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Browse the failure-mode index

19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Original research: surfactant administration using less invasive surfactant administration (LISA) versus enhanced intubate-surfactant-extubate (ENSURE) in preterm infants.

Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics

Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…

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Negative / Null Result ReportMedicine

Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up.

Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)

Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…

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Negative / Null Result ReportMedicine

Anterior quadratus lumborum block in total hip arthroplasty: a two-center, randomized, placebo-controlled trial showing no additional benefit over multimodal analgesia.

Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine

Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…

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Negative / Null Result ReportMedicine

Levan-derived oligosaccharides (LOS) confer selective resistance against Phytophthora capsici but not Botrytis cinerea in melon and watermelon.

Yang M, Chen Y, Yang L et al. · 2026 · International journal of biological macromolecules

Plants face significant threats from pathogens while chemical pesticides remain the primary method for disease control. However, excessive use of chemical pesticides has led to increased pathogen resistance and environmental hazards,…

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Negative / Null Result ReportMedicine

The defense-inducing compound N-hydroxy pipecolic acid is a major substrate for the methyltransferase PbBSMT of Plasmodiophora brassicae.

Benade F, Jülke S, Schwelm A et al. · 2026 · Journal of experimental botany

The clubroot pathogen Plasmodiophora brassicae has an effector protein that can methylate the plant defense compound salicylic acid (SA), and the protein sequence is highly conserved in different isolates worldwide. Sequencing the…

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Negative / Null Result ReportMedicine

Early risk assessment and aspirin prophylaxis did not reduce preterm preeclampsia in Sweden: a population-based study.

Mans-Gallart N, Carlhäll S, Hildebrand E et al. · 2026 · American journal of obstetrics and gynecology

Background Preeclampsia is a substantial cause of maternal and perinatal morbimortality, with complications becoming more severe the earlier it manifests during pregnancy. The Fetal Medicine Foundation has developed a method that combines…

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Negative / Null Result ReportMedicine

Randomized field trial on the effects of on-arrival intranasal vaccination against bovine coronavirus on pneumonia and average daily gain in beef-on-dairy calves.

Jourquin S, Lowie T, Clinquart J et al. · 2026 · Journal of dairy science

This randomized clinical trial evaluated the effect of upon-arrival intranasal vaccination against bovine coronavirus (BCoV) on pneumonia risk in a beef-on-dairy veal production system. Secondary objectives were to assess the effect…

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Negative / Null Result ReportMedicine

Targeted Antimicrobial Agent Prophylaxis Fails to Reduce Peristomal Infections by Multi-Drug-Resistant Bacteria Following Percutaneous Endoscopic Gastrostomy: A Prospective Cohort Study.

Marzo-Escartín B, Villamarín-Melio M, Márquez-Algaba E et al. · 2026 · Surgical infections

Background Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial…

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Negative / Null Result ReportMedicine

A Single-Centre, Single-Blinded Randomized Control Trial Evaluating the Role of Distraction Therapy in Pain Management Following Major Abdominal Surgeries in Adult Cancer Patients.

Rana CJ, Bakshi SG, Tarhane S et al. · 2026 · Indian journal of surgical oncology

Distract trial In the post-operative period, analgesics are complemented with non-pharmacological methods (NPM). However, the evidence is limited. Objectives Randomised control trial aimed to determine the effectiveness of NPMs of pain…

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Negative / Null Result ReportMedicine

Lanthanum carbonate does not reduce urinary oxalate excretion in hyperoxaluric kidney stone formers.

Van de Perre E, Tielemans C, De Clerck D et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis Hyperoxaluria is an important risk factor for kidney stone formation. Currently available treatment options for idiopathic hyperoxaluria have limited efficacy and are difficult to maintain in the long-term.…

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Negative / Null Result ReportMedicine

Efficacy of Surgeon-Administered Regional Anesthesia in Cardiac Surgery: A Double-Blinded, 2-Center, Randomized, Placebo-Controlled Trial.

Rasmussen JJ, Bisgaard J, Hønge JL et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Managing pain after median sternotomy is a clinical challenge of balancing adequate pain relief with avoidance of excessive opioid consumption. While regional anesthesia techniques are increasingly recommended and applied in…

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Negative / Null Result ReportMedicine

Closed incisional negative-pressure wound therapy vs standard surgical dressing for groin incisions following arterial vascular surgery: A prospective multicenter randomized clinical trial.

Lenselink E, Ruig M, Grootendorst DC et al. · 2026 · Journal of vascular surgery

Objective Groin wound complications-including surgical site infections, hematomas, seroma leakage, necrosis, and wound dehiscence-are frequently reported after arterial vascular surgery and significantly impact patient morbidity and…

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Negative / Null Result ReportMedicine

Effects of tumour necrosis factor and interleukin-6 inhibitor therapy on exercise-related visceral adipose tissue reduction in rheumatoid arthritis.

Jønck S, Adamsen ML, Rasmussen IE et al. · 2026 · Experimental physiology

Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin-6 (IL-6) is upregulated…

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Negative / Null Result ReportMedicine

Primary Prophylaxis for Clostridioides difficile Infection in Lung Transplant Recipients: A Retrospective Study.

Irwin M, Leedy N, Nandavaram S et al. · 2026 · Transplant infectious disease : an official journal of the Transplantation Society

Background Clostridioides difficile infection (CDI) is a common complication in patients receiving broad-spectrum antibiotics and causes significant morbidity, especially in solid organ transplant recipients. Oral vancomycin has shown…

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Negative / Null Result ReportMedicine

Comparison of international league of associations for rheumatology and pediatric rheumatology international trials organization classification criteria for juvenile idiopathic arthritis: insights from an African multicenter cohort.

Hamdi W, Ben Nessib D, Hashad S et al. · 2025 · European journal of pediatrics

The International League of Associations for Rheumatology (ILAR) classification criteria for juvenile idiopathic arthritis (JIA) are currently widely used in clinical practice. However, new criteria have recently been proposed by the…

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