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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

First head-to-head comparison of allograft repair, direct neurorrhaphy and non-surgical management for iatrogenic trigeminal nerve injury: a prospective multicentre cohort study with doubly robust analysis.

Van der Cruyssen F, Willaert R, Palla B et al. · 2026 · International journal of oral and maxillofacial surgery

Trigeminal nerve injuries severely degrade quality of life, yet comparative effectiveness evidence for existing treatments is scarce. The authors prospectively followed 153 adults with iatrogenic lingual or inferior alveolar nerve injuries…

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Negative / Null Result ReportMedicine

Changes in Gait Kinematics with Continuous Intrathecal Baclofen Infusion for Spasticity After Acquired Brain Injury: A Comparison of Implanted and Non-Implanted Cohorts.

Chow JW, Yablon SA, Stokic DS · 2026 · NeuroRehabilitation

BackgroundAlthough several studies have examined gait changes associated with continuous intrathecal baclofen (CITB) infusion for spasticity in ambulatory patients with acquired brain injury (ABI), none has included a control…

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Negative / Null Result ReportOpen accessMedicine

Mid-term outcomes and hemodynamic performance of Edwards 19-mm-labeled aortic valve bioprostheses: a single-center retrospective study.

Gyoten T, Akatsu T, Kuroda T et al. · 2026 · Journal of cardiothoracic surgery

Background This study aimed to evaluate clinical outcomes after surgical aortic valve replacement with third-generation Edwards (Edwards Lifesciences, Irvine, CA, USA) 19-mm-labeled aortic valve bioprostheses, including a rapid-deployment…

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Negative / Null Result Report

Impact of Preoperative Teriparatide Use on Proximal Junctional Kyphosis Prevention in Osteopenic/Osteoporotic Patients Undergoing Adult Spinal Deformity Surgery: A Propensity Score-Matched Study

Oh J, Park J, Kang D et al. · 2026 · Preprint

Background: /Objectives: Poor bone quality significantly increases the risk of mechanical complications after adult spinal deformity (ASD) surgery, including proximal junctional kyphosis (PJK) and proximal junctional failure (PJF).…

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Negative / Null Result ReportMedicine

Inflammatory biomarkers and sarcopenia in older adults.

Kanakan A, Singh A, Kumari S et al. · 2026 · Frontiers in aging

Chronic inflammation contributes to the pathogenesis of sarcopenia in older adults. This study aimed to evaluate the correlation between inflammatory biomarkers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α),…

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Negative / Null Result ReportMedicine

Potential contribution of extended reality to safety in minimally invasive hepatectomy: a comparative study of laparoscopic and robotic approaches.

Naito S, Kajiwara M, Nakashima R et al. · 2026 · Journal of robotic surgery

Minimally invasive liver surgery requires a precise understanding of complex liver anatomy. Extended reality (XR) technologies, including virtual reality and mixed reality, offer promising solutions for enhancing preoperative planning and…

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Negative / Null Result ReportMedicine

Radiographic correction of medial-column malalignment after minimally invasive versus open talonavicular arthrodesis: A single-centre comparative cohort study.

Werneburg F, Beschauner J, Felsberg M et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Background Talonavicular (TN) arthrodesis can be performed open or minimally invasively (MIS); whether MIS reproduces the radiographic medial-column re-alignment of open surgery remains unclear. Methods Retrospective cohort of 56 feet (32…

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Negative / Null Result ReportMedicine

Respiratory syncytial virus incidence and clinical outcomes in patients with inflammatory bowel disease: a National Veterans Affairs cohort study.

Khan N, Sundararajan R, Caldera F et al. · 2026 · Inflammatory bowel diseases

Background Data describing the incidence and clinical outcomes of respiratory syncytial virus (RSV) infection among patients with inflammatory bowel disease (IBD) are limited. Methods We conducted a nationwide retrospective cohort study…

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Negative / Null Result ReportMedicine

Evaluating the Quality of Artificial Intelligence-Generated Rubrics and Grading Reliability in Student-Written Reflection Assignments.

Dicken S, DeLeon N, Gutierrez EJ et al. · 2026 · American journal of pharmaceutical education

Objective To investigate whether generative artificial intelligence (genAI) can improve pharmacy assessment practices, specifically, rubric development, and the grading of student-written reflection assignments. Methods Sample…

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Negative / Null Result ReportMedicine

Purine Metabolism Alterations in Patients with Chronic Heart Failure: A Cross-Sectional Study of Associations with Iron Status, Oxidative Stress, and Anemia.

Konysbek Y, Turar A, Molotov-Luchanskiy VB et al. · 2026 · Metabolites

Background/Objectives : Anemia and iron dysregulation are common in chronic heart failure (CHF), but additional metabolic mechanisms may contribute to these alterations. This study aimed to evaluate purine metabolism and oxidative stress…

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Negative / Null Result ReportMedicine

Long-Term Outcomes After Percutaneous Coronary Intervention With the Polymer-Free Biolimus-Coated BioFreedom Stent Versus the Biodegradable-Polymer Sirolimus-Eluting Orsiro Stent in Patients With Acute Coronary Syndromes.

Noori M, Christiansen EH, Hougaard M et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The polymer-free biolimus A9-coated BioFreedom stent (BF-BCS) releases a lipophilic drug that may provide a potent anti-inflammatory effect in patients with acute coronary syndromes (ACS). Five-year efficacy and safety of BF-BCS…

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Negative / Null Result ReportMedicine

Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism.

Krol MA, Skodova T, Jellema T · 2026 · Autism research : official journal of the International Society for Autism Research

We investigated possible atypicalities in activation of cortical motor-related circuits in young adults with Autism Spectrum Conditions (ASC) and typical-development (TD) when observing others' actions. Activation of these circuits is…

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Negative / Null Result ReportMedicine

Indoor discomfort from ground transportation traffic vibration and noise-Comparison between Vietnamese and Japanese young participants.

Tung NT, Matsumoto Y, Yokoshima S et al. · 2026 · The Journal of the Acoustical Society of America

This research investigated discomfort responses to combined whole-body vibration and noise in Vietnamese and Japanese participants. Twenty stimuli, comprising five vibration magnitudes and six noise levels induced by ground transportation…

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