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Browse the failure-mode index

19,854 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Neoadjuvant Chemotherapy for Oropharyngeal Cancer Treatment De-Escalation: From Historical Failures to Contemporary HPV-Driven Paradigms.

Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers

Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…

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Negative / Null Result ReportMedicine

Apolipoprotein L1 Genetic Testing and Counseling Does Not Reduce Living Kidney Donors' Willingness to Donate : A Hybrid Type 2 Nonrandomized Controlled Trial.

Gordon EJ, Gacki-Smith J, Smith JD et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN

Key points Apolipoprotein L1 genetic testing did not reduce potential living donors' willingness to donate, supporting integration of testing into practice. The Apolipoprotein L1 Testing and Counseling Program did not reduce potential…

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Negative / Null Result ReportMedicine

Serial assessment of NT-proBNP and high-sensitivity cardiac troponin with glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes: Insights from EXSCEL.

Kittipibul V, Nguyen M, Welsh P et al. · 2026 · American heart journal

Background In the EXSCEL trial, exenatide did not reduce major adverse cardiovascular events (MACE), but heterogeneity of benefit and the role of cardiac biomarkers remain uncertain. We evaluated the prognostic value of baseline and 1-year…

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Negative / Null Result ReportMedicine

Plasma exchange for severe alveolar hemorrhage in antineutrophil cytoplasmic antibody-associated vasculitis: emulation of a target trial.

Sanna AC, Gendreau S, Desnos C et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Patients with severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-related diffuse alveolar hemorrhage (DAH) face high mortality. In the PEXIVAS trial, plasma exchange (PLEX) did not reduce death or…

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Negative / Null Result ReportOpen accessMedicine

Association between NT-proBNP and ivabradine in patients after noncardiac surgery: a per-protocol analysis of the PREVENT-MINS study.

Gorka J, Putowski Z, Wludarczyk A et al. · 2025 · Anaesthesiology intensive therapy

Background The PREVENT-MINS trial investigated whether perioperative heart rate reduction with ivabradine could prevent myocardial injury after noncardiac surgery (MINS). Although ivabradine modestly reduced heart rate, it did not reduce…

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Negative / Null Result ReportMedicine

Pearls & Oy-Sters: Plantar Agraphesthesia in Corticobasal Syndrome.

Perkins JA, Price RS, Vizcarra JA · 2026 · Neurology

We describe a 70-year-old man with no significant medical history who developed progressive left leg numbness, gait dysfunction, and recurrent falls. Within a year, he reported difficulty with both initiating steps and perceiving his left…

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Negative / Null Result ReportMedicine

[A Case of Robot-Assisted Thoracoscopic Extended Thymectomy for Thymoma Associated with Generalized Myasthenia Gravis].

Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy

A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…

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Negative / Null Result ReportMedicine

Reperfusion grade and clinical outcome following medium vessel occlusion thrombectomy in the Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions (ESCAPE-MeVO) trial.

Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery

Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…

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Negative / Null Result ReportMedicine

Balancing risks in febrile hip fracture patients: is surgical delay more dangerous than infection?

Balziano S, Margalit I, Kollender R et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible…

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Negative / Null Result ReportMedicine

Romosozumab does not improve volumetric bone mineral density at distal radius but is associated with early changes in bone strength: a prospective study.

Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…

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Negative / Null Result ReportOpen accessMedicine

Clonal hematopoiesis in lung adenocarcinoma pathogenesis.

Parisi T, Santibanez Ocampo B, Adelman J et al. · 2026 · JCI insight

Age-related blood cell mutations (clonal hematopoiesis) reshape immune cells and lung tumor immune structures, but did not increase lung cancer growth in a genetically engineered mouse model. .

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Negative / Null Result ReportOpen accessMedicine

Effects of Dietary Deoxynivalenol on Growth Performance, Immunity, Reproductive Hormones, and Microbiome-Metabolome Responses in Immature Gilts.

Li Z, Hu X, Feng H et al. · 2026 · Animals : an open access journal from MDPI

We evaluated the effects of different levels of DON (LD 441 and HD 1223 μg DON/kg in diet) on the growth performance, immunity, reproductive hormones, and intestinal health of immature gilts. No significant differences were observed in…

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Negative / Null Result ReportMedicine

Sympathetic transduction to blood pressure following three days in hypobaric hypoxia: Influence of nocturnal periodic breathing.

Fisher JP, Roche J, Duffy AG et al. · 2026 · Autonomic neuroscience : basic & clinical

We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not…

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Negative / Null Result ReportMedicine

Comparing the effects of commercial to open initial specimen diversion techniques on clinical outcomes and institutional costs.

Yang EH, Lopez C, Shay SL et al. · 2026 · Infection control and hospital epidemiology

The clinical outcomes associated with using commercial versus open ISDTs (initial specimen diverting techniques) remain unclear. This multicenter study showed that switching from the commercial to open ISDT did not change blood culture…

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Negative / Null Result ReportMedicine

Lights, Cameras, Action - The influence of lighting and camera position on walking and running kinematic measurements using Theia3D markerless motion capture.

Thomas A, Tucker CB, Lunn DE et al. · 2026 · Journal of biomechanics

Studies investigating the concurrent validity of markerless motion capture (MMC) systems for obtaining joint and segment kinematics have largely failed to consider the impact of ambient lighting and camera position, which can both affect…

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Negative / Null Result ReportMedicine

Salt exposure disrupts memory retrieval in habituation and conditioned place preference in planaria (Dugesia japonica).

Tazumi T, Prados J, Urcelay GP · 2026 · Journal of comparative psychology (Washington, D.C. : 1983)

This study examined whether saline acts as an aversive stimulus for planarians and how it influences learning and memory. Using saline as an unconditioned stimulus, we first tested conditioned place avoidance. Saline did not support…

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Negative / Null Result ReportMedicine

Long-term effects of almond consumption on cognitive performance and brain vascular function: a randomized crossover trial in overweight/obese adults with prediabetes.

Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition

Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…

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Negative / Null Result ReportMedicine

Continuous Monitoring by a Wearable Sensor Did Not Enhance Discharge Decision-Making in an Acute Admission Ward: Results of a Randomized Controlled Trial.

Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics

Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…

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