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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Radiation Therapy Dose Escalation Failed to Improve Local Control for Intermediate-Risk Rhabdomyosarcoma on ARST1431: A Report From the Children's Oncology Group.

Jackson CB, Xue W, Gupta AA et al. · 2025 · International journal of radiation oncology, biology, physics

Purpose To evaluate local failure (LF) rates for patients with intermediate-risk rhabdomyosarcoma treated on the Children's Oncology Group ARST1431 clinical trial, the first and largest international, phase 3 randomized study to use FOXO1…

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Negative / Null Result ReportOpen accessMedicine

Bertolotti joint-related cyst: illustrative case.

Chow WD, Spinner RJ, Amrami KK et al. · 2026 · Journal of neurosurgery. Case lessons

Background Bertolotti syndrome is an underrecognized cause of chronic low back pain. Back pain generated from Bertolotti syndrome is believed to result from altered weight dissipation mechanics and/or instability of the pseudoarticulation,…

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Negative / Null Result Report

Idiopathic Hyperhidrosis after Trauma: A Case Report

Pae Y, Park H, Lee H et al. · 2024 · Preprint

Abstract Background Hyperhidrosis is the secretion of excess sweat beyond what the body needs for homeostatic regulation. Secondary hyperhidrosis is usually related to an underlying cause, mostly a medical condition, or extrinsic factors…

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Negative / Null Result ReportOpen accessMedicine

Difficult to manage axial spondyloarthritis patients have high burden of pain-related comorbidities and adverse long-term outcome.

Bertsias A, Flouri I, Emmanouilidou E et al. · 2026 · Arthritis research & therapy

Background Difficult to manage (D2M) axial spondyloarthritis (axSpA) is an evolving clinical concept. We aimed to assess the prevalence, predictors and long-term outcomes of D2M axSpA. Methods Prospective single center cohort study of…

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Negative / Null Result ReportOpen accessMedicine

Failure to Improve Lumbar Lordosis After Single-Level TLIF for Degenerative Spondylolisthesis Does Not Impair Clinical Outcomes at 8.6 Years Postoperatively: A Prospective Cohort of 32 Patients.

Bošnjak K, Vengust R · 2025 · Journal of clinical medicine

Background : We aimed to analyze radiographic sagittal balance parameters in patients who underwent a TLIF procedure for single-level degenerative spondylolisthesis with a mean follow-up of 8.6 years and to determine whether lumbar…

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Negative / Null Result ReportMedicine

Partial versus whole tumor-volume irradiation in combination with immunotherapy: Comparable outcomes in immunosuppressed mouse models of oral squamous cell carcinoma.

Pisljar Z, Markelc B, Brezar SK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Radiotherapy is a standard therapy for oral squamous cell carcinoma (OSCC) with immunomodulatory potential. Due to high lymphocyte radiosensitivity, partial tumor-volume irradiation (pIR), targeting only part of the tumor, is being…

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Negative / Null Result ReportOpen accessMedicine

Effect of Small Molecules on Blastocyst Development and Outgrowth Establishment of Bovine Haploid Parthenogenetic Embryos.

Aguila L, Castillo R, Pérez-García F et al. · 2026 · Animals : an open access journal from MDPI

Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…

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Negative / Null Result ReportMedicine

Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial.

Calvani R, Giampaoli O, Marini F et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)

Background & aims Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long…

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Negative / Null Result ReportOpen accessMedicine

One size does not fit all: uncontrolled T2 inflammation on tezepelumab-a case series.

Tardif A, Boulay ME, Côté A et al. · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

BACKGROUND: Tezepelumab is the most recent human monoclonal antibody in the therapeutic arsenal of patients with severe uncontrolled asthma. It neutralizes thymic stromal lymphopoietin (TSLP). Phase 2 and phase 3 studies showed a…

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Negative / Null Result ReportMedicine

M2 macrophage-targeting peptide-modified liposomes enhance the uptake and antitumor efficacy of liposomal IFN-γ in mice with C26 colon carcinoma.

Kateh Shamshiri M, Vakili-Ghartavol R, Aiyelabegan HT et al. · 2025 · Cytokine

While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows…

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Negative / Null Result ReportOpen accessMedicine

Nintedanib Lacks Efficacy in a Spirometry-Confirmed and Bleomycin-Induced Mouse Model of Idiopathic Pulmonary Fibrosis.

Bousamaki J, Maciag G, Petersen AG et al. · 2026 · Basic & clinical pharmacology & toxicology

Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three…

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Negative / Null Result ReportOpen accessMedicine

Vitamin D Deficiency as a Risk Factor for Onset and Recurrence of Sudden Sensorineural Hearing Loss: A Prospective Cohort Study With Age-Specific Analysis.

Hui Q, Xiang T, Qinglan X et al. · 2026 · Food science & nutrition

The link between Vitamin D (Vit D) deficiency and sudden sensorineural hearing loss (SSNHL), especially regarding recurrence and age-related disparities, remains unclear. Recurrence and age-specific risks of SSNHL are under addressed,…

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Negative / Null Result ReportMedicine

Neighborhood bonding and bridging social capital, social activity participation, and short-term cognitive variability in later life.

Hyun J, Cerino ES, Katz MJ et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and…

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Negative / Null Result ReportOpen accessMedicine

Urodynamic findings and vibegron effects on neurogenic lower urinary tract dysfunction caused by human T-cell leukemia virus type I-associated myelopathy/tropical spastic paraparesis.

Kumekawa T, Akaihata H, Natsuya H et al. · 2024 · IJU case reports

Introduction Human T-cell lymphotropic virus type 1 infection can cause HTLV-1-associated myelopathy/tropical spastic paraparesis, characterized by spastic paralysis of both lower limbs. More than 90% of HAM/TSP patients show lower urinary…

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