19,843 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Gusdorf J, Earle WB, Li S et al. · 2026 · The American journal of cardiology
Atherosclerotic renal artery stenosis (RAS) affects nearly 7% of adults over age 65 and is associated with increased cardiovascular and renal morbidity. Although early observational studies suggested benefit from renal artery stenting,…
View details →Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology
Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…
View details →Xue J, Ye J, Han P et al. · 2025 · The journal of gene medicine
Background Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored the role of…
View details →Diener HC · 2025 · Brain : a journal of neurology
A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…
View details →Park SK, Chung Y, Oh CM et al. · 2026 · Global heart
Background There have been inconsistent findings regarding the effects of high sodium intake on coronary artery disease (CAD). This study therefore aimed to investigate the relationship between sodium intake and the coronary artery calcium…
View details →Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology
Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…
View details →Spyropoulou N, Diamantopoulou S, Patrinos S et al. · 2025 · Preprint
OBJECTIVE: The purpose of this study was to examine and compare the clinical be-havior of indirect onlays/overlays made of lithium disilicate and composite resin and to investigate risk factors associated with restorations failures.…
View details →Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology
Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…
View details →Gu L, Lin J, Yue J et al. · 2025 · Journal of inflammation research
Janus kinase (JAK) inhibitors, developed for autoimmune diseases, have been repurposed as potential therapies for severe COVID-19. Growing evidence indicates that their clinical utility is heterogeneous and cannot be generalized as a class…
View details →Jain H, Zakieh O, Chanbour H et al. · 2025 · Clinical neurology and neurosurgery
Introduction Coronal malalignment (CM) remains an understudied and challenging problem in adult spinal deformity (ASD) surgery, and the impact of the lumbosacral fractional curve (LSF) correction on postoperative outcomes remains poorly…
View details →Gkini E, Mehta RL, Tearne S et al. · 2025 · COPD
Rationale The Predict&Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDPredict™. Methods Adults with ≥1 AECOPD were randomly assigned in a 1:1 ratio…
View details →Askarian-Amiri S, Weissenhorn W, Sadoul R et al. · 2025 · Preprint
Extracellular vesicles (EVs), including exosomes, are widely believed to mediate intercellular communication by delivering molecular cargo to recipient cells. However, the efficiency and mechanisms of such cargo delivery remain unclear. In…
View details →Manolitsis I, Feretzakis G, Tzelves L et al. · 2025 · Studies in health technology and informatics
The ASCAPE project aims to improve the health-related quality of life of prostate cancer patients using artificial intelligence-driven solutions. This study tries to unravel the complex relationships between patient data variables and…
View details →Heck MM, Lehmann J, Amiel T et al. · 2025 · European urology
The extent of lymph node dissection (LND) at the time of radical cystectomy (RC) for bladder cancer (BC) may affect oncologic outcomes. We present updated long-term data from a prospective, multicenter, phase 3 trial involving patients…
View details →Helk O, Wagner L, Sengölge G et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives: Kidney injury is a frequent complication of multiple myeloma (MM) and monoclonal gammopathies. Podocyte stress markers, such as urinary nephrin and podocin, have been studied in other renal diseases but their utility…
View details →Zivkovic Habibi L, Zaibat M, Frenkiel J et al. · 2025 · Soins. Gerontologie
Day care centers are medical and social facilities that provide day care for people over 60 with Alzheimer's or related diseases. The main aim of the study presented here was to assess the impact of horticultural therapy sessions on the…
View details →Osama G, Elhilali H, Salah M et al. · 2025 · Strabismus
Purpose To compare the efficacy of two methods: first, bilateral symmetric anteriorization of the inferior oblique muscle and second: combined resection and anteriorization of the inferior oblique (IO) muscle for asymmetric dissociated…
View details →Sadeghinia A, Emadi SN, Jamshidi S et al. · 2025 · Lasers in medical science
Background Despite extensive research, there is still no consensus on the optimal treatment for Striae distensae (SD). Aim To evaluate the efficacy of ablative (short pulse (SP) mode) versus combined ablative and non-ablative (short pulse…
View details →Dubin A · 2025 · Annals of intensive care
Background Fluids are a key component of shock resuscitation. Nevertheless, their microvascular effects are complex. In fluid responsive patients, fluids may increase tissue perfusion because of the increase in cardiac output. Since shock…
View details →Wregg JF, Hofer A, Gruber-Wackernagel A et al. · 2026 · Experimental dermatology
Water-filtered infrared-A (wIRA) has been proposed to enhance tissue perfusion and modulate fibrosis, but clinical evidence in morphea (localised scleroderma) is limited. We conducted a prospective, intra-individual pilot split-study in 10…
View details →Cradeur A, Abshire M, Schichtel M et al. · 2025 · Preprint
Objectives: This prospective study aimed to assess noise levels in otolaryngology operating rooms (OR), explore noise variation across subspecialties, and examine the correlation between noise, verbal communication, and surgery complexity.…
View details →Acikgoz NB, Toplu-Hocaoglu A, Yildirim BA et al. · 2026 · Epilepsy research
Purpose The ketogenic diet has long been used in epilepsy treatment, particularly in drug-resistant cases, but its efficacy in idiopathic generalized epilepsy, including absence epilepsy, remains less studied. This study aimed to evaluate…
View details →SAW YH, CHAI HI, YAHYA NA et al. · 2026 · Preprint
Abstract Background Energy drinks are widely consumed acidic beverages that may compromise the longevity of resin composite restorations. However, limited evidence exists regarding the use of swept-source optical coherence tomography…
View details →Pettenuzzo T, Sella N, Zarantonello F et al. · 2026 · Preprint
Abstract Background. High-flow nasal cannula (HFNC) is a promising respiratory support modality that improves oxygenation, alveolar recruitment, and comfort while reducing dead space compared to conventional oxygen therapy. Recently, a…
View details →Dağlı E, Çapar ÖF, Sert S · 2026 · Scientific reports
This study examines the effects of freeze-thaw (F-T) cycles on the unconfined compressive strength (UCS) of untreated and stabilized soils using fly ash, lime, and lime-fly ash mixtures (30% FA, 5% L, and 30% FA + 5% L). Specimens were…
View details →Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine
Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…
View details →Liu L, Shen Y, Yang S et al. · 2026 · Journal of biotechnology
As an enzyme cofactor, antioxidant, and stabilizer of cellular structures, Mn²⁺is essential for microbial growth, metabolism, and environmental adaptation. In this work, the impact of varying Mn²⁺ levels on caproic acid formation and…
View details →Yilmaz AB, Karimzada K, Ozercan AY et al. · 2025 · Journal of robotic surgery
To evaluate the predictive value of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) score, Comorbidity Score for Robotic Surgery (CRS) and Charlson Comorbidity Index (CCI) in relation to postoperative complications in…
View details →Marshall MJ, Peck K, Hunter R et al. · 2024 · Behavioral sciences (Basel, Switzerland)
Eysenck's biopsychological model of stress posits that the extraversion-introversion distinction is associated with different thresholds of arousal, which in turn moderate the stress response. Although higher thresholds of activation have…
View details →Gow J, Roofeh D · 2025 · Preprint
Abstract Background: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features…
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