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Browse the failure-mode index

19,847 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

CX3CR1<sup>+</sup> synovial macrophages accumulate in the joint during experimental hemophilic arthropathy but are not required for acute synovitis.

Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH

Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…

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Negative / Null Result ReportMedicine

Self-Assessment Versus Peer Assessment of Oncology Communication Skills in Medical Students: A Video-Based Pilot Study.

Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education

Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…

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Negative / Null Result ReportMedicine

Transcutaneous vagus nerve stimulation for postoperative pain reduction in patients with childhood trauma: A randomized controlled pilot study.

Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research

Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…

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Negative / Null Result ReportMedicine

COP9 signalosome deneddylation activity is required for proliferation but not dedifferentiation of vascular smooth muscle cells in neointimal hyperplasia.

Giri S, Wang X · 2026 · American journal of physiology. Heart and circulatory physiology

Neointimal hyperplasia (NH) is a prominent pathological consequence following vascular injury and is driven in part by aberrant vascular smooth muscle cell (VSMC) proliferation. COP9 signalosome (CSN) subunit 5 (CSN5/JAB1/COPS5) is the…

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Negative / Null Result ReportMedicine

Effects of environmental enrichment on lymph node mitochondrial-redox status and immune response in adult male C57BL/6 mice.

de Sousa Fernandes MS, Kanashiro A, da Silva Fidélis DE et al. · 2026 · Scientific reports

Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox…

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Negative / Null Result ReportMedicine

JNK inhibition suppresses microglial NLRP3 activation and oxidative stress but unexpectedly worsens pain in diabetic neuropathy: insights from a combined in vitro and in vivo pharmacological study.

Ling L, Ali T, Li X et al. · 2026 · Neurochemistry international

Diabetic neuropathy (DN) is driven by neuroinflammation and oxidative stress, with c-Jun N-terminal kinase (JNK) as a key mediator; however, the effects of JNK inhibition on neuropathic pain remain unclear. Therefore, we investigated the…

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Negative / Null Result ReportMedicine

The Effect of Denture Cleansers on the Surface Roughness of Heat-Polymerized Denture Base Resins Polished by Three Different Techniques.

Chatzivasileiou K, Kamalakidis SN, Pissiotis AL et al. · 2026 · The International journal of prosthodontics

Purpose To evaluate the combined effect of different polishing protocols and different denture cleansers on the surface roughness of three heat-polymerized polymethyl methacrylate (PMMA) denture base materials. Materials and methods The…

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Negative / Null Result ReportMedicine

Effects of high-temperature treatment on in vitro protein digestibility and protein profiles of pea ingredients obtained from wet and dry fractionation.

Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry

Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…

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Negative / Null Result ReportMedicine

Mechanistic insights into the modification of peanut protein by novel radio frequency roasting: Revealing multi-scale protein conformational changes

Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.

Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…

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Negative / Null Result ReportMedicine

The effect of citalopram treatment on memory performance, mood state, catalase, BDNF, and MDA in REM sleep-deprived rats.

Elham Mahdavi, Ghorbani Yekta B, Fereshteh Atabi · 2026 · Cellular and molecular biology (Noisy-le-Grand, France)

Rapid-eye movement (REM) sleep is a critical stage of sleep that plays a pivotal role in memory formation, consolidation, and mood regulation. While REM sleep deprivation (REM SD) has been shown to impair cognitive and affective functions,…

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Negative / Null Result ReportMedicine

Expectations and tolerance of transcranial magnetic stimulation in patients with functional neurological disorder.

Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…

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Negative / Null Result ReportOpen accessMedicine

Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2.

Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences

Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…

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Negative / Null Result ReportMedicine

Comparison of the proteolysis and occurrence of a range of β-casomorphin peptides in commercial U.S. Cheddar cheeses manufactured from A1/A2 and A2/A2 β-casein milks.

Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science

Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…

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