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Browse the failure-mode index

20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Virtual embodiment of civic heroes preserves the conflict associated with anti-mafia intentions and enhances physiological discomfort in response to mafia-related crime

Placidi V, Lisi MP, Vabba A et al. · 2025 · Preprint

Although Mafia-type criminal organizations (MCOs) exert severe societal harm, evidence-based interventions fostering anti-mafia motives remain scarce. We investigated whether embodying virtual heroic characters enhances opposition to MCOs.…

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Negative / Null Result ReportMedicine

Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial.

Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia

Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of Liposomal Bupivacaine for Anterior Quadratus Lumborum Block in Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.

Zhang YH, Xiao Y, Li YT et al. · 2026 · Drug design, development and therapy

Background Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine…

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Negative / Null Result ReportMedicine

Association Between Early Initiation of Electroconvulsive Therapy and Length of Stay in Acute Psychiatric Inpatients: A Retrospective Cohort Study in Taiwan.

Su PL, Ho MF, Liu PH et al. · 2026 · The journal of ECT

Objectives Electroconvulsive therapy (ECT) provides rapid relief for severe psychiatric disorders, but its impact on hospital length of stay (LOS) remains unclear in Asian settings. We hypothesized that early ECT (≤7 d after admission)…

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Negative / Null Result ReportMedicine

Plant functional diversity does not dilute virus infection, but community virus prevalence positively correlates with net C3 grass production

Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.

Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…

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Negative / Null Result ReportMedicine

A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.

Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…

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Negative / Null Result ReportMedicine

Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012-2016).

Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia

Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…

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Negative / Null Result ReportMedicine

Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial.

Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…

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Negative / Null Result ReportMedicine

Clinical impact of enhanced recovery after spinal surgery protocols on one-level lumbar arthrodesis: results from a single-center randomized controlled trial.

Kashtiara A, Pauptit J, Thijs D et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Objectives Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols may reduce pain, hospital length of…

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Negative / Null Result ReportMedicine

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial.

Tavolinejad H, Bozorgi A, Emkanjoo Z et al. · 2025 · Journal of the American College of Cardiology

Background Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear.…

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Negative / Null Result ReportMedicine

Effects of routine invasive management on reinfarction risk in older adults with frailty and non-ST-segment elevation myocardial infarction: a subanalysis of a randomised clinical trial.

Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)

Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…

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Negative / Null Result Report

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study

Qiao W, Liu L, Zhang X et al. · 2024 · Preprint

Abstract Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high…

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Negative / Null Result ReportOpen accessMedicine

Virtual Nursing for the Care of Hospitalized Patients.

Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open

Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…

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Negative / Null Result ReportMedicine

Managing visceral leishmaniasis-associated hemophagocytic lymphohistiocytosis in pediatric patients: Clinical insights and treatment strategies.

Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…

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Negative / Null Result ReportMedicine

Extended use of point-of-care technology by acute community nurses during in-home assessment of older adults with potential acute respiratory conditions: a parallel-group, open-label, randomised controlled trial.

Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity

Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…

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Negative / Null Result ReportOpen accessMedicine

C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion.

Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus

Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…

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