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Browse the failure-mode index

20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Longitudinal Changes in Sensory Processing and Clinical Outcomes During Spinal Cord and Dorsal Root Ganglion Stimulation to Treat Chronic Pain: A Pilot Study.

Rogers ER, Sankarasubramanian V, Kyi WHT et al. · 2025 · Journal of pain research

Purpose The analgesic mechanisms and neurophysiological effects of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) are poorly understood. In this pilot repeated-measures study, we used quantitative sensory testing…

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Negative / Null Result ReportOpen accessMedicine

Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.

Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…

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Negative / Null Result ReportOpen accessMedicine

Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.

Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…

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Negative / Null Result ReportOpen accessMedicine

The Localization Accuracy of Electrically Evoked Dental Sensations.

Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research

Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…

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Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

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Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

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Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

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Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

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Negative / Null Result ReportOpen accessMedicine

Derived hematological indices during peripheral blood stem cell mobilization in the plerixafor era: insightful dynamics but limited predictive value.

Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…

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Negative / Null Result ReportMedicine

Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Rebel HG, de Gruijl FR · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

We reported earlier that adult FabplCre;Apc 15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that…

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Negative / Null Result ReportMedicine

Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.

Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition

Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…

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Negative / Null Result ReportMedicine

Ultrasound-Guided Superficial Parasternal Intercostal Plane Block for Early Pain Management in Patients Undergoing Cardiac Surgery-A Randomized Controlled Trial.

Kalli AJ, Mäkelä P, Huhtala H et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Sternotomy causes substantial postoperative pain. Recently, several less invasive nerve blocks have been described that are safer to use even on anticoagulated patients. This study aims to evaluate early pain management using…

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Negative / Null Result ReportMedicine

Thoracic duct ligation during esophagectomy fails to prevent chylothorax or improve survival: a propensity score matched cohort study.

Quan S, Xie H, Zhang D et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Postoperative chylothorax is a serious complication following esophagectomy. The efficacy of thoracic duct ligation (TDL) for chylothorax prevention is controversial. This study aimed to evaluate the impact of TDL on chylothorax…

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Negative / Null Result ReportMedicine

The Effect of Bariatric Surgery on Complication Risk Following Total Hip Arthroplasty in Patients with Morbid Obesity.

Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…

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