19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…
View details →Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery
OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…
View details →Regidor E, Dionigi C, Ghoraishi M et al. · 2026 · Journal of periodontal research
Aims To evaluate the adjunctive effect of enamel matrix derivative (EMD) in the reconstructive surgical therapy of peri-implantitis. Methods Forty subjects (44 implants) affected by peri-implantitis (PPD ≥ 5 mm, positive BOP/SOP,…
View details →Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…
View details →Xu J, Wang H, Chen J et al. · 2025 · International journal of surgery (London, England)
Background Autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis and osteoarthritis, are debilitating conditions with limited curative options. Stem cell therapy offers promising regenerative and immunomodulatory benefits.…
View details →Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research
Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…
View details →Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research
Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…
View details →Costa TE, Lauar JC, Innecchi MLR et al. · 2026 · Journal of the Endocrine Society
Introduction New evidence has emerged linking uric acid levels to Chronic Kidney Disease and Mineral and Bone Disorder (CKD-MBD). However, interventional studies remain scarce. We evaluated the effect of allopurinol on CKD-MBD biomarkers.…
View details →Ru X, Wu L, Guo Y et al. · 2025 · Medicine
Given that homocysteine (Hey) may be a viable target for intervention and that there is uncertainty regarding the causal relationship between plasma Hcy levels and colorectal cancer (CRC), this study used Mendelian randomization (MR) to…
View details →Crespo R, Poudel I, Malheiros DM et al. · 2024 · Journal of Applied Poultry Research.
This study aimed to compare the performance of 2 quantitative ultrasound (QUS) devices and to investigate the possible relationship between bone density, measured by speed of sound (SOS), and the biomechanical properties of bone. The bone…
View details →Aziz YN, Aragon Garcia R, Plummer P et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized trials showed no benefit of mechanical thrombectomy (MT) for ischemic stroke due to distal medium vessel occlusion (DMVO). We sought to understand the use of MT for DMVO stroke treatment before and after the…
View details →Niazi SK · 2024 · International journal of molecular sciences
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…
View details →Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine
Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…
View details →Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research
Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…
View details →Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society
Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…
View details →Matera MG, Calzetta L, Rogliani P et al. · 2025 · International journal of chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with limited response to standard anti-inflammatory therapies. Biologics targeting specific inflammatory pathways have emerged as potential treatments,…
View details →De Pascale G, Cutuli SL, Vargas M et al. · 2026 · Intensive care medicine
Purpose The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (Pcuff) based on exhaled CO 2 measurement combined with automatic subglottic space drainage (SSD) may prevent tracheal…
View details →Bano S, Choudhry N, Numan A et al. · 2026 · Journal of clinical medicine
Background : Circulating cytokines and their soluble receptors in body fluids have been implicated in the pathogenesis of multiple sclerosis (MS). Alterations in serum levels of pro- and anti-inflammatory cytokines and/or their soluble…
View details →Wang Y, Niu Y, Qin B et al. · 2025 · Ecology and evolution
Perlidae represents one of the most diverse and ecologically important groups within the order Plecoptera. However, the phylogenetic relationships within Perlidae remain unresolved due to morphological plasticity and the limited…
View details →Flores-Prado V, Godoy-Padilla D, Limaymanta-Zavala M et al. · 2025 · Journal of advanced veterinary and animal research
Objective The study assessed the anthelmintic activity of Artemisia absinthium ethanolic extract for controlling gastrointestinal nematodes in goats, both in vitro using infective larvae and in vivo in naturally infected goats under…
View details →Feygin MS, Brenner A, Tanweer O · 2025 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Background The management of acute ischemic stroke (AIS) was revolutionized within the last 15 years with the introduction of mechanical thrombectomy (MT) to standard of care. Despite the success of mechanical thrombectomy (MT) in…
View details →Rodgers J, Brothers T · 2024 · Preprint
Abstract Purpose: Blind tunneling of subfascial femoropopliteal bypass grafts may result in inadvertent graft passage through the sartorius. The purpose of this study was to determine whether intramuscular passage of femoropopliteal bypass…
View details →Tidadini F, Trilling B, Sage PY et al. · 2024 · Techniques in coloproctology
Background The enhanced recovery after surgery (ERAS) protocol has been introduced over the past three decades for patients undergoing colorectal surgery. However, the effect of this program on long-term survival is poorly studied. We…
View details →Rohan T, Turchetta G, Yang S · 2024 · Preprint
Abstract Importance: It is hypothesized that 5α-reductase inhibitors (5aRI) increase aromatase-mediated conversion of testosterone to estrogen, which may facilitate development of estrogen-driven malignancy. Previous studies in male…
View details →Matheux A, Collas L, Grisard M et al. · 2024 · Cancer chemotherapy and pharmacology
Objectives The use of plasma uracil measurements to detect dihydropyrimidine dehydrogenase (DPD) deficiency is one of the methods for preventing toxicities associated with fluoropyrimidines, including 5-Fluorouracil (5-FU). Unfortunately,…
View details →He W, Ding L, Liu Z et al. · 2025 · JAMA network open
Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight…
View details →Kim Y, Salazar-Marioni S, Abdelkhaleq R et al. · 2025 · Scientific reports
The role of intravenous thrombolysis (IVT) in combination with endovascular thrombectomy (EVT) for the treatment of large vessel occlusion acute ischemic stroke has been evaluated exclusively outside the US, in randomized clinical trials…
View details →Santucci J, Hua C, Chong L et al. · 2025 · ANZ journal of surgery
Background Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for…
View details →Byrne RA, Hahn JY, O'Kane P et al. · 2025 · JACC. Cardiovascular interventions
Background In recent years, drug-coated balloon (DCB) angioplasty has become an established treatment option for the treatment of coronary in-stent restenosis (ISR). Objectives The aim of this study was to compare the angiographic and…
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