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Browse the failure-mode index

19,847 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Visual processing and interference performance influences on knee angular impulse in ACLR individuals: a cognitive-biomechanical analysis of drop-jumps.

Santamaria-Guzman K, Holmes H, Kosek J et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Visual processing speed and cognitive interference control are critical for athletic performance and Anterior Cruciate Ligament (ACL) injury risk. However, how these cognitive functions relate to biomechanical performance…

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Negative / Null Result ReportOpen accessMedicine

A high-risk perioperative atrial fibrillation phenotype and early outcomes after isolated coronary artery bypass grafting.

Khalil E, Yüksel B · 2026 · Archives of medical sciences. Atherosclerotic diseases

Introduction Perioperative atrial fibrillation (POAF) remains the most common arrhythmic complication occurring in the setting of isolated coronary artery bypass grafting (CABG), and it is now being increasingly recognised as a marker of…

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Negative / Null Result ReportOpen accessMedicine

Association between Levels of Alcohol Use, Perceived HIV Risk, and Untreated HIV Among Persons at Alcohol-Serving Venues in Kenya and Uganda.

Beesiga B, Litunya J, Nakato JZ et al. · 2026 · AIDS and behavior

Alcohol-serving venues in East Africa are high-risk environments for HIV transmission but few studies in sub-Saharan Africa (SSA) have examined perceived HIV risk and sexual risk behaviors by alcohol use levels on a broader population of…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of Emotion-Focused Cognitive Behaviour Therapy on Emotional Hyporexia Among Adolescent Girls with Eating Problems: A Pilot Study.

Shinde SS, Naik NS, Adhyapak SU et al. · 2025 · Journal of pharmacy & bioallied sciences

Background Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for…

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Negative / Null Result ReportOpen accessMedicine

A Longitudinal Observational Study on Lactation-Associated Changes in Procalcitonin, Protein Carbonyl Content, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Dairy Cattle.

Sala G, Castelli M, Orsetti C et al. · 2025 · Veterinary sciences

Procalcitonin (PCT), protein carbonyl content (PCC), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been proposed as promising biomarkers for detecting diseases in cattle. Their concentrations could…

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Negative / Null Result ReportOpen accessMedicine

Influence of Coagulation Factor VIII on Ischemic Stroke.

Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia

Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…

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Negative / Null Result ReportOpen accessMedicine

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences

The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…

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Negative / Null Result ReportMedicine

Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.

Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers

Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…

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Negative / Null Result ReportOpen accessMedicine

Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.

Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…

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Negative / Null Result ReportMedicine

Assessment of the impact of microplastic ingestion in striped red mullets from an Eastern Mediterranean coastal area (Zakynthos Island, Ionian Sea).

Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research

Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.

Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports

More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…

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Negative / Null Result ReportOpen accessMedicine

Effect of Supplementation with Red Rooibos Tea on Body Composition, Metabolic Outcomes, and Movement in Ovariectomized Sprague-Dawley Rats.

Feld RS, Ianiero MA, Goncharow MK et al. · 2026 · Current developments in nutrition

Background Menopause is associated with increases in visceral adipose tissue, reductions in lean mass, and a reduced energy expenditure. The ovariectomized (OVX) rat model can be used to model these changes and to test potential…

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Negative / Null Result ReportOpen accessMedicine

Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis: An Assessor-Blinded Prospective Cohort Study.

Fukuda R, Hashimoto R, Pak K et al. · 2026 · Health science reports

Background and aims Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular…

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Negative / Null Result ReportMedicine

Melatonin Prevents Thymic Atrophy but Does Not Protect Against Disruption of T Cell Maturation Related to Cyclophosphamide Exposure.

Pimenta GF, Dourado TMH, de Souza KDB et al. · 2025 · Cell biochemistry and function

Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the thymic microenvironment and disrupts T cell maturation. The hormone melatonin displays…

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Negative / Null Result ReportMedicine

Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial.

Makhlin I, Demissei BG, D'Agostino R et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of…

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Negative / Null Result ReportOpen accessMedicine

Clinical efficacy of anti-amyloid antibodies in apolipoprotein E ε4 homozygotes: A Bayesian reanalysis of lecanemab and donanemab phase 3 results.

Teipel S, Tang Y, Khachaturian A · 2025 · Alzheimer's & dementia (New York, N. Y.)

Introduction We aimed to determine the clinical efficacy of treating apolipoprotein E (ApoE) ε4 homozygotes with recently approved anti-amyloid antibodies. Methods Data were derived from supplementary analyses in the regulatory studies…

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Negative / Null Result ReportOpen accessMedicine

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology

Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…

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Negative / Null Result ReportOpen accessMedicine

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…

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Negative / Null Result ReportMedicine

Lack of association between periodontitis and rheumatoid arthritis.

Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica

Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…

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