20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Gandhi A, Parhizgar A · 2025 · Frontiers in endocrinology
Initially developed for type 2 diabetes and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now emerging as promising candidates for modifying the course of neurodegenerative diseases. This potential stems from the…
View details →Aragón-Sánchez J, Víquez-Molina G, López-Valverde ME et al. · 2023 · Diabetic medicine : a journal of the British Diabetic Association
Aims We hypothesize that microbiology- and pathology-confirmed positive bone margins after the resection of diabetes-related foot osteomyelitis are associated with worse outcomes. Methods We conducted a prospective study consisting of a…
View details →Ahmed N, Russo L, Kuo YH · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives To compare levetiracetam and phenytoin as prophylaxis for the short-term development of status epilepticus (SE) during care of pediatric patients with acute severe traumatic brain injury (TBI). Design Nonprespecified secondary…
View details →Shefner JM, Cudkowicz ME, Genge A et al. · 2025 · JAMA neurology
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect of reldesemtiv vs…
View details →Apivatgaroon A, Sukkarnkosol S, Pukrittayakamee NC et al. · 2025 · JSES international
Background Suspension stabilization is a commonly used surgical method for acute acromioclavicular (AC) joint dislocation. However, a failure rate of around 26% caused various emerging surgical techniques and recommendations. We aimed to…
View details →Rannikko EH, Pajula S, Suominen SH et al. · 2025 · Plastic and reconstructive surgery
Background Breast cancer-related lymphedema is a common complication lacking medical treatment. Lymfactin is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth…
View details →Kim S, Shin MJ, Krauss RM · 2025 · Current atherosclerosis reports
Purpose of review This paper reviews the effects of major macronutrients and specific dietary interventions on atherogenic dyslipidemia, a common trait characterized by increased concentrations of triglyceride-rich and small, dense LDL…
View details →Idani D, Mashhadi SM, Babaei H et al. · 2024 · Preprint
Purpose: To evaluate vascular changes in patients with diabetic macular ischemia (DMI) after systemic oxygen therapy using Optical coherence tomography angiography (OCTA). Methods: : This interventional before-after study included 26 eyes…
View details →Cavalcante FP, Cardoso A, Antonini M et al. · 2025 · Translational breast cancer research : a journal focusing on translational research in breast cancer
Background Neoadjuvant chemotherapy (NAC) is widely accepted as standard treatment in breast cancer, particularly in cases of tumors with aggressive biology. NAC has increased the rates of breast-conserving surgery (BCS) and the conversion…
View details →Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung
Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…
View details →Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…
View details →Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine
Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…
View details →Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy
Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…
View details →Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association
Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…
View details →Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry
Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…
View details →Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine
Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…
View details →O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology
Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…
View details →Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin
Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…
View details →Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint
Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…
View details →Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine
Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…
View details →Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills
In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…
View details →Song M, Launder NH, Phutane VH et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
ObjectiveMajor depressive disorder (MDD) is a highly prevalent debilitating mental health disorder with a lifetime risk of 11-15% in Australia. The most effective treatment for severe depression is electroconvulsive therapy (ECT), but it…
View details →Judith PJ, Maureen B, Mélanie P et al. · 2024 · Health science reports
Background In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. Patients/methods A…
View details →Thach B, Wang Y, Heng S et al. · 2024 · Placenta
Introduction The syncytiotrophoblast (STB) of the human placenta facilitates vital maternal-fetal communication and is maintained by fusion (syncytialization) of cytotrophoblasts. Serine protease HtrA4 (high temperature requirement factor…
View details →Li M, Chen H · 2025 · BMC cardiovascular disorders
Background Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative…
View details →Valle AEPd, Hare M, Karley A et al. · 2026 · Preprint
Abstract Systems approaches are becoming widely recognised for their potential to address the complexity of food systems’ challenges and lead needed transformations. However, there is limited attention on how systems thinking is being…
View details →Zahl-Olsen R, Gausel N, Håland ÅT et al. · 2026 · Journal of clinical psychology
Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale-reliability to…
View details →Ito R, Okanoya K · 2026 · Preprint
Octave equivalence—the tendency to perceive tones separated by a 2:1 frequency ratio as perceptually similar—is a fundamental feature of human pitch perception and a key component of musical pitch organization. Evidence for octave…
View details →Cassart T, Kyranides MN, Vandevelde S et al. · 2025 · Personality disorders
This study examined the existence and validity of variants of callous-unemotional (CU) traits. Data were available for 309 detained boys ( M age = 16.96) who completed self-reports, experimental tasks, and were administered a diagnostic…
View details →Sitton MJ, McDonald R, Rosenfield D et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)
Emotional support from a caregiver is theorized to benefit adolescents after sexual abuse, yet the empirical evidence for this is inconsistent. The present study examines the cross-sectional relation between caregiver emotional support and…
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