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Browse the failure-mode index

19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Prenatal representations of women with minor depressive symptoms: a randomised controlled trial of an interactive ultrasound intervention.

Lindstedt J, Ekholm E, Pulliainen H et al. · 2026 · Journal of reproductive and infant psychology

Background Maternal depressive symptoms are common during pregnancy and may negatively impact the mother-infant relationship, particularly the development of maternal prenatal representations. This study used a randomised controlled trial…

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Negative / Null Result ReportMedicine

Nivolumab plus chemoradiotherapy followed by nivolumab with or without ipilimumab for untreated locally advanced stage III NSCLC: a randomized phase 3 trial.

Peters S, Tan DSW, Gerber DE et al. · 2026 · Nature cancer

Over 50% of persons with unresectable stage III non-small cell lung cancer (NSCLC) treated with standard-of-care concurrent chemoradiotherapy (CCRT) and durvalumab consolidation progress or die within 18 months. Here adults with untreated,…

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Negative / Null Result ReportMedicine

Predicting parents' HPV vaccination intentions and behaviors across countries and time.

Schulz JV, Doerflinger JT, Behm C et al. · 2026 · Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Objective This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating…

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Negative / Null Result ReportOpen accessMedicine

Combined Detection of Preoperative Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Carcinoma: A Retrospective Multicenter Cohort Study.

Yang Y, He Y, Lin B et al. · 2026 · Health care science

Background The aim of this study was to investigate the clinical value of combined detection of preoperative serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) for diagnosing medullary thyroid carcinoma (MTC), as well as predicting…

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Negative / Null Result ReportMedicine

A novel approach to the clinical assessment of juvenile fibromyalgia syndrome: the Juvenile Fibromyalgia Multidimensional Assessment Report.

Drago E, Lavarello C, Alongi A et al. · 2026 · Clinical and experimental rheumatology

Objectives Development and psychometric evaluation of a disease-specific, paediatric-targeted multidimensional questionnaire for the assessment of juvenile fibromyalgia syndrome (JFS) in routine clinical practice. Methods The Juvenile…

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Negative / Null Result ReportMedicine

The effect of mitomycin-C on 3 snip punctoplasty.

Dertsiz Kozan B, Utlu B · 2026 · International ophthalmology

Purpose To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora. Material and methods Demographic characteristics, follow-up period,…

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Negative / Null Result ReportMedicine

Patient-Level Modeling of Ménière's Disease vs. Vestibular Migraine: Performance of Speech Discrimination and Caloric-vHIT Dissociation.

Pérez-Fernández N, Arbizu L · 2026 · Journal of clinical medicine

Background : Differentiating Ménière's disease (MD) from vestibular migraine (VM) remains difficult because current diagnostic frameworks are predominantly clinical and incorporate pure-tone thresholds, risking incorporation bias. We asked…

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Negative / Null Result ReportMedicine

Effectiveness and safety of treatment for heterozygous familial hypercholesterolaemia and multifactorial dyslipidaemia in children: an overview of systematic reviews.

Le Thi TG, Geist M, Novosad Y et al. · 2026 · European journal of preventive cardiology

Aims This overview of systematic reviews (SRs) summarizes evidence on effectiveness and safety of treatment for paediatric heterozygous familial hypercholesterolaemia (heFH) and multifactorial dyslipidaemia (MFD). Methods and results…

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Negative / Null Result ReportMedicine

Clinical and microbiological characteristics of multidrug-resistant acute bacterial endophthalmitis after cataract surgery. Endophthalmitis Management Study Report # 8.

Das T, Belenje A, Joseph J et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis. Methods Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical…

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Negative / Null Result ReportMedicine

Supervised exercise and pelvic floor muscle training eases current pelvic and genital pain but not worst pelvic and genital pain in women with endometriosis: a randomised trial.

Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy

Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…

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Negative / Null Result Report

Perineural Invasion as a High-Risk Feature Is Not a Predictive Biomarker for Postoperative Adjuvant Radiotherapy in Stage II Low Rectal Cancer: A Retrospective Analysis of a Real-World Cohort

Li X, Yan M, Li T et al. · 2025 · Preprint

Abstract Background Perineural invasion (PNI), though reported with varying incidence in rectal cancer, is a recognized marker of adverse prognosis. While postoperative adjuvant radiotherapy is a cornerstone of multidisciplinary management…

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Negative / Null Result ReportMedicine

Utility of RB1 immunohistochemistry for prognostic subtyping of pulmonary large cell neuroendocrine carcinoma.

Minkley M, Ravasia K, Nghiem T et al. · 2026 · Virchows Archiv : an international journal of pathology

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an aggressive and molecularly heterogenous cancer with poorly defined treatment strategies. We aimed to (i) assess whether RB1 immunohistochemistry alone can prognostically stratify…

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Negative / Null Result ReportMedicine

Macular Optical Coherence Tomography Angiography Biomarkers Predict Regional Retinal Nonperfusion Patterns on Ultrawidefield Angiography in Diabetes.

Kakihara S, Busza AM, Duffy BV et al. · 2026 · American journal of ophthalmology

Objective To determine whether foveal avascular zone (FAZ) enlargement and geometric perfusion deficits in the deep capillary plexus (GPDd) are independently associated with retinal nonperfusion in different regions of ultrawidefield…

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Negative / Null Result Report

IMPROVING HAND HYGIENE IN CRUISE SHIP: AN INTERVENTION STUDY

Bansaghi S, Klein J · 2026 · Preprint

Background Cruise ships are relatively small, crowded spaces where many people travel in a new environment, making infection control especially important. Proper hand hygiene is the first line of defense against the spread of infection.…

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Negative / Null Result ReportMedicine

Toward Earlier Bedtimes: Randomized Trial of Multi-Method Interventions in a Community Cohort of Adolescents.

Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…

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Negative / Null Result ReportMedicine

Clinical evaluation of obturator nerve involvement following a supra-inguinal fascia iliaca compartment block: A randomized, double-blind trial.

Miao Y, Zhang H, Wu J et al. · 2026 · Journal of clinical anesthesia

Background Clinical evidence on obturator nerve involvement after supra-inguinal fascia iliaca compartment block (SFICB) is limited. This study aimed to investigate whether a 40-mL SFICB reliably anesthetizes the obturator nerve and…

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Negative / Null Result ReportMedicine

Treatment outcomes of Mycobacterium simiae pulmonary disease: a retrospective multicenter cohort study.

Najjar-Debbiny R, Cohen R, Arbel A et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

BACKGROUND: Mycobacterium simiae is an emerging cause of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the Middle East, yet treatment outcomes remain unclear. We aimed to evaluate clinical and microbiologic outcomes of M.…

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Negative / Null Result ReportMedicine

Minimum 10-year Results of Cementing a Polyethylene Liner Into an Acetabular Cup With a Deficient Locking Mechanism: Is It a Reliable Option?

Rhyu KH, Cho YJ, Chun YS et al. · 2026 · Clinical orthopaedics and related research

Background Cementing a new liner into a well-fixed acetabular cup with a deficient locking mechanism has been reported as a viable option, but concerns remain regarding complications such as dislocation and late loosening.…

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