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Browse the failure-mode index

19,850 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications

Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…

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Negative / Null Result ReportOpen accessMedicine

The sonographic Murphy sign: does analgesia matter?

Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology

Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…

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Negative / Null Result Report

Decline of PD-L1 Immunoreactivity with Storage Duration in Formalin-Fixed Paraffin-Embedded Breast Cancer Specimens: Implications for Diagnostic Accuracy and Immunotherapy Eligibility in Triple-Negative Breast Cancer

Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Preprint

Backgrounds: . Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…

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Negative / Null Result ReportMedicine

Underutilization of fentanyl testing masks substantial fentanyl exposure in routine urine drug screens in Indiana.

Olaniyan H, Beckman J, Crosby E et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry

Objectives Timely and locally relevant drug testing is helpful for overdose assessment; however, immunoassay (IA)-based urine drug screens (UDS) often fail to detect emerging substances. This study assesses fentanyl screen utilization and…

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Negative / Null Result ReportMedicine

Clinical significance of negative BioFire® pneumonia panel in ICU: Diagnosis, management, and outcomes.

Nardy T, Rondinaud E, Dessajan J et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives This study assessed the clinical significance of negative BioFire® FilmArray® Pneumonia Panel (FA-PP) results in ICU patients with suspected hospital-acquired (HAP) or ventilator-associated pneumonia (VAP), evaluating its impact…

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Negative / Null Result ReportMedicine

A critical review of styrene and styrene-7,8-oxide genotoxicity literature: an update.

Pottenger LH, Banton M, Barranco WT et al. · 2026 · Journal of environmental science and health. Part C, Toxicology and carcinogenesis

Recent studies investigating mutagenic/cytogenetic effects of styrene and styrene-7,8-oxide (SO) were reviewed to update published critical evaluations of these data from 2019. Transcriptomics studies relevant to styrene/SO genotoxicity…

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Negative / Null Result ReportMedicine

Accuracy of Digital Radiography and Cone Beam Computed Tomography in Assessing Filling Material Extrusion Using Micro-Computed Tomography as Gold Standard: A Study in Human Cadavers.

Monteiro T, Romeiro K, Brisson-Suárez K et al. · 2026 · European endodontic journal

Objective This study compared the accuracy of digital periapical radiography (DPR) and cone beam computed tomography (CBCT) in detecting extruded filling material, using a human cadaver model. Micro-computed tomography (Micro-CT) served as…

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Negative / Null Result ReportMedicine

Toxicological evaluation and risk assessment of Cyclo-di-Badge, a non-intentionally added substance (NIAS), found in epoxy based coatings of food cans.

Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…

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Negative / Null Result ReportOpen accessMedicine

Paucibacillary Pleural Tuberculosis Presenting as Subpleural Nodules: A Diagnostic Challenge With Negative PCR and Smear Tests.

Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports

Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…

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Negative / Null Result ReportMedicine

Diagnostic utility of urinalysis parameters in predicting urine culture positivity: A gender-stratified evaluation.

Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…

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Negative / Null Result ReportOpen accessMedicine

Association between the extent of intrapulmonary spread on chest CT and false-negative results of T-SPOT.TB in pulmonary tuberculosis: a retrospective study.

Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases

Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…

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Negative / Null Result ReportOpen accessMedicine

Enhanced serodiagnosis of opisthorchiasis using a multi-epitope dot-ELISA: comparative evaluation of visual and imageJ-assisted analysis of IgG and IgM responses.

Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases

Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…

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Negative / Null Result ReportOpen accessMedicine

Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.

Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine

Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…

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Negative / Null Result ReportMedicine

Phase 2 Single-arm Trial of Primary Retroperitoneal Lymph Node Dissection in Patients with Seminomatous Testicular Germ Cell Tumors with Clinical Stage IIA/B (PRIMETEST).

Hiester A, Che Y, Lusch A et al. · 2023 · European urology

Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…

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Negative / Null Result ReportMedicine

Innovation in Personal Protective Equipment Decontamination During the COVID-19 Pandemic: The Powered-Air Purifying Respirator Hood Optimal Decontaminant Distribution System.

Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association

Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…

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Negative / Null Result ReportOpen accessMedicine

The accuracy of recording malaria rapid diagnostic test (RDT) results in public health facilities in Benin; results from the MaCRA project.

Ahogni I, Avanon H, Hueha C et al. · 2026 · Malaria journal

Background Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs, concerns…

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Negative / Null Result ReportMedicine

Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study.

Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases

Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…

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