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Browse the failure-mode index

19,843 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Use of blood micro-samples in forensic thanatology.

Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international

In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…

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Negative / Null Result ReportOpen accessMedicine

Impact of Emergency Surgery for Acute Type A Aortic Dissection on Postoperative Renal Function in Patients With Autosomal Dominant Polycystic Kidney Disease.

Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports

Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…

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Negative / Null Result ReportMedicine

Effects of percussive massage vs. foam rolling on hamstring function: a comparative study using shear wave elastography, tensiomyography, and MyotonPro.

Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation

Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…

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Negative / Null Result ReportMedicine

Core Temperature Estimation Using Wearable Earbud-Type Thermometer and Machine Learning During Light-Intensity Cycling Under Varying Indoor Ambient Temperatures.

Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports

Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…

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Negative / Null Result ReportMedicine

Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3.

Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism

Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…

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Negative / Null Result ReportMedicine

The Association of the Social Deprivation Index With the Development of Peripheral Arterial Disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

Brandon AS, Murphy BS, Nam Y et al. · 2026 · The American journal of cardiology

Peripheral arterial disease (PAD) has many established risk factors, but social determinants of health (SDoH) are increasingly recognized as a cardiovascular disease risk factor. The multi-ethnic study of atherosclerosis (MESA) cohort was…

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Negative / Null Result ReportMedicine

Acute Beetroot Juice Supplementation and Repeated Maximal Effort in Elite Swimmers: A Randomized Double-Blind Study.

Arnaoutis G, Vallas G, Toubekis AG et al. · 2026 · International journal of sport nutrition and exercise metabolism

Beetroot juice (BRJ) has been proposed as an ergogenic aid due to its high nitrate content, yet evidence from field-based studies in elite swimmers remains limited. This study investigated the acute effects of concentrated BRJ ingestion on…

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Negative / Null Result ReportMedicine

Evaluation of anti-hyperglycemic, hepatic gene-modulatory and tissue-protective effects of curcumin, curcumin-loaded zeolitic imidazolate framework-8, and metformin in zebrafish (Danio rerio).

Moghadam H, Sourinejad I, Kalbassi MR et al. · 2026 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

Widely recognized for its translational relevance, the zebrafish (Danio rerio) is a validated model for evaluating antihyperglycemic agents. Nanocapsulation technologies have been proposed to enhance the bioefficacy of natural compounds…

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Negative / Null Result Report

Fracture Resistance and Failure Patterns of Endodontically Treated Maxillary Incisors Restored Using Different Coronal Strategies After Thermomechanical Aging: An In Vitro Study

Chew KH, Michael MC, Ghani NRNA · 2026 · Preprint

Abstract Objectives To investigate the influence of different coronal restorative strategies on the fracture resistance and failure patterns of endodontically treated maxillary incisors following thermomechanical aging. Materials and…

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Negative / Null Result Report

Progressive Strength Training Counteracts Frailty but Does not Improve Short-Term Autonomic Compensatory Responses During Active Standing Orthostatic Stress

Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint

Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…

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Negative / Null Result ReportMedicine

Impact of Probiotic-Adjunctive Vonoprazan-Amoxicillin Dual Therapy on Gut Microbiota and Clinical Symptoms in Helicobacter pylori Eradication.

Yang Y, Lan C, Jiang Z · 2026 · Tissue engineering and regenerative medicine

Background This study evaluates the impact of Bacillus subtilis dual-strain enteric-coated capsules combined with vonoprazan-amoxicillin (VA) therapy on Helicobacter pylori (Hp) eradication rates, gastrointestinal symptoms, adverse events…

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Negative / Null Result ReportMedicine

In Vivo Evaluation of Preconditioned Adipose-Derived Stromal Cells Reveals Limited Impact on Vascular and ECM Remodeling in Polymer Scaffolds.

Pinheiro-Machado E, Kuiper T, Huurman RH et al. · 2026 · Journal of biomedical materials research. Part B, Applied biomaterials

Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood…

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Negative / Null Result ReportMedicine

The Impact of Blood Pressure Targets on Hemodynamics in Patients With Cardiogenic shock Caused by Infarction-Related Out-of-Hospital Cardiac Arrest: A Substudy of the BOX-trial.

Ten Berg S, Beske RP, Grand J et al. · 2026 · European heart journal. Acute cardiovascular care

Background Noradrenaline is frequently used to increase mean arterial pressure (MAP) in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest (OHCA-AMICS). This Blood pressure and Oxygenation-Targets…

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