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Browse the failure-mode index

19,847 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Safety Audit of a Large Language Model for Lay Self-Triage Using Japanese Symptom Vignettes: Persistent Red-Flag Under-Triage Despite Improved Reproducibility Under Near-Deterministic Decoding.

Harada Y · 2026 · Cureus

Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…

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Negative / Null Result ReportMedicine

The State of Surgery in Botswana, 2018 to 2022.

Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery

Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…

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Negative / Null Result ReportMedicine

Factors associated with failure to achieve Scoliosis Research Society-22r minimal clinically important difference despite achieving optimal global alignment in adult spinal deformity surgery.

Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…

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Negative / Null Result ReportMedicine

Quality assessment of radiographs through AI-driven feedback: A randomized comparative study on radiographer response in lateral knee radiographs.

Lysdahlgaard S, Jensen J, Pedersen MRV et al. · 2026 · Radiography (London, England : 1995)

Introduction High-quality radiographic positioning is essential for accurate diagnosis in knee imaging. Although artificial intelligence (AI) can assess image quality with high accuracy, its influence on radiographers' clinical…

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Negative / Null Result ReportMedicine

Retrospective Comparative Analysis of Diffusion Tensor and Constrained Spherical Deconvolution Tractography Models in a Clinical Neurosurgical Navigation Platform.

Watanabe A, Furukawa M, Hiruta R et al. · 2026 · Neurologia medico-chirurgica

Tractography is a technique for visualizing the trajectories of white matter pathways. The most widely used model, the diffusion tensor imaging, assumes a single fiber orientation within each voxel. In contrast, the constrained spherical…

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Negative / Null Result ReportMedicine

Enzalutamide Plus Metformin Versus Enzalutamide Alone in Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 2 Trial (SAKK 08/14).

Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology

Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…

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Negative / Null Result ReportMedicine

Modulation of neuroendocrine and autonomic responses to competitive stress by slow cortical potentials training in golfers: An exploratory randomized controlled trial.

Lizama E, Carcamo-Herrera B, López G et al. · 2026 · Psychoneuroendocrinology

Performance in precision sports such as golf depends on the athlete's ability to regulate psychophysiological responses under competitive pressure. Heart rate variability (HRV), cortisol, and DHEA provide complementary indices of autonomic…

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Negative / Null Result ReportOpen accessMedicine

Gene-specific response to muscle specific kinase agonist antibody in the treatment of congenital myasthenic syndromes.

Ho K, Adjei-Afriyie O, Carmona-Martinez R et al. · 2026 · Brain communications

Congenital myasthenic syndromes (CMS) are a group of rare disorders characterized by fatigable muscle weakness and caused by impaired neuromuscular junction (NMJ) function. CMS symptoms are highly variable, but it can be detrimental and…

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Negative / Null Result ReportMedicine

[Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report].

Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology

The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…

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Negative / Null Result ReportMedicine

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology

Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…

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Negative / Null Result ReportMedicine

Comparative performance of one-stage and two-stage deep learning models for instance segmentation of overhanging dental restorations on bitewing radiographs.

Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports

Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…

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Negative / Null Result ReportMedicine

The sonographic subpubic area is a predictor of anal incontinence after a first vaginal delivery: A prospective cohort study.

Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…

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Negative / Null Result ReportMedicine

Hand therapy or not following collagenase treatment for Dupuytren's disease? A randomized controlled trial.

Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists

Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…

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Negative / Null Result ReportMedicine

Psychometric Evaluation and Discriminative Validity of the Short-Form Brief Pain Inventory Across Nociceptive, Neuropathic, and Nociplastic Pain Mechanisms.

Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain

The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…

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Negative / Null Result ReportMedicine

Mature oocyte yield in patients with diminished ovarian reserve treated with luteal estradiol priming with or without GnRH antagonist.

Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology

Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…

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Negative / Null Result ReportMedicine

The Effect of PTFE Coating and PTFE Tape Wrapping Abutment Screw After Cyclic Loading: An In Vitro Study.

Kongkhuntian P, Aunmeungtong W, Khongkhunthian P · 2026 · Clinical implant dentistry and related research

Objective This study aimed to compare the effect of PTFE tape wrapping and PTFE-coated titanium alloy screws on the removal torque after cyclic loading and on preload values under repetitive tightening. Methods A total of 60 titanium…

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Negative / Null Result ReportMedicine

Reduction in copper and pesticide levels in grape musts: A new asset for the implementation of bioprotection in oenology.

Tournu E, Tourdot-Maréchal R, Coelho C · 2026 · International journal of food microbiology

Phytosanitary and copper treatments in viticulture are essential to protect vines against biotic and abiotic stresses. However, residues from these treatments can persist in grape musts and wines, potentially raising risks to consumer…

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Negative / Null Result ReportMedicine

Personalized Treatment Selection for Digital Eating Disorder Interventions: A Proof-of-Concept for the Personalized Advantage Index.

McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders

Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…

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Negative / Null Result ReportMedicine

Can biochar and late-season nitrogen fertilization overcome the sulfur-containing amino acid deficiency and improve oil stability in soybean seeds?

Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science

Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…

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Negative / Null Result ReportMedicine

A novel face scale and National Early Warning Score 2 prediction model to assess deteriorating patients in hospital wards: A quick visual early warning score study.

Wall A, Fisher JA, Watkinson EK et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Early warning scores like the National Early Warning Score 2 (NEWS2) identify patient deterioration but do not incorporate clinician-intuitive assessment. Previous research suggests facial expressions can be critical indicators…

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Negative / Null Result ReportMedicine

Assessment of Seed Treatments for Management of Pathogens Causing Seed Rot, Seedling Damping-off, and Seedling Root Rot in Alfalfa ( Medicago sativa ).

Larsen LJ, Dornbusch MR, Hines-Snider C et al. · 2026 · Plant disease

Seed rot and damping-off of alfalfa ( Medicago sativa L.) is caused by a soilborne disease complex resulting in thin initial stands of plants with continuing damage during wet soil conditions decreasing forage yields and winter survival.…

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Negative / Null Result ReportMedicine

Communicating Time-to-Event Treatment Effects in Randomized Trials: A Randomized Experiment among General Practitioners.

Giese H, Gaissmaier W, Kuss O et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundTime-to-event outcomes from randomized controlled trials (RCTs) are often communicated without clearly conveying how treatment effects evolve over time. This can limit clinicians' ability to interpret results and support patient…

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