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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of a shared decision-making implementation programme on patient-centred communication in oncology-Secondary analysis of a randomised controlled trial.

Lindig A, Mannagottera L, Hahlweg P et al. · 2024 · Health expectations : an international journal of public participation in health care and health policy

Background There is a need for better implementation of patient-centred (PC) communication and shared decision-making (SDM) in routine cancer care. Objective The aim of this study was to assess whether a programme to implement SDM in…

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Negative / Null Result ReportMedicine

"CRANIOQUALITY study: Quality of life in children with non-syndromic craniosynostosis after surgery".

Mechdoud S, Berton Q, Arrighi M et al. · 2026 · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Background Few studies have examined the quality of life (QOL) of children undergoing surgery for non-syndromic craniosynostosis (NSC), with no age-specific assessment in France. Objective The CRANIOQUALITY study aimed to assess QOL across…

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Negative / Null Result ReportMedicine

Task Instructions Significantly Affect Maximum Phonation Time.

Baker CP, Miles A, Allen J · 2026 · Journal of voice : official journal of the Voice Foundation

Introduction Maximum phonation time (MPT) is a widely used clinical measure for assessing the effects of voice disorder on vocal function as well as pre-/post-treatment effects. Although its cost-effective nature makes MPT an appealing…

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Negative / Null Result ReportMedicine

Multiple-Birth Family Knowledge in Maternity and Child Health Clinics: Filling Knowledge Gaps to Improve Multiple-Birth Family Nursing.

Heinonen K, Kaprio J, Trias T et al. · 2026 · Twin research and human genetics : the official journal of the International Society for Twin Studies

The purpose of this cross-sectional study was to investigate knowledge about multiple-birth families among midwives and public health nurses working in maternity and child health clinics in Finland. The data were collected with a Finnish…

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Negative / Null Result ReportMedicine

Absence of osteoclastogenic response to pooled polyclonal anti-citrullinated peptide/protein antibodies from patients with rheumatoid arthritis in vitro.

Chen X, An Z, Li C et al. · 2026 · Clinical and experimental medicine

Anti-citrullinated peptide/protein antibodies (ACPAs) are specific serological markers for rheumatoid arthritis (RA), but their direct role in promoting osteoclastogenesis remains controversial. This study aims to determine whether…

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Negative / Null Result Report

Effects of Partial Replacement of Wheat Bran with Poplar Wood Composite Fiber on Growth Performance, Nutrient Apparent Digestibility, Immune Function, and Gut Microbiota in Growing Pigs

Fan Y, Gao G, Jiang X et al. · 2026 · Preprint

The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…

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Negative / Null Result ReportMedicine

Bruxism, temporomandibular disorders, and pressure pain thresholds during fixed orthodontic treatment in adults: A prospective controlled cohort study.

Incerti Parenti S, Evangelisti E, Maglioni A et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To investigate whether fixed orthodontic treatment affects sleep and awake bruxism activities, temporomandibular disorder (TMD) prevalence, and pressure pain thresholds (PPTs) of masticatory muscles in healthy adults. Methods In…

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Negative / Null Result ReportMedicine

Calcium Hydroxide Associated With Chitosan Nanoparticles and Propolis: Effects on the Sealer-Dentin Interface.

Jacob G, Lourenço PR, Diniz FMM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective This study evaluated the effect of calcium hydroxide-based intracanal medication protocols on the sealer-dentin interface, considering bond strength, adhesive interface adaptation, failure pattern, and dentin gelatinolytic…

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Negative / Null Result ReportMedicine

Eight-Week Minimal Dose Training Reduces Premenstrual Syndrome Symptoms but Does Not Influence Coping Strategies: A Nonrandomized Study.

Soares EADS, Crisp AH, Fernandes PT et al. · 2026 · Scandinavian journal of psychology

Premenstrual syndrome (PMS) is a set of symptoms related to hormonal changes occurring during the premenstrual period. Effective coping strategies for managing PMS have not been clearly established, and it remains unclear whether these…

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Negative / Null Result ReportMedicine

Impact of Far-Infrared-Radiation on the Proportion of Interventions in Arteriovenous Fistulas in Patients on Hemodialysis: A Randomized Trial.

Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN

Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…

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Negative / Null Result ReportMedicine

A Retrospective Analysis of Perinatal Stroke: Hemostasis Abnormalities, Neonatal Seizures, Epilepsy Recurrence, and 2-Year Neurological Outcome.

Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics

Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…

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