20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Yu Q, Zeng L, Chen Z et al. · 2026 · Preprint
Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial…
View details →Kam MK, Kim JW, Choi JY et al. · 2026 · Biochemical and biophysical research communications
Tau aggregation in neurons is a pathological hallmark of Alzheimer's disease (AD). The development of therapeutic drugs that inhibit tau aggregation in tauopathies, including AD, remains challenging. Herein, we developed a tau…
View details →Lopez DE, Carmalt JL · 2026 · Frontiers in veterinary science
Background The equine temporomandibular joint (TMJ) is divided into two non-communicating joint (discotemporal DTJ and discomandibular DMJ) compartments. Ultrasound has been extensively used as a diagnostic tool in the horse, but previous…
View details →Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume
Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…
View details →Giaccari LG, Brunetti S, Coppolino F et al. · 2026 · Medical sciences (Basel, Switzerland)
Background : Obesity increases the risk of postoperative pulmonary complications (PPCs), and active smoking may further amplify this risk. Whether smoking status identifies a subgroup of obese surgical patients with differential PPC risk…
View details →Zhao H, Shin D, Tucker E et al. · 2026 · Preprint
Aldoximes are amino acid-derived metabolites that serve as precursors of auxins and modulate phenylpropanoid production in Arabidopsis. However, the enzymes responsible for aldoxime production in Solanaceae remain unknown. Here, we report…
View details →Jdidi H, de Bisschop C, Dugué B et al. · 2026 · European journal of applied physiology
Purpose Whole-body cryostimulation (WBC) has recently been shown to improve autonomic nervous control of the cardiovascular system. This study aimed to investigate the acute and repeated effects of WBC on baroreflex sensitivity (BRS),…
View details →Pittmann R, Herring E, Pennington S et al. · 2026 · Frontiers in health services
Introduction Telehealth etiquette refers to professional behaviors that support effective virtual communication between patients and providers. While telehealth has become a lasting part of healthcare delivery, most health professions…
View details →Glenthøj LB, Vernal DL, Mariegaard LS et al. · 2026 · Schizophrenia (Heidelberg, Germany)
Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these…
View details →Brar MS, Park JJ, de Buck van Overstraeten A · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Background and aims Fertility and mode of delivery are major concerns for women with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA). Although infertility after IPAA has been attributed to pelvic adhesions, the…
View details →Caunca M, Gutierrez S, Wheeler K et al. · 2026 · Neurology
Background and objectives The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the…
View details →Parlak Insel B, Guven Y, Sepet E et al. · 2026 · BMC oral health
Within the concept of minimal invasive dentistry, the progression of initial caries lesions can be inhibited with preventive measures. This study evaluated the microleakage and remineralization potential of a bioactive fissure sealant (FS)…
View details →Duje ML, Scharlovsky HR, Crivelli A et al. · 2026 · Nutricion hospitalaria
Background home enteral nutrition (HEN) maintains nutritional status in patients unable to feed orally. While established globally, data on its costs in Argentina are scarce. This study aimed to describe HEN costs and analyze differences…
View details →Takeda Y, Sakakibara T, Horiuchi K et al. · 2026 · Brain & development
Background We previously reported that adrenocorticotropic hormone (ACTH) therapy for infantile epileptic spasm syndrome (IESS) decreases plasma fibrinogen (Fbg) levels. However, the underlying mechanism(s) has not been elucidated. An…
View details →Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry
To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…
View details →Shaposhnikov MM, Trmcic A, Martin NH · 2026 · Journal of dairy science
The microbial quality of fluid milk is improved via processing steps, such as pasteurization which reduces the overall microbial population of milk and in particular is effective against Gram-negative, heat sensitive bacteria. Therefore,…
View details →Cook DP · 2025 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Pulmonology: [Formula: see text].
View details →Cirlak A, Kacan H · 2026 · Irish journal of medical science
BACKGROUND: Parent-supported psychosocial development programs aim to strengthen the parent-child relationship and promote healthy early childhood development, particularly in settings where access to structured preventive interventions is…
View details →Li J, Dai W, Alavi R et al. · 2026 · Journal of the American Heart Association
Background Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has demonstrated cardioprotective and neuroprotective effects in preclinical myocardial infarction (MI) and ischemic stroke settings by reducing acute myocardial and…
View details →Sosnowski KJ, Ranse KL, Mitchell ML et al. · 2026 · Critical care medicine
Objectives To test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian…
View details →Thorman IB, Sacknovitz A, Li AG et al. · 2026 · Annals of neurology
Objectives The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI). Methods This retrospective cohort study used the…
View details →Niiya F, Satoh T, Kobayashi Y et al. · 2026 · Digestive diseases and sciences
Background Clinical evidence on whether acute cholangitis accelerates early stent failure via rapid bacterial adhesion and biofilm formation remains limited. We assessed the influence of pre-endoscopic retrograde cholangiopancreatography…
View details →Chow EJ, Chen Y, Yasui Y et al. · 2026 · JAMA network open
Importance Survivors of childhood cancer have an increased risk of cardiovascular disease (CVD). However, many survivors at high risk do not receive recommended CVD screening tests as young adults. Objective To assess whether a…
View details →Nersesian G, Rauch M, Lewin D et al. · 2026 · Artificial organs
Background Surgically implanted microaxial flow pumps (mAFP) are increasingly used for cardiogenic shock treatment. Standard mAFP explantation is performed bedside with a shortening of the vascular prosthesis, which may represent a…
View details →Maier LE, Douglas A, Foster K et al. · 2026 · The Journal of physiology
Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. We investigated whether (i) arterial chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii) pulmonary stretch, (iv)…
View details →Na K, Qiu MH, Wang ZH et al. · 2026 · Zhonghua xin xue guan bing za zhi
Objective: To evaluate the efficacy and safety of ticagrelor versus clopidogrel in real-world patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRF-less) following percutaneous coronary…
View details →Cui J · 2025 · Family process
Adverse childhood experiences (ACEs) are significant public health concerns with long-term consequences for children's mental health, physical well-being, and socioeconomic outcomes. This study examines whether younger maternal age at…
View details →de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors
Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…
View details →Rouphael C, Saliba E, Moukarzel M et al. · 2026 · Respiratory care
Background High-flow nasal cannula (HFNC) is a noninvasive oxygenation method that delivers humidified and heated oxygen mixtures at high flows while generating PEEP. Therefore, its use during endoscopic procedures with intravenous deep…
View details →Vaz CSL, Voss-Rech D, da Fonseca FN et al. · 2026 · Foodborne pathogens and disease
Oral phage therapy is a promising strategy for reducing harmful bacteria in broilers. However, it may lead to the spread of therapeutic phages in the farm environment, potentially increasing bacterial host tolerance. To determine the…
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