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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity.

Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine

Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…

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Negative / Null Result ReportMedicine

Bactericidal Efficacy of So-Called Sanitizers in Japan.

Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin

Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…

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Negative / Null Result ReportOpen accessMedicine

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy.

Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine

Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…

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Negative / Null Result ReportMedicine

The Effects of Differential Learning on the Standing Broad Jump.

Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills

In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…

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Negative / Null Result ReportOpen accessMedicine

Preventing relapse in patients with major depressive disorder after an effective acute course of electroconvulsive therapy.

Song M, Launder NH, Phutane VH et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveMajor depressive disorder (MDD) is a highly prevalent debilitating mental health disorder with a lifetime risk of 11-15% in Australia. The most effective treatment for severe depression is electroconvulsive therapy (ECT), but it…

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Negative / Null Result ReportOpen accessMedicine

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial.

Judith PJ, Maureen B, Mélanie P et al. · 2024 · Health science reports

Background In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. Patients/methods A…

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Negative / Null Result ReportOpen accessMedicine

Eosinophilic myocarditis in dilated cardiomyopathy: a case report.

Li M, Chen H · 2025 · BMC cardiovascular disorders

Background Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative…

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Negative / Null Result ReportMedicine

"Back to the Future": Testing the "Individual Problems and Strengths" Scale With a Stepwise Confirmatory Factor Analysis Approach.

Zahl-Olsen R, Gausel N, Håland ÅT et al. · 2026 · Journal of clinical psychology

Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale-reliability to…

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Negative / Null Result ReportMedicine

Lung ultrasound score and prediction of patient outcomes in hypoxaemic intubated and mechanically ventilated critically ill: A cohort study.

Ntoumenopoulos G, Hansell L, Neindre AL et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background The extent of pulmonary aeration present on admission to the intensive care unit (ICU) as determined by the lung ultrasound score (LUSS) may be useful to predict weaning from mechanical ventilation. The aim of this study was to…

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Negative / Null Result ReportMedicine

Longitudinal relations between parental burden, adolescent externalizing symptoms, and mental health service use in the year following adolescent psychiatric hospitalization.

Harris KM, Curby TW, Goldston DB et al. · 2026 · Psychological services

Rates of adolescent psychiatric hospitalization have increased significantly over the last decade. Despite heightened risk for life-threatening behavior and readmission in the year following hospitalization, mental health service use has…

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Negative / Null Result ReportMedicine

Outcome of Severe Adenoviral Respiratory Infection Supported With Extracorporeal Membrane Oxygenation: A Multicenter PICU Study From Colombia (2018-2022).

Acevedo L, Fernández-Sarmiento J, Mulett H et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To compare survival, clinical characteristics, complications, and duration of extracorporeal membrane oxygenation (ECMO) support in pediatric patients with severe adenoviral respiratory infections vs. those with other viral…

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Negative / Null Result ReportOpen accessMedicine

What Is the Impact of Second Language Exposure and Intellectual Disability Status on Executive Function and Functional Communication Outcomes in Children and Adolescents With and Without Autism Spectrum Disorder (ASD)?

Hutchison SM, DiazPinzon N, Oberlander TF et al. · 2025 · Autism research : official journal of the International Society for Autism Research

Over the past 10 years, research has suggested no negative effect on second language exposure in children with autism spectrum disorder (ASD), yet, parents and professionals may be concerned that using a second language with a child with…

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Negative / Null Result ReportOpen accessMedicine

Immune Globulin

· 2006

Immune globulin G (IgG) is a normal component of breastmilk. Data from 2 mothers indicate that IgG concentrations in milk are normal or higher and IgM levels in milk are normal or lower during intravenous immunoglobulin (IVIG) therapy. The…

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Negative / Null Result ReportOpen accessMedicine

Repeated Tetrahydrocannabinol Injections Induce Tolerance but Do Not Disrupt Ongoing Behaviour Upon Withdrawal in Male and Female Rats With Inflammatory Pain.

Morgan MM, Hickey CM · 2026 · European journal of pain (London, England)

Background Many people use cannabis to self-medicate for pain. Little is known about the impact of pain on tolerance and spontaneous withdrawal to delta-9-tetrahydrocannabinal (THC), the primary psychoactive compound in cannabis. Our…

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Negative / Null Result ReportMedicine

Variation in Maternal Effort, Activity Budgets, and Feeding Behavior in Wild Saddleback Tamarins (Leontocebus weddelli) in Northwestern Bolivia.

Erb WM, Porter LM, Voyt R et al. · 2025 · American journal of primatology

Among primates, maternal infant care may vary in response to several factors including litter size, reproductive history, and health status. In cooperative breeders, maternal investment may also depend on the amount of help their group…

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Negative / Null Result ReportMedicine

Transition from classic to expanded Denver screening criteria for blunt cerebrovascular injury: lessons from a high-volume level I trauma center.

Casado-Ruiz J, Castaño-Leon AM, García-Escudero L et al. · 2025 · Journal of neurosurgery

Objective Blunt cerebrovascular injuries (BCVIs) are associated with significant morbidity and mortality. To identify patients with BCVI who were undetected using the classic criteria, researchers designed the expanded Denver screening…

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Negative / Null Result ReportMedicine

Childhood poverty and its impact on financial decision making under threat: A preregistered replication of Griskevicius et al. (2011b).

Gladstone JJ, Lehman M, Decker M · 2025 · Journal of experimental psychology. Applied

We investigated the influence of childhood poverty on financial decision making under threat by replicating the findings of Griskevicius et al. (2011b), which found that individuals from lower socioeconomic backgrounds tend to make riskier…

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Negative / Null Result ReportOpen accessMedicine

A Comparison of Vessel Density in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Patients Using OCT Angiography.

Zehavi-Dorin T, Kutzscher AE, Badr M et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare global peripapillary and perifoveal vessel densities between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients with the same glaucoma severity using optical coherence tomography angiography…

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