Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Robert G Maki, Martina Bradic, Phillip Wong et al. · 2025 · Journal for ImmunoTherapy of Cancer
Background Objective responses to immune checkpoint inhibitors (ICI) in leiomyosarcoma (LMS) are rare. Response rates may be increased by combination with other drugs known to promote immune infiltration, such as poly(ADP-ribose) polymerase (PARP) inhibitors, which have led to benefit in BRCA-altered uterine LMS. We therefore evaluated the combination of a PARP inhibitor, rucaparib, and the anti-programmed death receptor-1 monoclonal antibody, nivolumab, in patients with advanced LMS and investigated its effects on the tumor immune microenvironment.Methods This was an open-label, single-center
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Emily E. Bray, Emily E. Bray, Kerinne M. Levy et al. · 2019 · Frontiers in Veterinary Science
Assistance dogs can greatly improve the lives of people with disabilities. However, a large proportion of dogs bred and trained for this purpose are deemed unable to successfully fulfill the behavioral demands of this role. Often, this determination is not finalized until weeks or even months into training, when the dog is close to 2 years old. Thus, there is an urgent need to develop objective selection protocols that can identify dogs most and least likely to succeed, from early in the training process. We assessed the predictive validity of two candidate measures employed by Canine Companio
View details →Negative / Null Result ReportOpen accessMedicine
Kwak N, Kim JY, Kim HJ et al. · 2025 · Tuberculosis and respiratory diseases
Background This study aimed to determine whether a shorter high-dose rifampicin regimen is non-inferior to the standard 6-month tuberculosis regimen. Methods This multicenter, randomized, open-label, non-inferiority trial enrolled…
View details →Negative / Null Result ReportOpen accessMedicine
José María Paredes, Tomás Ripollés, Ángela Algarra et al. · 2022 · Intestinal Research
Background/Aims Tight control of inflammation and adjustment of treatment if activity persists is the current strategy for the management of Crohn’s disease (CD). The usefulness of fecal calprotectin (FC) in isolated involvement of the small intestine in CD is controversial. To assess the usefulness of FC to determine the inflammatory activity detected by intestinal ultrasonography (IUS) in ileal CD. Methods Patients with exclusively ileal involvement CD who underwent IUS and an FC were prospectively included. Simple ultrasound index was used to determine inflammatory activity. The usual stati
View details →Negative / Null Result ReportOpen accessPathology
Menk M, Graw JA, von Haefen C et al. · 2018 · Journal of Inflammation Research
Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany Purpose: Although the role of the angiotensin II type 2 (AT2) receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Pannipa Suwannasom, Tasalak Thonghong, Krit Leemasawat et al. · 2024 · Journal of Diabetes Investigation
Abstract Aims/Introduction Individuals with diabetes are at high risk of developing cardiovascular events. The present study investigated the predictive value of the cardio‐ankle vascular index (CAVI) when added to the Systematic Coronary Risk Evaluation 2‐Diabetes (SCORE2‐Diabetes) risk algorithm to predict cardiovascular events in the Asian population. Materials and Methods The SCORE2‐Diabetes risk was assessed in 1,502 patients with diabetes, aged 40–69 years. Then, we further stratified each 10‐year risk category with a CAVI value of 9.0. The primary outcomes (composite of all causes of de
View details →Negative / Null Result ReportOpen accessMedicine
Sung Yoon Lim, Kyu Jin Lee, Yeonhoon Jang et al. · 2025 · The Korean Journal of Internal Medicine
Background/Aims Despite some evidence supporting its utility, the role of adjunctive dobutamine in the management of septic shock remains unclear. Methods The nationwide prospective sepsis cohort of the Korean Sepsis Alliance was analyzed. Adult patients with septic shock receiving norepinephrine were enrolled over a 29-month period. Patients given a dobutamine infusion within 3 days of intensive care unit (ICU) admission were compared with patients who received no infusion. To balance baseline characteristics, propensity score matching (PSM) was used. Results Of 11,981 patients with sepsis, 1
View details →Negative / Null Result ReportOpen accessPediatrics
Sheldon R. Garrison, Sophie A. Schweinert, Matthew W. Boyer et al. · 2025 · Child and Adolescent Psychiatry and Mental Health
Abstract Background This study evaluated pharmacogenomic (PGx) testing in children and adolescents with autism spectrum disorder (ASD). ASD frequently presents with co-occurring depression and anxiety. This complex phenotype often results in psychotropic medication polypharmacy. Incorporating PGx testing into the medical work-up may reduce polypharmacy and improve quality of life with symptom reduction. Methods A retrospective electronic health record (EHR) review between January 2017 and May 2023. Individuals either received PGx testing or treatment as usual (TAU). The co-primary outcomes wer
View details →Negative / Null Result ReportOpen accessMedicine
Julie Faverial, Denis Cornet, Jacky Paul et al. · 2016 · PLoS ONE
Previous studies indicated that the quality of tropical composts is poorer than that of composts produced in temperate regions. The aim of this study was to test the type of manure, the use of co-composting with green waste, and the stabilization method for their ability to improve compost quality in the tropics. We produced 68 composts and vermicomposts that were analysed for their C, lignin and NPK contents throughout the composting process. Bayesian networks were used to assess the mechanisms controlling compost quality. The concentration effect, for C and lignin, and the initial blend qual
View details →Negative / Null Result ReportOpen accessMedicine
Cardona PJ · 2026 · Frontiers in immunology
Tuberculosis (TB) vaccine development is hindered by the absence of validated correlates of protection, the low proportion of infected individuals who progress to disease, and the pervasive impact of reinfection in endemic settings.…
View details →Negative / Null Result ReportOpen accessForestry
Basave Villalobos E, Alcalá Cetina Víctor M, López López Miguel A et al. · 2015 · iForest - Biogeosciences and Forestry
Swietenia humilis is a valued tree species for its high-quality wood, among other commercial interests. Attempts to plant the species in southwest Mexico have often failed due to poor quality seedlings combined with low soil fertility and dry environments. Nursery top-pruning and fertilization are practices previously reported to improve seedling quality, and facilitate rapid establishment under poor site conditions. In the present study, the effects of three top-pruning intensities (0%, 25%, and 50%), and two fertilizer regimes (traditional and exponential) on several S. humilis seedling morp
View details →Negative / Null Result ReportOpen accessAnimal culture
Giovanni Martemucci, Angela Gabriella D’Alessandro · 2010 · Italian Journal of Animal Science
Three experiments were carried out with the aim of evaluating the efficiency of techniques of in vivo production, storage and transfer of embryos in dairy sheep. Experiment I - For embryo production, thirty-one ewes were synchronized with FGA (vaginal sponges, 40 mg, 9 d) and PGF2α (ICI; 50 μg, 7th d), and subdivided into three groups corresponding to the following superovulatory treatments over 3 days with purified gonadotrophic preparations: A) control, FSH/LH ratio = 1 (250 IU p-FSH : 250 UI p-LH); B) FSH/LH ratio = 2 (250 IU p-FSH : 125 IU p-LH) and daily FSH/LH ratio of 3.4 &ndas
View details →Negative / Null Result ReportOpen accessMedicine
Rosamund Chapman, Michiel van Diepen, Shireen Galant et al. · 2020 · Vaccines
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral glycoproteins has been shown to increase Env spike density on the cell membrane and surface of virus-like particles (VLPs). In this study, chimeric Env antigens were generated by replacing the transmembrane and cytoplasmic domains of HIV-1 Env with the corresponding regions from the influenza H5 hemagglutinin (HA) (gp140HA 2 tr) and by replaci
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Sriyanti Sriyanti, Evy Damayanthi, Faisal Anwar · 2019 · Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition
Background : Rosela (Hibiscus sabdariffa L.) is an anthocyanin-rich plant that has good antioxidant capacity. However, the utilization was limited to red roselle, while previous studies showed that anthocyanin content was found to be higher in the thick roselle.therefore, this is an opportunity to develop purple roselle products as a preventive effort for degenerative diseases in men with fatness. Subjects in this study were male by considering the effect of estrogen on women which could play a role in suppressing oxidative stress. Objectives : This study aimed to analyze antioxidant (SOD/Supe
View details →Negative / Null Result ReportOpen accessMedicine
Duangdee Trangsuwan, Malai Wongchanchailert, Ladda Mo-suwan et al. · 2018 · Journal of Health Science and Medical Research (JHSMR)
Objective: To evaluate the volume of blood transfusion requirements as well as hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E. Material and Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 and September, 2014 in the Pediatric Clinic of Songklanagarind Hospital. The participants were β-thalassemia major and Hb E/β-thalassemia patients aged between 5 and 18 years. A random allocation sequence was generated to receiving either 6 months of vitamin E
View details →Negative / Null Result ReportOpen accessAnimal culture
S. Lürzel, K. Barth, I. Windschnurer et al. · 2018 · Animal
Cattle’s relationship with humans is a crucial factor regarding their welfare. In dairy cows, interactions with humans occur regularly during milking. We tested the effect of gentle interactions (stroking, talking in a gentle voice) during milking on avoidance distance and milk composition, yield and flow characteristics as well as behaviour during milking. Over the course of 15 days, an experimenter interacted gently with 14 German Holstein cows for 2 min during morning and evening milkings, totalling 60 min; the experimenter stayed at a similar distance to 12 control cows of the same breed f
View details →Negative / Null Result ReportOpen accessBotany
Xiang-Gui Chen, Yi-Hua Wu, Neng-Qi Li et al. · 2022 · BMC Plant Biology
Abstract Background Orchids require specific mycorrhizal associations for seed germination. During symbiotic germination, the seed coat is the first point of fungal attachment, and whether the seed coat plays a role in the identification of compatible and incompatible fungi is unclear. Here, we compared the effects of compatible and incompatible fungi on seed germination, protocorm formation, seedling development, and colonization patterns in Dendrobium officinale; additionally, two experimental approaches, seeds pretreated with NaClO to change the permeability of the seed coat and fungi incub
View details →Negative / Null Result ReportOpen accessAgriculture (General)
Jasanmol Singh, Ali Bulent Koc, Matias Jose Aguerre et al. · 2024 · Smart Agricultural Technology
Alfalfa is a high-yielding forage crop that is widely grown in the United States for grazing, hay and silage making. A proper maintenance of these grasslands is necessary to ensure optimum productivity and profits. The pre-harvest estimation of biomass yield helps in quantifying the profits and optimizing the forage allocation in advance. Most traditional methods of forage estimation are relatively laborious and time-consuming. Recent developments in contact and remote sensing technologies opened numerous paths for performing aboveground biomass estimation tasks with flexibility and easiness.
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ophélie Vacca, Amel Saoudi, Mathilde Doisy et al. · 2025 · Molecular Therapy: Nucleic Acids
The mdx52 mouse model exhibits a common mutation profile associated with brain involvement in Duchenne muscular dystrophy (DMD), characterized by heightened anxiety, fearfulness, and impaired associative fear learning. Deletion of exon 52 disrupts the expression of two dystrophins found in the brain (Dp427 and Dp140) and is eligible for therapeutic exon-skipping strategies. We previously demonstrated that a single intracerebroventricular administration of an antisense oligonucleotide (ASO) targeting exon 51 of the Dmd gene could restore 5%–15% of Dp427 expression. This treatment reduced anxiet
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
B. Gurer, S. Cabuk, O. Karakus et al. · 2018 · Journal of Orthopaedic Surgery and Research
Abstract Background Biologic treatment options for cartilage injuries require chondrocyte expansion using cell culture. Clinical application is accomplished in two surgical sessions and is expensive. If isolation of chondrocytes and stimulus for proliferation and extracellular matrix synthesis can be achieved in vivo, the treatment can be performed in one session and the cost can be reduced. Methods A 2.5-cm diameter full-thickness chondral defect was created in the knees of five groups of sheep. In one group, some of the chondral tissues obtained from the creation of the defect were diced int
View details →Negative / Null Result ReportOpen accessMedicine
Da Jun Than, Vinodh Vayara Perumall, Syamim Johan et al. · 2023 · Einstein (São Paulo)
ABSTRACT Post-thoracotomy paraplegia after non-aortic surgery is an extremely uncommon complication. A 56-year-old woman presented with a 1-year history of progressive shortness of breath. Computed tomography revealed a locally advanced posterior mediastinal mass involving the ribs and the left neural foramina. Tumor excision with a left pneumonectomy was performed. Post-resection, bleeding was noted in the vicinity of the T4-T5 vertebral body, and the bleeding point was packed with oxidized cellulose gauze (Surgicel®). Postoperatively, the patient complained of bilateral leg numbness extendin
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Jonas Radermacher, Steffen Thiel, Aimo Kannt et al. · 2025 · BMC Public Health
Abstract Background The COVID-19 pandemic has profoundly affected daily life and posed significant challenges for politics, the economy, and the education system. To better prepare for such situations and implement effective measures, it is crucial to accurately assess, monitor, and forecast the progression of a pandemic. This study examines the potential of integrating wastewater surveillance data to enhance an autoregressive COVID-19 forecasting model for Germany and its federal states. Methods First, we explore the cross-correlations between SARS-CoV-2 viral RNA load measured in wastewater
View details →Negative / Null Result ReportOpen accessMedicine
M. I. Lourenço-Silva, A. Ulans, A. M. Campbell et al. · 2023 · Scientific Reports
Abstract Impacts of environmental complexity on affective states in slow-growing broiler chickens (Gallus gallus domesticus) are unknown. Chickens’ performance in judgment bias tests (JBT) can be limited as they are tested individually, causing fear and anxiety. The objectives were to apply a social-pair JBT to assess the effect of environmental complexity on slow-growing broiler chickens` affective states, and assess the impact of fearfulness, anxiety, and chronic stress on JBT performance. Six-hundred Hubbard Redbro broilers were housed in six low-complexity (similar to commercial) or six hi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Yang H, Gao J, Li S et al. · 2021 · International Journal of General Medicine
Hua Yang,1,* Jian Gao,2,* Shuyu Li,1 Huiling Xia,1 Zhangyan Chen,1 Shanzhu Zhu,1 Zhigang Pan1 1Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, 200030, People’s Republic of China; 2Department of Nutrition, Zhongshan Hospital of Fudan University, Center of Clinical Epidemiology and Evidence-Based Medicine, Fudan University, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shanzhu Zhu; Zhigang PanDepartment of General Practice, Zhongshan Hospital of Fudan University, No. 180, Road Fenglin, Shan
View details →Negative / Null Result ReportOpen accessPediatrics
Chuhan Cheng, Liyan Zhang · 2025 · Clinical and Experimental Pediatrics
Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with various diseases including respiratory conditions. However, the relationship between NLR and asthma in the pediatric population remains underexplored. Purpose This study aimed to explore the association between NLR and asthma in children and adolescents and assess its potential role as a predictive biomarker for pediatric asthma. Methods We retrospectively analyzed the medical records of 12,974 children and adolescents from the National Health and Nutrition Examination Survey in 2011–2020.
View details →Negative / Null Result ReportOpen accessMedicine
Mottaghi T, Askari Gh, Khorvash F et al. · 2015 · مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Migraine is common worldwide. In recent years, vitamin D deficiency has been shown as a global health issue. This study was done to determine the relationship between serum levels of vitamin D with migraine. Methods: This descriptive - analytical study was carried out on 76 patients (21 males, 55 females) with migraine aged 10-61 years olds. Serum vitamin D level of each patient was measured. Adjustments were done for age, sex, waist circumference, body mass index (BMI), number of chronic diseases, and education level. The multiple linear regressions were done to dete
View details →Negative / Null Result ReportOpen accessMedicine
SHINY JOHN, KAVITARATI DHARWADKAR, MANJUNATH V MOTAGI · 2014 · Journal of Clinical and Diagnostic Research
Background: Cholesterol is especially abundant in nervous system, where it plays important role in different aspects of cellular structure (e.g. fluidity of cell membranes) and function (e.g. membrane). Several studies showed that there may be a link between depression and low cholesterol because of altered central serotonergic functions. On the other hand, some studies also showed either no such association or yielded inconsistent results. However, many studies have related low cholesterol with different psychiatric disorders. Hence, we intend to see the possible link between the two. Aim: To
View details →Negative / Null Result ReportOpen accessMedicine
Geum-Bong Lee, Hyunhee Woo, Su-Yoon Lee et al. · 2019 · PLoS ONE
Background and objective Education of disease plays an important role in management of Parkinson's disease (PD). However, little is known about the link between the understanding of disease and the burden of care. This study was carried out to find the correlation between the burden of care and the understanding of disease in caregivers for PD patients. Methods Non-demented patients with PD and their caregivers participated in structured interviews. Understanding of patients and caregivers was evaluated through newly-devised questions. The caregiver burden inventory was used to assess the burd
View details →Negative / Null Result ReportOpen accessBiotechnology
Nga Thi Nguyen, Thanh Thi Ngoc Nguyen, Hue Thi Nguyen · 2025 · Ho Chi Minh City Open University Journal of Science - Engineering and Technology
Breast cancer remains a leading cause of mortality among women worldwide. In Vietnam, the rising incidence underscores the urgent need for early diagnostic markers. Genetic factors, particularly Single Nucleotide Polymorphisms (SNPs), play a critical role in breast cancer susceptibility. The SNP rs34678647, located downstream of the miR-221/222 cluster targeting Estrogen Receptor alpha (ERα), is hypothesized to influence breast cancer risk by modulating cancer-related pathways. This study investigates the association between rs34678647 and breast cancer risk in the Vietnamese population. A tot
View details →Negative / Null Result ReportOpen accessMedicine
Chang Mo Moon, Sung-Ae Jung, Seong-Eun Kim et al. · 2015 · PLoS ONE
Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that ol
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