen accessMedicine

The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.

Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology

Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…

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Negative / Null Result ReportOpen accessMedicine

Long-term effects of cooking with liquefied petroleum gas or biomass on linear growth trajectories from birth to the pre-school years in Puno, Peru: a prospective cohort study.

Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas

Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…

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Negative / Null Result ReportOpen accessMedicine

Air Pollution and Blood Pressure: Evidence From Indonesia.

Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth

Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…

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Negative / Null Result ReportOpen accessMedicine

Women With Ovulatory Cycles Have Longer Sleep, but Phases of Their Menstrual Cycles Do Not Differ in Sleep Characteristics.

Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…

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Negative / Null Result ReportOpen accessMedicine

The role of household composition in social isolation and anxiety: evidence from adults in South Africa during the COVID-19 pandemic.

Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…

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