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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

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Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

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Negative / Null Result ReportMedicine

Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia.

Gándara-Mireles JA, Reyes Espinoza EA, Loera-Castañeda V et al. · 2026 · Current issues in molecular biology

Doxorubicin (Dox) is a cornerstone in the treatment of pediatric acute lymphoblastic leukemia (ALL), but its use is limited by dose-dependent cardiotoxicity. Oxidative stress, arising from mitochondrial dysfunction, enzymatic generation of…

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Negative / Null Result Report

Impact of sleep disorders and cardiovascular disease comorbidity on memory function decline in middle-aged and older adults: a 10-year trajectory analysis based on CHARLS

Peng M, Yuan Z, Lu Y et al. · 2026 · Preprint

Abstract Objective This study aims to investigate the effects of sleep disorders and cardiovascular disease comorbidity on the decade-long trajectory of memory function in middle-aged and elderly populations, thereby offering a scientific…

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Negative / Null Result ReportMedicine

Predictive value of peak left atrial reservoir strain combined with left atrial appendage flow velocity for atrial fibrillation recurrence after pulsed field ablation.

Wang S, Miao J, Tang F et al. · 2026 · BMC cardiovascular disorders

Background The recurrence rate after ablation for atrial fibrillation (AF) remains high, and the predictive performance of existing predictors is limited. Left atrial dysfunction plays a key role in the occurrence and progression of AF.…

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Negative / Null Result ReportOpen accessMedicine

Association Between Individual Functional Movement Screen™ Tasks and Sports Injury Occurrence in University Basketball Players: A Prospective Cohort Study.

Kikumoto T, Kobayashi M, Hori S et al. · 2026 · International journal of sports physical therapy

The Functional Movement Screen™ (FMS™) is widely used to evaluate movement quality and attempt to identify athletes at risk of injury. However, the predictive value of the total score is inconsistent, and it remains unclear whether…

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Negative / Null Result ReportMedicine

Multidimensional Physiologic Adaptations to a 14-Day Detraining Period in Elite Powerlifters: Neuromuscular, Morphological, and Hormonal Responses.

Yılmaz U, Buzdağlı Y, Bilgin S et al. · 2026 · Journal of strength and conditioning research

Abstract Yılmaz, U, Buzdağlı, Y, Bilgin, S, Sepil, Y, Ozan, M, Bağaçlı, UH, Şıktar, E, Baygutalp, F, and Kılıç Baygutalp, N. Multidimensional physiologic adaptations to a 14-day detraining period in elite powerlifters: Neuromuscular,…

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Negative / Null Result ReportOpen accessMedicine

Accessory renal arteries in prenatal hydronephrosis as a pathophysiologic contributor or incidental vascular finding: a prospective observational study.

Avcı EA, Bülbül GA, Tsakır B et al. · 2026 · BMC pregnancy and childbirth

Background Accessory renal arteries (ARAs) are recognized as an extrinsic cause of hydronephrosis in children; however, their relationship with prenatally detected hydronephrosis remains unclear. This prospective study aimed to evaluate…

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Negative / Null Result ReportMedicine

Preoperative CT-Based Pelvic Sarcopenia and Subcutaneous Adiposity Are Associated with Anaemia and Operative Time in Acetabular Fracture Surgery: A Retrospective Cohort Study.

Okur KT, Abdulaliyev F, Yalçın S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Acetabular fracture surgery is associated with substantial perioperative blood loss and prolonged operative time. Routine preoperative pelvic computed tomography (CT) carries information about body composition…

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Negative / Null Result ReportMedicine

Addition of antibiotic-impregnated bone cement discs for reduction of periprosthetic infection in implant-based breast reconstruction.

Connor CH, Katsnelson JY, Paul BJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Periprosthetic infection is a frequent complication of implant-based breast reconstruction, often resulting in implant removal, additional surgery, and increased costs. This study evaluated whether polymethyl methacrylate (PMMA) discs…

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Negative / Null Result ReportMedicine

Hook plate versus locking plate fixation in lateral clavicle fractures: operative efficiency and cumulative surgical burden in a propensity score-matched cohort study.

Schibler D, Hinkelmann MA, Frei F et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

INTRODUCTION: Hook plates remain controversial in the management of lateral clavicle fractures despite their biomechanical advantages. Concerns include implant-related complications, subacromial irritation, and the need for routine implant…

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Negative / Null Result ReportMedicine

Clinical Effects of Angulated Single-Implant Crowns With Different Retention Methods in the Aesthetic Area: A Retrospective Cohort Study With 12-24 Months Follow-Up.

Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research

Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…

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Negative / Null Result ReportMedicine

One-stage hepatectomy may be a safe and feasible alternative to ALPPS for hepatocellular carcinoma with liver fibrosis or cirrhosis and FLR/SLV ratio of 30% - 40% - A multicenter study.

Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…

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Negative / Null Result ReportOpen accessMedicine

Prognostic Utility of Albumin and the C-Reactive Protein-to-Albumin Ratio for Predicting Intravenous Steroid Response in Acute Severe Ulcerative Colitis.

Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine

Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…

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Negative / Null Result ReportMedicine

Serum PTH, vitamin D, and calcium levels in patients with medication-related osteonecrosis of the jaw: A case-control study.

Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…

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Negative / Null Result ReportMedicine

The effect of empagliflozin on inflammation and oxidative stress in patients undergoing percutaneous coronary intervention, a randomized controlled trial.

Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports

Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…

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