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Browse the failure-mode index

19,850 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of Synbiotic Supplementation on Blood and Urinary Concentrations of Factors Related to Kidney Stone Formation in Overweight or Obese Patients with Hyperoxaluria: A Randomized Controlled Trial.

Maddahi N, Zamani B, Nadjarzadeh A et al. · 2026 · Urology journal

Purpose This study investigated the impact of synbiotics on blood and urinary concentrations of factors related to kidney stone formation in overweight or obese patients with hyperoxaluria. Materials and methods A randomized double-blind…

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Negative / Null Result ReportMedicine

Simultaneous Assessment of Calcium Signaling and Mitochondria Activity in Human Platelets Using Continuous Flow Cytometry.

Mishukov AA, Ignatova AA, Ogneva AL et al. · 2026 · Cytometry. Part A : the journal of the International Society for Analytical Cytology

Increasing evidence suggests connection between mitochondrial dysfunction and platelet-related disorders, necessitating developing of a high throughput method for assessing the functioning of mitochondria in platelets. Here we develop an…

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Negative / Null Result ReportOpen accessMedicine

Effects of tocilizumab on neutrophil gelatinase-associated lipocalin following out-of-hospital cardiac arrest, and its prognostic value.

Alaoui-Ismaili Z, Grand J, Frydland M et al. · 2026 · Resuscitation plus

Background Early risk assessment is crucial in comatose survivors of out-of-hospital cardiac arrest (OHCA) for timely resource allocation and initiation of interventions. Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory…

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Negative / Null Result ReportMedicine

Metabolic and endocrinological effects of weekly growth hormone replacement therapy with somapacitan in patients with adult growth hormone deficiency after switching from daily growth hormone replacement therapy: A real-world exploratory cohort study.

Abe I, Kubo K, Fujita Y et al. · 2026 · Drug discoveries & therapeutics

The metabolic and endocrinological effects in patients with adult growth hormone deficiency (AGHD) who switched from daily growth hormone (GH) replacement therapy to weekly GH replacement therapy with somapacitan were evaluated and…

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Negative / Null Result Report

Effects of Partial Replacement of Wheat Bran with Poplar Wood Composite Fiber on Growth Performance, Nutrient Apparent Digestibility, Immune Function, and Gut Microbiota in Growing Pigs

Fan Y, Gao G, Jiang X et al. · 2026 · Preprint

The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…

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Negative / Null Result ReportMedicine

Bruxism, temporomandibular disorders, and pressure pain thresholds during fixed orthodontic treatment in adults: A prospective controlled cohort study.

Incerti Parenti S, Evangelisti E, Maglioni A et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To investigate whether fixed orthodontic treatment affects sleep and awake bruxism activities, temporomandibular disorder (TMD) prevalence, and pressure pain thresholds (PPTs) of masticatory muscles in healthy adults. Methods In…

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Negative / Null Result ReportMedicine

Calcium Hydroxide Associated With Chitosan Nanoparticles and Propolis: Effects on the Sealer-Dentin Interface.

Jacob G, Lourenço PR, Diniz FMM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective This study evaluated the effect of calcium hydroxide-based intracanal medication protocols on the sealer-dentin interface, considering bond strength, adhesive interface adaptation, failure pattern, and dentin gelatinolytic…

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Negative / Null Result ReportMedicine

Eight-Week Minimal Dose Training Reduces Premenstrual Syndrome Symptoms but Does Not Influence Coping Strategies: A Nonrandomized Study.

Soares EADS, Crisp AH, Fernandes PT et al. · 2026 · Scandinavian journal of psychology

Premenstrual syndrome (PMS) is a set of symptoms related to hormonal changes occurring during the premenstrual period. Effective coping strategies for managing PMS have not been clearly established, and it remains unclear whether these…

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Negative / Null Result ReportMedicine

Impact of Far-Infrared-Radiation on the Proportion of Interventions in Arteriovenous Fistulas in Patients on Hemodialysis: A Randomized Trial.

Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN

Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…

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Negative / Null Result ReportMedicine

A Retrospective Analysis of Perinatal Stroke: Hemostasis Abnormalities, Neonatal Seizures, Epilepsy Recurrence, and 2-Year Neurological Outcome.

Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics

Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…

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