e-ISSN: Pending

Browse the failure-mode index

20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of ruminally protected lysine on growth and nitrogen balance of grain-finished beef cattle fed diets of decreasing protein concentration.

Herzog DS, Jo J, Nakajima D et al. · 2026 · Translational animal science

Two experiments were conducted to determine the effect of ruminally protected lysine (AjiPro-L) supplementation on performance and nitrogen (N) balance of feedlot cattle fed decreasing concentrations of dietary protein. Diets contained (DM…

View details →
Negative / Null Result ReportMedicine

Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.

Medina Muñoz M, Gallego Campillo S, Martín Peinador Y et al. · 2026 · Indian pediatrics

Objective Lower respiratory tract infections (LRTIs) are a common cause of primary care visits in infants. This study was done to evaluate the course of LRTIs before-and-after the introduction of nirsevimab and to identify the associated…

View details →
Negative / Null Result ReportMedicine

Impacts of temporal discrepancies between basal sap flow and canopy transpiration on estimating canopy ozone uptake in a warm temperate coniferous forest.

Tanaka R, Tokai S, Oi N et al. · 2026 · The Science of the total environment

Sap flow measured at basal trunk (Fd_base) has been used to estimate canopy transpiration and ozone uptake in forests. Although diurnal patterns of Fd_base do not always correspond to those of canopy transpiration, little is known about…

View details →
Negative / Null Result ReportMedicine

The effect of Sebia's CZE IFCC-converted results on carbohydrate-deficient transferrin (CDT) interpretation in driver's license assessments.

Debunne N, De Letter K, Delanghe J et al. · 2026 · Clinical chemistry and laboratory medicine

Objectives Carbohydrate-deficient transferrin (CDT) is a specific biomarker for chronic excessive alcohol consumption. The IFCC Working Group on CDT Standardization recommends 2-sialo-transferrin (2-sialo-Tf) as the sole measurand, with a…

View details →
Negative / Null Result ReportMedicine

Outcomes of Patients With Mitral Stenosis With Prior Percutaneous Mitral Commissurotomy Undergoing Mitral Valve Surgery.

Ruangsubvilai N, Au-Yeung K, Wongbuddha C et al. · 2026 · The American journal of cardiology

Limited data exist on outcomes for patients with mitral stenosis (MS) who have previously undergone percutaneous mitral commissurotomy (PMC) and later require surgical mitral valve replacement (MVR). This study evaluates the impact of…

View details →
Negative / Null Result ReportMedicine

Good enough assessment: A comparison of brief screener and detailed interview assessments of borderline personality disorder symptoms in a clinical research setting.

Furtado Fernandes L, Davis MT, Luo W et al. · 2026 · Personality disorders

Structured clinical interviews are the gold standard for identifying borderline personality disorder (BPD) in research. No self-report instrument has been validated as a replacement tool for BPD diagnosis. However, clinical interviews can…

View details →
Negative / Null Result ReportMedicine

Does Resident Involvement Affect Clinical Outcomes and Postoperative Complication Rates in Orthopaedic Sports Medicine Surgery?

Stokes DJ, Cram TR, Pasic N et al. · 2026 · The American journal of sports medicine

Background The "July effect" suggests increased patient morbidity and mortality during the early academic year due to new resident involvement. Evidence specific to orthopaedic sports medicine is limited. Purpose To evaluate the effect of…

View details →
Negative / Null Result ReportMedicine

Effect of clarithromycin versus placebo on risk of atrial fibrillation.

Jensen GB, Olsen MH, Jensen MT et al. · 2026 · Danish medical journal

Introduction The CLARICOR randomised trial of clarithromycin versus placebo in patients with stable ischaemic heart disease found increased all-cause and cardiovascular mortality after a brief clarithromycin regimen, suggesting a possible…

View details →
Negative / Null Result ReportMedicine

Rates of Arthrofibrosis in Adolescent Patients After ACL Reconstruction Using Hamstring Autograft With or Without Lateral Extra-articular Tenodesis.

DeFrancesco CJ, Cavendish E, Kocher MS · 2026 · The American journal of sports medicine

Background Lateral extra-articular tenodesis (LET) can reduce the risk of graft failure after anterior cruciate ligament (ACL) reconstruction in adolescents and young adults. It is unclear whether the use of this procedure increases risks…

View details →
Negative / Null Result ReportMedicine

Surgical complications after therapeutic lymph node dissection in stage III-IV melanoma: impact of neoadjuvant immunotherapy.

Lytchiér JVC, Okur MI, Rutkowski W et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant immune checkpoint inhibitors (ICI) have recently entered clinical practice in management of melanoma, yet its impact on surgical outcomes remains unclear. This study evaluated the influence of neoadjuvant ICI on…

View details →
Negative / Null Result ReportMedicine

Obstructive sleep apnea increases recurrent cardiovascular event risk in younger but not older patients with acute coronary syndrome: a prospective cohort study.

Gong W, Chen X, Zhao W et al. · 2026 · Sleep medicine

Background Obstructive sleep apnea (OSA) and age are strongly associated with recurrent events following acute coronary syndrome (ACS), but their interaction is unclear. This study was designed to evaluate the age-dependent impact of OSA…

View details →
Negative / Null Result ReportMedicine

Caffeine Supplementation Increases Muscle Strength, but Not Endurance, While Both Caffeine and Its Expectation Elevate Blood Lactate: A Balanced-Placebo Design Study.

Soares EMKVK, da Cruz CJG, Ives SJ et al. · 2026 · Nutrients

Objectives : To determine whether caffeine supplementation and its expectancy influence muscle strength (ST) and muscle endurance (ME) using a balanced-placebo design. Methods: Using a randomized, double-blind, balanced-placebo design,…

View details →
Negative / Null Result ReportMedicine

Do Respiratory Viruses Cause Leaky Gut Syndrome?

Karataş ŞN, Çağan E, Demirören K et al. · 2025 · Turkish archives of pediatrics

Objective Increased intestinal permeability is associated with the development of allergic and autoinflammatory diseases. Zonulin is a key physiological regulator of tight junctions in the intestinal epithelium. Thymus-expressed chemokine…

View details →
Negative / Null Result ReportMedicine

Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study.

Kloosterman R, Dinh T, Michaeli J · 2026 · Journal of assisted reproduction and genetics

Purpose The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological…

View details →
Negative / Null Result Report

Effect of insect exclusion screens on insect pests in high tunnels

Quesada CR, Batson C, Holaskova I et al. · 2025 · Preprint

Abstract High tunnels can use insect exclusion screens as a mechanical pest control method within integrated pest management (IPM) programs. The impact of insect screens was evaluated on several tomato pests in commercial high tunnels. The…

View details →
Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitors Did Not Exacerbate Autoimmune Rheumatic Disease Activity in Patients With Cancer.

Tsai PH, Hsieh CI, Kuo YC et al. · 2026 · Journal of the National Comprehensive Cancer Network : JNCCN

Background The safety of immune checkpoint inhibitors (ICIs) in patients with cancer and preexisting or acquired autoimmune rheumatic diseases (ARDs) remains unclear. This study aimed to evaluate the safety of ICIs in patients with cancer…

View details →