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Browse the failure-mode index

19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Neural and vascular cellular adhesion molecules are associated with cognitive function in patients with schizophrenia-spectrum disorders: A longitudinal study.

Varden Gjerde K, Bartz-Johannessen C, Løberg EM et al. · 2026 · Schizophrenia research

Background Schizophrenia patho-etiology may involve endothelial inflammation and blood-brain barrier (BBB) dysregulation with cellular adhesion molecules (CAMs) as important mediators. CAMs are essential for cellular integrity but can show…

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Negative / Null Result Report

Associations between knowledge of multilingual support resources and attitudes towards, and use of, ad hoc interpreters in pharmacies in Aichi Prefecture, Japan

Hashimoto C, Yoshino A, Hida S et al. · 2025 · Preprint

Abstract Background With the increasing diversity of nationalities in Japan, the number of foreign patients with limited Japanese language proficiency is growing. While various multilingual support resources have been developed in recent…

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Negative / Null Result ReportMedicine

Racial Self-Efficacy and Ethnic Identity in the Context of Neighborhood Violence and Internalizing Symptoms Among Black and Latinx youth: An Application of the Minority Stress Theory.

Weerakoon SM, Henson-Garcia M, Rose R et al. · 2025 · Community health equity research & policy

BackgroundBlack and Latinx youth are disproportionately exposed to neighborhood violence and related mental health challenges. Racial-ethnic identity shapes how adolescents perceive, interpret, and cope with stressful environmental…

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Negative / Null Result ReportMedicine

Parental language mixing and its association with language outcomes of children with (a suspicion of) Developmental Language Disorder.

van Witteloostuijn M, Blom E · 2025 · Journal of communication disorders

Multilingual children naturally encounter language mixing in their environment. Since children's language development depends on their language input, and processing language mixing in the input may be cognitively demanding, the amount of…

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Negative / Null Result ReportMedicine

No effect of mental fatigue on perceived hand weight.

Pizzolla E, Fiorio M, Marotta A et al. · 2026 · Quarterly journal of experimental psychology (2006)

Fatigue has a profound impact on various sensory and perceptual processes; yet, its effects differ depending on whether it arises from physical or mental exertion. While physical fatigue is known to alter body weight perception, it remains…

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Negative / Null Result ReportOpen accessMedicine

A Four-Day Cold Shower Protocol Does Not Increase Salivary Testosterone in a Small Cohort of Male Athletes: A Research Communication.

Traylor DA, Nunes EA, Lees MJ et al. · 2026 · Health science reports

Background and aim Testosterone is an important hormone in male physiology, playing a key role in reproductive function, muscle growth, bone mineral density, and metabolic regulation. Cold exposure is celebrated in fitness and wellness…

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Negative / Null Result ReportMedicine

Does scaphoid fracture surface morphology correlate with fracture stability?

Frish Simcovich Y, Eigner E, Joskowicz L et al. · 2026 · The Journal of hand surgery, European volume

We examined the correlations between the surface morphology of acute scaphoid fractures and their stability. Our hypothesis was that a more irregular fracture surface would have a stabilizing effect on the fracture. A total of 75 isolated…

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Negative / Null Result ReportMedicine

Contribution of vestibular afference to estimation of centre of mass state for stabilization of walking differs between anteroposterior and mediolateral directions.

Li YC, Lemaire KK, Bruijn SM et al. · 2025 · Neuroscience

Walking without falling requires correcting the deviations of the centre of mass (CoM) trajectory relative to the base of support. This process is partially under feedback control. We investigated whether vestibular afference contributes…

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Negative / Null Result ReportMedicine

Crude protein oscillation in diets adequate and deficient in metabolizable protein: Effects on nutrient digestibility, nitrogen balance, plasma amino acids, and greenhouse gas emissions.

Erickson MG, Reinhardt LA, Svaren L et al. · 2024 · Journal of dairy science

Reducing dietary CP is a well-established means to improve N use efficiency. Yet, few studies have considered if transient restrictions in dietary CP could reduce the environmental footprint of late-lactation cows. We hypothesized that the…

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Negative / Null Result ReportOpen accessMedicine

Acute effects of anodal transcranial direct current stimulation on maximal voluntary force, repeated maximal isometric contractions and corticospinal excitability in healthy young adults.

Colomer-Poveda D, Mera-González I, Marcos-Frutos D et al. · 2026 · European journal of applied physiology

PURPOSE: The aim of this triple-blind, placebo-controlled study was to determine the effects of anodal transcranial direct current stimulation (a-tDCS) applied over the primary motor cortex (M1) and the dorsolateral prefrontal cortex…

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Negative / Null Result ReportOpen accessMedicine

Investigating the impact of COVID-19 related worries and loneliness on alcohol consumption: an ecological momentary assessment.

Haucke M, Heinz A, Heinzel S et al. · 2025 · European archives of psychiatry and clinical neuroscience

Adverse alcohol consumption is a major public health concern, which might have been further increased by the COVID-19 pandemic. In this study we investigated the impact of a lockdown stage on the association between alcohol consumption,…

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Negative / Null Result ReportMedicine

Investigating Sex Differences in the Association of Disclosure and Concealment of Sexual Minority Identity With Cardiovascular Health in the CARDIA Cohort at Year 35.

Hascher K, Brown R, Janulis P et al. · 2026 · Biopsychosocial science and medicine

Objective Sexual minority (SM) populations experience worse cardiovascular health than heterosexual populations. One potential pathway is the effects of disclosure (sharing) or concealment (withholding) of SM identity due to anticipated…

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Negative / Null Result ReportMedicine

Limits of verbal labels in cognition: Category labels do not improve visual working memory performance for obfuscated objects.

Chung YH, Williams LH, Brady TF et al. · 2025 · Journal of experimental psychology. General

Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here, we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…

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Negative / Null Result ReportMedicine

Acute Effects of Myeloperoxidase Inhibition on Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.

Popovic D, Reddy YNV, Omar M et al. · 2025 · Mayo Clinic proceedings

Objective Myeloperoxidase (MPO) is a heme peroxidase that scavenges nitric oxide and contributes to microvascular dysfunction. Patients with heart failure and preserved ejection fraction (HFpEF) have microvascular dysfunction that leads to…

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