19,850 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Cadiz MRM, Amin-Ong AJ, Prodigalidad-Jabson LT · 2026 · Preprint
Objective: To determine the incidence and risk factors associated with mesh erosion in urogynecologic procedures performed over a ten-year period in a tertiary training hospital in the Philippines. Design: Retrospective cohort study.…
View details →Vasiliu RD, Porojan L, Bejan FR et al. · 2026 · Polymers
The optical stability and aesthetic performance of dental polymers are critical for the longevity of restorative treatments. This study aims to evaluate the influence of different polymerisation conditions and maintenance…
View details →Fan S · 2026 · Preprint
Abstract Objective This research aims to explore the causes of flatfoot, hallux valgus, and accessory navicular conditions within this specific group by conducting a digital morphological examination of foot CT scans from adolescents…
View details →Yaka H, Küçükşen MF, Adem A et al. · 2026 · Early human development
Background Adolescent idiopathic scoliosis (AIS) exhibits a marked sexual dimorphism, with females up to ten times more likely than males to develop curves exceeding 30°, strongly implicating sex hormone signalling in its pathogenesis. The…
View details →Watheq Thabet Taher, Amen A. Bawazir, Talal A. Sallam et al. · 2023 · BMC Infectious Diseases
Abstract Background Healthcare workers (HCWs) are at a higher risk of contracting COVID-19 due to their close contact with infected patients. However, the true burden of COVID-19 among HCWs in Yemen is unknown due to the inadequate availability of healthcare and the subclinical nature of the disease. This study aims to estimate the seroprevalence of SARS-CoV-2 infection among HCWs in two Yemeni governorates and identify associated factors using a cross-sectional design. Method A total of 404 HCWs were surveyed from June 2022 to September 2022 in Lahj and AL-Dhalea hospitals. A self-administere
View details →Abida Shaheen, Syed Mahboob Alam, Fahad Azam et al. · 2022 · PLoS ONE
Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani po
View details →Al-mustafa Mahmoud, Massad Islam, Alsmady Moaath et al. · 2010 · Saudi Journal of Kidney Diseases and Transplantation
Vertical infraclavicular brachial plexus block is utilized in patients with chronic renal failure at the time of creation of an arterio-venous fistula (AVF). The aim of this study is to test the effect of impaired renal function, with the resulting deranged serum electrolytes and blood gases, on the success rate and the onset of action of the local anesthetics used. In this prospective clinical study, we investigated the effect of the serum levels of sodium, potassium, urea, crea-tinine, pH, and bicarbonate on the onset of action of a mixture of lidocaine and bupivacaine administered to create
View details →Cécile Gonnin, Michelle Leemans, Florence Canoui-Poitrine et al. · 2024 · Immunity & Ageing
Abstract Background Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 201
View details →Yina Piao, Mengxia Jin · 2026 · Therapeutic Advances in Endocrinology and Metabolism
Background: Stress-induced hyperglycemia ratio (SHR) has shown strong correlations with diabetes risk. However, its relationship with gestational diabetes mellitus (GDM) remains an area of limited research. Objective: Based on the National Health and Nutrition Examination Survey (NHANES) database, this cross-sectional study aims to explore the association between SHR and GDM. Methods: The study included 461 pregnant women from NHANES between 1999 and 2016. Logistic regression analysis was performed to investigate the relation between SHR and GDM, as well as the weighted tertiles of SHR. Strati
View details →Tony H. Chang, Julie D. Pourtois, Naomi L. Haddock et al. · 2025 · mSphere
ABSTRACT Lysogenic bacteriophages can integrate their genome into the bacterial chromosome in the form of a prophage and can promote genetic transfer between bacterial strains in vitro. However, the contribution of lysogenic bacteriophages to the incidence of antimicrobial resistance (AMR) in clinical settings is poorly understood. Here, in a set of 186 clinical isolates of Pseudomonas aeruginosa collected from respiratory cultures from 82 patients with cystic fibrosis, we evaluate the links between prophage counts and both genomic and phenotypic resistance to six anti-pseudomonal antibiotics:
View details →Selma Celen Yuceturk, Sumeyye Aydogan Turkoglu, F. Kockar et al. · 2021 · Zeitschrift für Naturforschung C - A Journal of Biosciences
Abstract In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using…
View details →Song Cai, SiYu Li, YaShi Zhou et al. · 2024 · BMC Oral Health
Abstract Background Sedentary behavior (SB) may contribute to obesity and lower extremity fluid retention, which may favor the development of obstructive sleep apnea (OSA). However, linking sedentary behavior to OSA is unclear. The purpose of this study was to determine if there is an association between SB and OSA. Methods Three typical questions in the NHANES questionnaire(①The frequency of feeling excessively sleepy per month. ②The frequency of gasping, snorting or stopping breathing per week. ③The frequency of snoring per week.) have been used for the assessment of OSA. A physical activity
View details →Jie Gao, Linting Wei, Xinghan Liu et al. · 2017 · Kidney & Blood Pressure Research
Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between
View details →Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
View details →Sung Ui Jung, Kwang Kuk Park, Song I Yang et al. · 2014 · Korean Journal of Clinical Oncology
Purpose: Mutations in the p53 gene and accumulation of p53 protein are the most common genetic events in gastric carcinomas. This study evaluates the association of p53 gene expression with clinicopathologic findings and prognosis of gastric cancer patients who underwent curative resection. Methods: Retrospective analysis was performed on 236 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between December 2011 and September 2012. Nuclear p53 expression was detected by immunohistochemistry. Results: p53 expression was detected in 213 patie
View details →Zoya maqsood , Shahid Jamal Siddiqui, Nimarta Bai et al. · 2025 · Journal of the Dow University of Health Sciences
Objective: To determine the frequency of raised intraocular pressure (IOP) following neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy in pseudophakic patients and to compare outcomes between high- and low-energy procedures. Methods: This descriptive cross-sectional study was conducted at the Department of Ophthalmology, Khairpur Medical College / Civil Hospital, Khairpur Mirs, Pakistan from April to September 2024. A total of 139 pseudophakic patients with posterior capsular opacification (PCO) undergoing Nd:YAG capsulotomy were enrolled. Baseline demographic and clinical dat
View details →Sepehr Feizi, Mohammad Ali Javadi · 2019 · Journal of Ophthalmic & Vision Research
Purpose: To evaluate the effects of donor graft thickness on postoperative best spectacle-corrected visual acuity (BSCVA), refractive outcomes, endothelial cell density (ECD) and function, intraocular pressure (IOP), and postoperative complications after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This retrospective, interventional case series enrolled 77 eyes of 64 patients who underwent DSAEK with or without simultaneous cataract surgery. Clinical outcomes, including BSCVA, refraction, keratometric astigmatism, IOP, and ECD were assessed at the final follow-up exa
View details →Ridha Ramayanti · 2017 · The Indonesian Journal of Occupational Safety and Health
ABSTRACT Work fatigue is condition which some factors have interaction with the workers. Fatigue may occur in the workforce by various factors, such as nutritional status and work climate. This study was conducted to analyze the relationship between nutritional status and work climate with work fatigue in Hikmah Food Catering. This was an observational analytic study using a cross sectional design. Samples size 43 peoples were taken by simple random sampling method. The correlation between the dependent and independent variables were analyzed by spearman correlation test (α = 0,05). Work clima
View details →Yoriko Heianza, Lu Qi, Marly Augusto Cardoso et al. · 2020 · BMJ Open Diabetes Research & Care
Exposure to different air pollutants has been linked to type 2 diabetes mellitus, but the evidence for the association between air pollutants and gestational diabetes mellitus (GDM) has not been systematically evaluated. We systematically retrieved relevant studies from PubMed, Embase, and the Web of Science, and performed stratified analyses and regression analyses. Thirteen studies were analyzed, comprising 1 547 154 individuals from nine retrospective studies, three prospective studies, and one case–control study. Increased exposure to particulate matter ≤2.5 µm in diameter (PM2.5) was not
View details →Ayman Mohammed Baabdullah, Abdulmalik Ghassan Abumohssin, Yara Aedh Alqahtani et al. · 2019 · Journal of Nature and Science of Medicine
Background: The use of smartphones has increased exponentially. Excessive usage of smartphones has been shown to have a negative impact on ocular health. This study aimed to evaluate the relationship between smartphone addiction and dry eye disease (DED) and determine the risk factors of DED in participants associated with smartphone addiction. Materials and Methods: This cross-sectional study was conducted in May 2017. Participants were selected from the Faculty of Medicine at King Abdulaziz University in Jeddah, Saudi Arabia. Stratified random sampling technique was used to recruit participa
View details →Jenny Brouwer, Radboud J. E. M. Dolhain, Johanna M. W. Hazes et al. · 2019 · ACR Open Rheumatology
Objective Subfertility, a time to pregnancy (TTP) longer than 12 months, is present in 40% of female patients with rheumatoid arthritis (RA) who are actively trying to conceive. Because patients with RA appear to reach menopause at a younger age, diminished ovarian function may explain the reduced fertility. Serum anti‐Müllerian hormone (AMH) levels are the best proxy to measure ovarian function. Our objectives were to study AMH levels in female patients with RA and determine the association of preconception serum AMH levels with TTP. Methods A post hoc analysis was performed before conception
View details →Cristina Novo-Rodríguez, Beatriz García-Fontana, Juan De Dios Luna-Del Castillo et al. · 2018 · PLoS ONE
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% fem
View details →Stefanus Mendes Kiik, Muhammad Saleh Nuwa · 2021 · Jurnal Keperawatan Indonesia
Children with stunting in Indonesia and other low-middle countries remains a serious problem. This study aimed to identify the association between maternal education, maternal age, maternal height, preceding birth interval, and ANC clinic visits and stunting among vulnerable children in Kupang Regency, Indonesia. A cross-sectional study was conducted of two villages in Kupang Regency. The study sample comprised female ex-refugees from Timor Leste who had children aged 24–59 months. The subjects were chosen using consecutive sampling, with a total number of 154. Data were collected from both pr
View details →Ximena Baez-Navarro, Nadine S. van den Ende, Anh H. Nguyen et al. · 2024 · Breast Cancer Research
Abstract Most patients with triple-negative breast cancer (TNBC) are not candidates for targeted therapy, leaving chemotherapy as the primary treatment option. Recently, immunotherapy has demonstrated promising results in TNBC, due to its immunogenicity. In addition, a novel antibody–drug conjugate, namely, trastuzumab-deruxtecan, has shown effectiveness in TNBC patients with low-HER2 expression (HER2-low). These novel treatment options raise the question about the potential association between the density of stromal tumor-infiltrating lymphocytes (sTILs) and the level of HER2 expression. We a
View details →I. Jug, D. Jug, M. Sabo et al. · 2011 · Turkish Journal of Agriculture and Forestry Sciences
Eight different soil tillage systems (TS) for winter wheat after soybean crop production were compared at the chernozem soil type in Croatian Baranya region in a 4-year period (2001/2002, 2002/2003, 2003/2004, 2004/2005). Tillage systems…
View details →Margaret Diana , Deviana Soraya Riu, Fatmawati Madya et al. · 2025 · Obgynia
Objective: This study aimed to investigate the impact of SHS exposure on fetal biometry and umbilical artery flow at 24 – 28 weeks of gestation. Methods: This cross-sectional study included 110 pregnant women, divided into a study group (55 passive) smokers and a control group (55 non-passive smokers). Serum cotinine levels were measured using ELISA. Fetal biometry (biparietal diameter, head circumference, abdominal circumference, and femur length) and umbilical artery flow (pulsatility and resistance indices) were assessed via ultrasound and Doppler ultrasonography. Group comparisons were con
View details →Souvik Sardar, Somenath Sarkar, Indrashis Podder et al. · 2022 · Indian Journal of Dermatology
Background: Primary scarring alopecias (PSAs) are a rare group of dermatological disorders with overlapping clinical features. They result in permanent hair loss and significant psychological morbidity. Aims: To analyze the clinico-epidemiology of PSAs of the scalp, along with clinico-pathological correlation. Methods: We conducted a cross sectional, observational study including 53 histopathologically confirmed cases of PSA. Clinico-demographic parameters, hair care practices, and histologic characteristics were noted and statistically analyzed. Results: Among 53 patients (mean age 30.9 ± 8.1
View details →Brajušković G., Nikolić Zorana, Kojić A. et al. · 2013 · Archives of Biological Sciences
Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS identified 8q24 as one of the most significant PCa-associated regions. The aim of this study was to evaluate the association of SNP rs378854 at 8q24 with PCa risk in the Serbian population. The study population included 261 individua
View details →Nissar Shaikh, Huda Al Mahdi, Anant Pai et al. · 2022 · Annals of Medicine
Introduction COVID-19 patients presenting with ocular manifestations are from 0.8% to 32% of patients seen in the ED. The available literature is scarce regarding COVID-19 patients presenting with ocular manifestations from the Middle Eastern region. Purpose This study aims to report the incidence of ocular signs and symptoms in COVID-19 patients and find any correlation between the occurrence of ocular manifestations and patients’ comorbidities. Methods All patients having the primary diagnosis of COVID-19 infection and concurrent ocular manifestations on admission to our tertiary COVID-19 he
View details →Kiho Sung, Junsol Kim, Yeong-Ran Park et al. · 2026 · Scientific Reports
Abstract Cardiovascular disease (CVD) is prevalent among older adults, but studies often focus on individual spouses rather than couple dynamics. This study examines how interplay between spouses—specifically discordance in gender role attitudes—relates to CVD risk biomarkers, using couple-matched data from the Korean Social Life, Health, and Aging Project (KSHAP) on 308 older married couples (616 individuals). Actor-partner interdependence models (APIM) reveal that discordant gender role attitudes are significantly associated with higher CVD risk markers—higher systolic blood pressure, higher
View details →