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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Caffeine Supplementation Increases Muscle Strength, but Not Endurance, While Both Caffeine and Its Expectation Elevate Blood Lactate: A Balanced-Placebo Design Study.

Soares EMKVK, da Cruz CJG, Ives SJ et al. · 2026 · Nutrients

Objectives : To determine whether caffeine supplementation and its expectancy influence muscle strength (ST) and muscle endurance (ME) using a balanced-placebo design. Methods: Using a randomized, double-blind, balanced-placebo design,…

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Negative / Null Result ReportMedicine

Do Respiratory Viruses Cause Leaky Gut Syndrome?

Karataş ŞN, Çağan E, Demirören K et al. · 2025 · Turkish archives of pediatrics

Objective Increased intestinal permeability is associated with the development of allergic and autoinflammatory diseases. Zonulin is a key physiological regulator of tight junctions in the intestinal epithelium. Thymus-expressed chemokine…

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Negative / Null Result ReportMedicine

Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study.

Kloosterman R, Dinh T, Michaeli J · 2026 · Journal of assisted reproduction and genetics

Purpose The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological…

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Negative / Null Result Report

Effect of insect exclusion screens on insect pests in high tunnels

Quesada CR, Batson C, Holaskova I et al. · 2025 · Preprint

Abstract High tunnels can use insect exclusion screens as a mechanical pest control method within integrated pest management (IPM) programs. The impact of insect screens was evaluated on several tomato pests in commercial high tunnels. The…

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Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitors Did Not Exacerbate Autoimmune Rheumatic Disease Activity in Patients With Cancer.

Tsai PH, Hsieh CI, Kuo YC et al. · 2026 · Journal of the National Comprehensive Cancer Network : JNCCN

Background The safety of immune checkpoint inhibitors (ICIs) in patients with cancer and preexisting or acquired autoimmune rheumatic diseases (ARDs) remains unclear. This study aimed to evaluate the safety of ICIs in patients with cancer…

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Negative / Null Result ReportMedicine

Evaluation of a web-based self-monitoring application (MyRA) to empower people with rheumatoid arthritis in daily life.

Hochstenbach LMJ, Verbeek JGE, Brokken-Peters MBJ et al. · 2026 · Rheumatology (Oxford, England)

Objectives To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness. Methods MyRA was co-developed with patients and used at their own discretion during a 4-month…

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Negative / Null Result ReportMedicine

[Deep learning-based assessment of periodontal ligament area changes in maxillary central incisors under different orthodontic regimens using cone beam CT images].

Li RQ, Su S, Zhan LP et al. · 2026 · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

Objective: To investigate the differences in the changes of periodontal ligament area (PDLA) and related clinical indicators before and after maxillary central incisor movement under different orthodontic treatment regimens. Methods: This…

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Negative / Null Result ReportMedicine

Using Social Media to Increase Participation in Universal Free School Meal Programs: An RCT With Parents of Elementary-Aged Children.

Grummon AH, Zeitlin AB, Lee CJY et al. · 2026 · American journal of preventive medicine

Introduction As of 2025, 9 states have adopted Universal Free School Meal programs. The success of these programs depends in part on high participation. This study tested whether a social media campaign promoting school meal participation…

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Negative / Null Result ReportOpen accessMedicine

Multidisciplinary prospective study of standardized pelvic lymph-node dissection focusing on the dorsal obturator nerve region.

Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology

Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…

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Negative / Null Result ReportMedicine

Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle.

Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…

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Negative / Null Result ReportMedicine

Factors Affecting the Intrafollicular Transfer of Immature Oocytes in Beef Heifers: Does the Injection Matter?

de Faria OAC, Kussano NR, de Faria LC et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

This study aimed to evaluate whether the quality of injection and number of oocytes injected during Intrafollicular Transfer of Immature Oocytes (IFIOT) affect ovulation timing, follicle dynamics, oocyte recovery, nuclear maturation and in…

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Negative / Null Result ReportMedicine

Effect of hydrogen peroxide on microcystin-LR from Microcystis sp.

Ng PH, St-Hilaire S · 2025 · Diseases of aquatic organisms

Microcystis spp. blooms in fish ponds can lead to fluctuations in water parameters, and the microcystin-LR (MC-LR) toxin they produce may pose health risks for fish, as well as consumers. Hydrogen peroxide (H2O2) treatment has been…

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Negative / Null Result ReportMedicine

Minimal Movement Restrictions Do Not Increase Hip Dislocations Following Total Hip Arthroplasty: A Before-and-After Study of 10,357 Patients.

Klaassen AD, Willigenburg NW, Musters JWQ et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Hip dislocation is the most common reason for early revision after total hip arthroplasty (THA). To prevent dislocation, patients are often prescribed movement restrictions following THA; however, these restrictions can be…

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