19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Barbarot S, Aubert H, Boivin M et al. · 2026 · The British journal of dermatology
Background New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention…
View details →Altvater EE, Kojh D, Huang R et al. · 2025 · Preprint
ABSTRACT In metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis is the most important prognostic factor, and fibrosis can lead to hepatic cirrhosis and cancer. In the liver toll-like receptor 4 (TLR4) signaling…
View details →Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Preprint
Background: /Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…
View details →Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
View details →Villard M, Espinosa-Carrasco G, Hernandez J · 2025 · Preprint
ABSTRACT Lymphodepletion, which is currently used as adjuvant for adoptive cytotoxic T cell immunotherapy in cancer, promotes the breakdown of peripheral CD8 + T cell tolerance. Under lymphopenic conditions, naive T cells proliferate due…
View details →Kalafut KC, Cormerais Y, Cissé MY et al. · 2025 · Preprint
The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, while aberrant activation is linked to human disease, including metabolic disease. Cellular…
View details →Jordhani M, Ruci D, Jordhani P et al. · 2025 · Preprint
Background: Hydroxychloroquine (HCQ) is a disease-modifying antirheumatic drug used in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other autoimmune diseases. Although HCQ reduces SARS-CoV-2 replication in vitro at…
View details →Ryan BC, Griffith KE, Geczi CN et al. · 2025 · Preprint
Stargardt disease (STGD1) is the most common inherited macular dystrophy, caused by loss-of-function mutations in ABCA4 that result in bisretinoid-containing lipofuscin accumulation in the retinal pigment epithelium (RPE), and progressive…
View details →Caltabiano A, Voruganti A, Nesi J et al. · 2026 · JMIR serious games
Background Exposure and response prevention is a first-line intervention for obsessive-compulsive disorder (OCD), yet many individuals with contamination concerns do not access care. Virtual reality exposure-based therapy (VRET) may…
View details →Rau KK, Harrison BJ, Venkat G et al. · 2025 · Preprint
Pain resulting from tissue damage, including surgical incision, is often only partially responsive to standard treatments focusing on inflammation, suggesting additional mechanisms are involved. Tissue damage leads to expression in dorsal…
View details →Heller DT, Benites NM, Amick EM et al. · 2025 · Preprint
Pre-sensory (ps), peripherally-generated spontaneous activity (SA) is important for establishing basic topography of central components of sensory pathways. However, roles for psSA in sculpting connections at the single neuron level and in…
View details →Kik OE, Zaviska F, Lesage G et al. · 2026 · Water research
This study investigated the electro-oxidation (EO) of three priority micropollutants: carbamazepine (CBZ), diuron (DIU), and perfluorooctane sulfonate (PFOS), in secondary-treated wastewater using boron-doped diamond (BDD) anodes. Although…
View details →Bidon M, Saito T, Skjaerven KH et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)
Methylmercury (MeHg) is a pervasive neurotoxicant threatening aquatic ecosystems. Selenium (Se) has been reported to protect fish against the adverse MeHg toxicity, yet molecular investigations of their interaction in the brain remain…
View details →Birsen I, Erdogan K, Ozsoy O et al. · 2026 · Tissue & cell
Inflammatory bowel disease (IBD) is a systemic condition that can also lead to extraintestinal complications, including liver damage. Disruptions in the gut-liver axis and inflammatory mediators play a key role in this process. Apelin, a…
View details →Dai T, Dai Q, Ding Y et al. · 2026 · Neurochemical research
Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibition of histone deacetylases (HDACs) may convert microglia to a branching state and thus prevent neuroinflammation.…
View details →de Boer N, Vučko Z, Koster DI et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Antipsychotic-induced weight gain (AiWG) is a common, burdensome adverse effect. Switching to antipsychotics with lower metabolic risks, such as aripiprazole, is recommended, but long-term data is limited. Long-acting injectables (LAIs)…
View details →Sholikah TA, Septyaningtrias DE, Sumiwi YAA et al. · 2025 · Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
Background this study aimed to examine the impact of a TNF-α antagonist on markers of neuronal death, the total number of myenteric neurons, and the volume of each colonic layer in diabetic rats. Methods thirty male rats were divided into…
View details →Carmon L, Nassar M, Idan D et al. · 2026 · Journal of clinical medicine
Background/Objectives : Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by impaired glycosaminoglycan degradation, leading to multisystem involvement and progressive growth impairment. Longitudinal growth data in…
View details →Cedeno Escobar AM, Walstrom KM · 2025 · microPublication biology
Imbalances between pathogenic and commensal bacteria cause microbial dysbiosis that disrupts host development. Streptococcus mutans ' virulence factors promote human oral cell colonization, leading to dysbiosis if unchecked. When grown…
View details →Goldberg TS, Shalem Y, Fujinaga D et al. · 2025 · Journal of insect physiology
Juvenile hormones (JHs) are key insect endocrine signals regulating pre-adult development and adult life history strategies, physiology, and behavior. The importance of this endocrine signal has led to the development of insecticides…
View details →Kitaoka Y, Tsukahara C, Fujita N et al. · 2025 · International ophthalmology
Purpose Intravitreal injections of some drugs such as anti-VEGF antibodies are available for certain human ocular diseases. Meanwhile, inhibition of SARM1 has been reported to exert neuroprotection in several neurodegenerative disease…
View details →Garofolo IC, Santos PF, Silva MF et al. · 2026 · Nutrition and health
Background: Type 2 Diabetes Mellitus is a metabolic disease characterized by hyperglycemia and hyperinsulinemia, closely linked to obesity. According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20-79…
View details →Lee SU, Choi SK, Song JM et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective Aspirin is recommended for women with pregestational diabetes mellitus (PGDM) because they are at a high risk for preeclampsia. However, previous studies have predominantly examined the effect of aspirin on high-risk groups, with…
View details →Miguéns MV, Quintela-Vilariño C, Casado S et al. · 2026 · Life sciences
Scope Global increase in obesity and metabolic syndrome has led to a marked rise in comorbidities, with liver disease emerging as a major concern. Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over 30% of the…
View details →Martins DS, Demasi M, de Lima Bellan D et al. · 2025 · Biochemical and biophysical research communications
The development of resistance by tumor cells is a challenge in cancer treatment; either in chemotherapy, immunotherapy and targeted therapy. Proteasome can be considered a promising therapeutic target, as it is considered the key to the…
View details →Abhyankar SD, Luo Q, Hartman GD et al. · 2025 · Preprint
The APOE genotype influences metabolic and neurodegenerative outcomes, with APOE4 carriers at higher risk for Alzheimer’s disease (AD) and metabolic dysfunction. This study examines how long-term dietary interventions affect systemic…
View details →Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International Journal of Food Microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
View details →Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism
Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…
View details →Seekings AH, Billington E, Mahmood S et al. · 2026 · Virology
H7N7 low-pathogenicity avian influenza virus (H7N7-LPAIV) incursions preceded emergence of H7N7 high-pathogenicity (HP)AIV at several European layer hen outbreaks. Evidence from a UK layer H7N7-HPAIV (2008) outbreak informed in vivo…
View details →Carvalho AVS, Hoeper ES, Dúran-Carabali LE et al. · 2026 · The Journal of nutritional biochemistry
Neonatal hypoxia-ischemia (HI) is one of the main causes of perinatal death and is commonly associated with neurological damage which are usually observed on motor and cognitive domains. Plinia trunciflora or "jabuticaba" is a native…
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