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Browse the failure-mode index

20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Endovascular thrombectomy in addition to intravenous thrombolysis versus intravenous thrombolysis alone in medium distal vessel occlusions: Results from the SITS International Stroke Treatment Register.

Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society

Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…

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Negative / Null Result ReportMedicine

Surgical nodal staging in rhabdomyosarcoma of the bladder and/or prostate with or without nodal or metastatic spread. A report from the European Paediatric Soft-Tissue Sarcoma Study Group (EpSSG).

Smeulders N, Gaze MN, Guérin F et al. · 2026 · Journal of pediatric surgery

Background Risk stratification of rhabdomyosarcoma (RMS) requires accurate staging, with histological nodal assessment being of critical importance for specific tumour sites. This report explores the value of surgical nodal staging in…

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Negative / Null Result ReportOpen accessMedicine

Residual Wrist Pain and Cyst Recurrence Following Removal of Dorsal Ganglion With and Without Posterior Interosseous Nerve Neurectomy.

Furlong CT, Stanton HL, Yin R et al. · 2026 · Journal of hand surgery global online

Purpose Pain from dorsal wrist ganglion cysts may result from irritation of the terminal branch of the posterior interosseous nerve. Excision of this branch is often used to treat wrist pain from various etiologies, including recurrent…

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Negative / Null Result ReportMedicine

A Fine Balance: Anticoagulation for Non-Valvular Atrial Fibrillation After Cerebral Amyloid Angiopathy-Related Intracranial Haemorrhage.

Turner D, Kamadasala K, McGarity B · 2025 · Heart, lung & circulation

The management of anticoagulation in patients with non-valvular atrial fibrillation at high risk of bleeding complications can be challenging. One such group is elderly patients with previous intracranial haemorrhage secondary to cerebral…

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Negative / Null Result ReportMedicine

Atrial shunt therapy for heart failure: an update review.

Giorgi J, Flores-Bravo Y, Dandamudi M et al. · 2025 · Heart failure reviews

Interatrial shunt devices (IASDs) and implant-free strategies have emerged as novel approaches for heart failure (HF) management by mechanically unloading the left atrium (LA) to reduce left atrial pressure (LAP), a key driver of pulmonary…

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Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

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Negative / Null Result ReportMedicine

PACAP and migraine.

Diener HC · 2025 · Brain : a journal of neurology

A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…

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Negative / Null Result ReportOpen accessMedicine

Nonpigmented Adenoid Subtype of Basal Cell Carcinoma: A Case Report.

Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology

Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…

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Negative / Null Result ReportOpen accessMedicine

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology

Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…

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Negative / Null Result ReportOpen accessMedicine

Revisiting Janus Kinase Inhibitors in Hospitalized COVID-19: Evidence for Baricitinib's Superiority and the Absence of a Class Effect.

Gu L, Lin J, Yue J et al. · 2025 · Journal of inflammation research

Janus kinase (JAK) inhibitors, developed for autoimmune diseases, have been repurposed as potential therapies for severe COVID-19. Growing evidence indicates that their clinical utility is heterogeneous and cannot be generalized as a class…

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Negative / Null Result ReportMedicine

Use of a Personalised Early Warning Decision Support System for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the "Predict & Prevent" Phase III Trial.

Gkini E, Mehta RL, Tearne S et al. · 2025 · COPD

Rationale The Predict&Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDPredict™. Methods Adults with ≥1 AECOPD were randomly assigned in a 1:1 ratio…

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Negative / Null Result Report

Lack of evidence for cargo release of CD63-EVs into recipient cells

Askarian-Amiri S, Weissenhorn W, Sadoul R et al. · 2025 · Preprint

Extracellular vesicles (EVs), including exosomes, are widely believed to mediate intercellular communication by delivering molecular cargo to recipient cells. However, the efficiency and mechanisms of such cargo delivery remain unclear. In…

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Negative / Null Result ReportMedicine

Machine Learning and Urinary Incontinence in Prostate Cancer: A Generalized Additive Model of Physical Activity and Recovery Patterns.

Manolitsis I, Feretzakis G, Tzelves L et al. · 2025 · Studies in health technology and informatics

The ASCAPE project aims to improve the health-related quality of life of prostate cancer patients using artificial intelligence-driven solutions. This study tries to unravel the complex relationships between patient data variables and…

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Negative / Null Result ReportMedicine

Long-term Results from the LEA Randomized Trial: Extended Versus Standard Lymph Node Dissection in Patients with Bladder Cancer Undergoing Radical Cystectomy.

Heck MM, Lehmann J, Amiel T et al. · 2025 · European urology

The extent of lymph node dissection (LND) at the time of radical cystectomy (RC) for bladder cancer (BC) may affect oncologic outcomes. We present updated long-term data from a prospective, multicenter, phase 3 trial involving patients…

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Negative / Null Result ReportMedicine

[Hortitherapy and well-being in day care centres].

Zivkovic Habibi L, Zaibat M, Frenkiel J et al. · 2025 · Soins. Gerontologie

Day care centers are medical and social facilities that provide day care for people over 60 with Alzheimer's or related diseases. The main aim of the study presented here was to assess the impact of horticultural therapy sessions on the…

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Negative / Null Result ReportMedicine

Combination of short pulse and smooth modality of Er: YAG laser versus short pulse alone in treatment of striae distensae: a split-lesion study.

Sadeghinia A, Emadi SN, Jamshidi S et al. · 2025 · Lasers in medical science

Background Despite extensive research, there is still no consensus on the optimal treatment for Striae distensae (SD). Aim To evaluate the efficacy of ablative (short pulse (SP) mode) versus combined ablative and non-ablative (short pulse…

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