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19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The effect of clinical bibliotherapy on self-esteem, hope and depressive symptoms among adolescents living with sickle cell disorder in Ibadan, Nigeria: a non-randomized controlled pilot study.

Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine

Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…

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Negative / Null Result ReportMedicine

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.

Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one

Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…

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Negative / Null Result ReportMedicine

Anti-complement and anticoagulant activities from the salivary glands and gut of Ctenocephalides felis felis (Siphonaptera: Pulicidae) in wild and domestic Carnivora hosts.

Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology

Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…

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Negative / Null Result ReportMedicine

High-Frequency Gastric Electrical Stimulation Selectively Remodels Nitrergic Neurons in the Gastric Antrum of Healthy Beagles.

Huang, Fu, Yang et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

The study aimed to investigate the effects and mechanisms of high-frequency short-pulse gastric electrical stimulation (GES) on gastric emptying and specific myenteric neurons of the gastric antrum in healthy beagle dogs. Four healthy…

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Negative / Null Result ReportMedicine

Associations Between Social Determinants of Health and Cardiovascular Complications After Hand Surgery: Examining the Role of Income, Unemployment, Insurance, and Education.

Sabet, Young, Lowder et al. · 2026 · Journal of surgical orthopaedic advances

This study examines the impact of social determinants of health (SDoH) on cardiovascular complications after hand surgery, focusing on income, unemployment, insurance, and education. Using PearlDiver data (2011 - 2022), adult patients with…

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Negative / Null Result ReportMedicine

Unilateral Ankle Exoskeleton Assistance Reshapes Gait: Temporal Parameters, Load Distribution, and Inter-Limb Symmetry.

Wang, Ding, Jing et al. · 2026 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Wearable exoskeletons have shown efficacy in gait rehabilitation and locomotor enhancement. Despite much work on the physiological and biomechanical aspects of human-exoskeleton interaction, systematic investigations into how exoskeleton…

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Negative / Null Result ReportMedicine

Evaluation of the Effects of Diabetes Mellitus and Periodontitis on Alveolar Bone Radiodensity Using Hounsfield Unit Measurement and Fractal Analysis.

Acipinar, Deveci, Balel · 2026 · Journal of imaging informatics in medicine

This retrospective study aimed to evaluate the effects of diabetes mellitus and periodontitis on alveolar bone density and trabecular bone quality using cone-beam computed tomography (CBCT) and to compare fractal analysis with Hounsfield…

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Negative / Null Result ReportMedicine

MALICoT: A pilot cross-sectional study analyzing the effects of power training and age on endomysium content and fiber area in the soleus muscle of adult males.

Clemen, Humbsch, Berwanger et al. · 2026 · Physiological reports

The cross-sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty-three clinically healthy male…

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Negative / Null Result ReportMedicine

The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.

Schlemmer, Hammer, Fandler-Höfler et al. · 2026 · Nutrients

Background : The plant Griffonia simplicifolia is marketed as a dietary supplement; it is said to have antidepressant and sleep-promoting properties. Its main ingredient, 5-hydroxytryptophan (5-HTP), is the immediate precursor of serotonin…

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Negative / Null Result ReportMedicine

Clinical Strategies to Improve the Accuracy of Articulating Paper for Detecting Occlusal Contact Points in Adults with Natural Dentitions.

Rovira-Lastra, ElOtmani-Sabiri, Ustrell-Barral et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This clinical study assessed the validity of articulating paper for detecting occlusal contacts points, including examining the effects of clinical technique, paper thickness, and the arch. Methods : This…

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Negative / Null Result ReportMedicine

Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.

Ahmed, Nath, Jahan et al. · 2026 · International journal of environmental research and public health

Conventional anthropometric measures used to predict dyslipidemia, such as body mass index and waist circumference, vary over time and may not fully capture early-life influences on metabolic risk. Fixed skeletal proportions, including…

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Negative / Null Result ReportMedicine

Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.

Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine

Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…

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Negative / Null Result ReportMedicine

Hope for Romantic Relationships: Validation of a Brief Scale.

Marici, Marina, Cormoș · 2026 · Behavioral sciences (Basel, Switzerland)

This study aimed to develop and validate a brief measure of hope for romantic relationships (HRR), conceptualized as a future-oriented evaluation of relational continuity and quality. The sample consisted of 525 participants. Exploratory…

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Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

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Negative / Null Result ReportMedicine

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin.

Hayashi-Wells, Phark, Duarte · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.…

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