19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wittenborn J, Cuma C, Kennes LN et al. · 2026 · Diagnostics (Basel, Switzerland)
Objective: The aim of this study was to evaluate the positive predictive value of endocervical curettage (ECC) during colposcopic examination in a dysplasia unit since the implementation of the new cervical cancer screening program in…
View details →Mu Y, Jing Y, Liu X et al. · 2026 · International journal of women's health
Background Non-invasive prenatal testing (NIPT) is widely adopted for its high sensitivity in detecting chromosomal abnormalities, but its accuracy for placental and fetal mosaicism is limited due to reliance on placental DNA, leading to…
View details →Iamchaimongkol A, Leeareekun K, Chira-Adisai W et al. · 2026 · Journal of rehabilitation medicine
Objective To assess the correlation between controlled-pressure provocative test duration and electrodiagnostic severity in carpal tunnel syndrome. Design Cross-sectional correlational study. Patients Patients with clinical symptoms…
View details →Nanni AG, Urso D, Caccamo M et al. · 2024 · Journal of Alzheimer's disease reports
This report presents a challenging case of Creutzfeldt-Jakob Disease (CJD), a rare and rapidly progressing neurological disorder. The patient exhibited diverse and progressive neuro-psychiatric symptoms, including memory impairment,…
View details →Kim JH, Shin JY, Park SY et al. · 2024 · Scientific reports
The somatic BRCA1 or BRCA2 Pathogenic Variant (PV)/Likely PV (LPV) from Next Generation Sequencing (NGS) is the most important biomarker for PARP inhibitor use and maintenance-targeted therapies. A discrepancy in the detection rates of…
View details →Heyman Y, Röjlar H, Hawranek C et al. · 2026 · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
PURPOSE: As genetic testing becomes increasingly integrated into routine care, understanding its impact on psychological well-being and health-related quality of life (HRQoL) is essential. This study assessed HRQoL, anxiety and cancer…
View details →Vega-Gonzalez J, Toro JAC, García EL et al. · 2025 · Genes, chromosomes & cancer
According to the 5th edition of the WHO Classification of Soft Tissue and Bone Tumors, the diagnosis of synovial sarcoma relies on morphology, immunohistochemistry, and the detection of a specific fusion involving the SS18 gene with a…
View details →Taechikantaphat M, Kongchareon A, Julapanthong P et al. · 2026 · Veterinary and animal science
This prospective, randomized clinical trial compared the therapeutic efficacy and rate of platelet recovery of doxycycline 10 mg/kg once daily (SID) (Group A, n=17) versus 5 mg/kg twice daily (BID) (Group B, n=12) in 29 dogs naturally…
View details →Pimentel V, Becker J · 2025 · Arquivos de neuro-psiquiatria
Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune demyelinating disease characterized by a high risk of relapse and disability. In cases positive for aquaporin 4-immunoglobulin G (AQP4-IgG), long-term immunosuppression…
View details →Mazzotta E, Natale A, Bellinati L et al. · 2025 · Animals : an open access journal from MDPI
Equid milk (donkey or mare) has traditionally been consumed raw or fermented due to its distinctive chemical composition, which closely resembles human milk, and its nutritional benefits. Nowadays, interest in it is increasing, despite…
View details →Bai M, Li Y, Gao Q et al. · 2025 · Virology journal
Purpose Present study aimed to compare the boiling and magnetic bead nucleic acid extraction method for HPV genotypes detection. Methods By mixing hemoglobin with HPV positive quality control products, the anti-interference ability of two…
View details →Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…
View details →Wang X, Fan Z, Huo L et al. · 2025 · Breast care (Basel, Switzerland)
Background In sentinel node biopsy (SNB) procedure for breast cancer patient, whether the abnormal node was excised is uncertain. The impact of abnormal node on the accuracy of SNB results is unknown. Methods In this prospective study,…
View details →Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
View details →Roman TS, Gray SM, Sneddon TP et al. · 2026 · HGG advances
The impact of clinical exome and genome sequencing (ES/GS) depends on the clinical setting. In the sequencing arm of a multifactor randomized clinical trial to evaluate broadening access, we assessed the diagnostic and inconclusive…
View details →Bölük S, Bölük S · 2025 · Cureus
Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…
View details →Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
View details →Buteau JP, Moon D, Fahey MT et al. · 2026 · The Lancet. Oncology
Background MRI is recommended for men with clinical suspicion of significant prostate cancer. Those with high clinical risk but non-suspicious or equivocal MRI often undergo prostate biopsy, but have a low likelihood of clinically…
View details →Paturu T, Shukla A, Shivan SG et al. · 2024 · Journal of cataract and refractive surgery
Evidence-based decision-making is generally based on published evidence. Therefore, if the published evidence is biased, so will the decision-making. One possible bias is the "positive-results" publication bias. This study attempts to…
View details →Lydia S, Blaise G · 2024 · Journal of travel medicine
Background When malaria is suspected in case of fever after travel in endemic areas, the current recommendation is to repeat the malaria test at 24-hour intervals, with up to two additional tests, as long as the test result is negative. A…
View details →Teixeira J, Teixeira D, Coelho A et al. · 2026 · Dermatology practical & conceptual
Introduction Systemic amyloidosis is a rare disorder characterized by extracellular amyloid deposition in tissues, leading to variable organ dysfunction. Abdominal wall fat pad biopsy is widely used as a minimally invasive diagnostic…
View details →Jean J, Sukhanova M, Dittmann D et al. · 2024 · Case reports in hematology
Chronic myeloid leukemia (CML) is associated with several breakpoint regions that result in different BCR::ABL1 fusion transcripts. These include the major breakpoint region (M-BCR), minor breakpoint region (m-BCR), and mu breakpoint…
View details →Mateuszczyk MK, Łyko M, Bieniek A et al. · 2025 · Clinics and practice
Background: Adverse reactions to tattoo pigments are increasingly recognized, yet severe systemic complications remain rare and poorly characterized. Red tattoo ink, in particular, is associated with delayed hypersensitivity reactions, but…
View details →Chunkul S, Sathirapatya T, Dangklao P et al. · 2025 · Forensic science international. Synergy
Sexual assault is a terrible crime that demands a comprehensive and skilled investigation to gather the perpetrator's biological material. To collect all possible physical and biological evidence, forensic investigation is crucial and…
View details →Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
View details →Ma F, Hu J, Bai M et al. · 2024 · Clinical laboratory
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2…
View details →Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics
Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…
View details →Cassileth LB, Killeen K, York A et al. · 2026 · Aesthetic surgery journal. Open forum
Background Mastectomy skin flap necrosis (MSFN) is a critical postoperation complication in postmastectomy breast reconstruction. High replacement tissue expander fill volume and large mastectomy specimen size are commonly assumed to…
View details →Akella JS, Onken BD, Sedore CA et al. · 2026 · microPublication biology
The Caenorhabditis Intervention Testing Program aims to identify lifespan-extending interventions that are effective across diverse genetic backgrounds. Previous studies identified a role for anticonvulsants in lifespan extension in the…
View details →Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research
Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…
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