19,830 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…
View details →Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery
OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…
View details →Regidor E, Dionigi C, Ghoraishi M et al. · 2026 · Journal of periodontal research
Aims To evaluate the adjunctive effect of enamel matrix derivative (EMD) in the reconstructive surgical therapy of peri-implantitis. Methods Forty subjects (44 implants) affected by peri-implantitis (PPD ≥ 5 mm, positive BOP/SOP,…
View details →Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →Flores-Prado V, Godoy-Padilla D, Limaymanta-Zavala M et al. · 2025 · Journal of advanced veterinary and animal research
Objective The study assessed the anthelmintic activity of Artemisia absinthium ethanolic extract for controlling gastrointestinal nematodes in goats, both in vitro using infective larvae and in vivo in naturally infected goats under…
View details →Feygin MS, Brenner A, Tanweer O · 2025 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Background The management of acute ischemic stroke (AIS) was revolutionized within the last 15 years with the introduction of mechanical thrombectomy (MT) to standard of care. Despite the success of mechanical thrombectomy (MT) in…
View details →Rodgers J, Brothers T · 2024 · Preprint
Abstract Purpose: Blind tunneling of subfascial femoropopliteal bypass grafts may result in inadvertent graft passage through the sartorius. The purpose of this study was to determine whether intramuscular passage of femoropopliteal bypass…
View details →Tidadini F, Trilling B, Sage PY et al. · 2024 · Techniques in coloproctology
Background The enhanced recovery after surgery (ERAS) protocol has been introduced over the past three decades for patients undergoing colorectal surgery. However, the effect of this program on long-term survival is poorly studied. We…
View details →Rohan T, Turchetta G, Yang S · 2024 · Preprint
Abstract Importance: It is hypothesized that 5α-reductase inhibitors (5aRI) increase aromatase-mediated conversion of testosterone to estrogen, which may facilitate development of estrogen-driven malignancy. Previous studies in male…
View details →Matheux A, Collas L, Grisard M et al. · 2024 · Cancer chemotherapy and pharmacology
Objectives The use of plasma uracil measurements to detect dihydropyrimidine dehydrogenase (DPD) deficiency is one of the methods for preventing toxicities associated with fluoropyrimidines, including 5-Fluorouracil (5-FU). Unfortunately,…
View details →He W, Ding L, Liu Z et al. · 2025 · JAMA network open
Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight…
View details →GamalEl Din SF, Nabil NI, Khalil MA et al. · 2025 · Urology research & practice
Objective The present study examined the impact of measuring penile girth and length in the erect state on reassuring individuals with small penis anxiety (SPA) in the flaccid state. Methods This study included 200 potent men aged 25-40…
View details →Sköld C, Hailer NP, Mallmin H · 2026 · Acta orthopaedica
Background and purpose Denosumab may preserve periprosthetic bone mineral density (pBMD) around uncemented total hip arthroplasty (THA) components. This exploratory analysis of a previously published randomized controlled trial (RCT) aimed…
View details →Lin YH, Tsai IJ, Chang YA et al. · 2026 · Therapeutics and clinical risk management
Background Traumatic brain injury (TBI) is a major risk factor for subsequent neurodegenerative disorders. Emerging evidence suggests that statins may mitigate neuroinflammation and lipid dysregulation after TBI. This study aimed to…
View details →Dos Santos LC, da Cunha VB, Ribeiro JM et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Cocaine use disorder (CUD) remains a major public health challenge with limited effective therapeutic options. Cannabidiol (CBD) has been proposed as a potential treatment due to its neuroprotective and anti-craving properties. This…
View details →Samson T, Aali M, McBride D et al. · 2026 · Current oncology (Toronto, Ont.)
Surgical resection combined with chemotherapy offers the best chance of survival in pancreatic ductal adenocarcinoma (PDAC), but many will experience recurrence and early mortality. We examined soluble AXL (sAXL), a blood protein, for its…
View details →Ghiringhelli F, Rébé C · 2026 · Frontiers in immunology
Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non-small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor…
View details →Schweiger L, Raggam RB, Toth-Gayor G et al. · 2025 · PloS one
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk…
View details →Bespalov A, Swartz J, Knowles N et al. · 2025 · Alzheimer's research & therapy
Agitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer's disease (AD) dementia. It is associated with poor outcomes, including reduced functional ability, reduced…
View details →Massardier E, Manchec O, Bérard E et al. · 2025 · Journal of experimental orthopaedics
Purpose Numerous studies have been published on the optimal management of the patella during total knee arthroplasty (TKA), but controversy remains. The aim of this study was to compare survivorship and functional outcomes with or without…
View details →Jung JC, Ju JW, Chang HW et al. · 2024 · Journal of cardiothoracic and vascular anesthesia
Objectives This study evaluated the performances of the age, creatinine, and ejection fraction (ACEF) I and II scores and compare them with that of the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II score in patients…
View details →Tambaro FP, Fabozzi F, Masetti R et al. · 2026 · Frontiers in oncology
Deterioration of nutritional status in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is associated with increased morbidity. Enteral nutrition (EN) has been associated with more favorable outcomes than total…
View details →Higuchi T, Igarashi K, Miwa S et al. · 2025 · Medicine
The clinical utility of P-glycoprotein (P-gp) in osteosarcoma remains controversial. This retrospective cohort study aimed to investigate the association between P-gp expression and clinicopathological factors, chemotherapy (CTx) response,…
View details →Kim GH, Fass R · 2025 · Journal of neurogastroenterology and motility
Extraesophageal symptoms and signs of gastroesophageal reflux disease (GERD), such as throat clearing, globus sensation, hoarseness, cough, asthma, pulmonary fibrosis, otitis, sinusitis, and dental erosions, are common and pose diagnostic…
View details →Hirayama H, Ishida K, Kodama H et al. · 2026 · OTO open
Objective This study aimed to evaluate the benefits of recipient site of closed incision negative pressure therapy (ciNPT) on postoperative complications in head and neck reconstruction. Study design A single-center retrospective…
View details →Abbas AE, Kaneko T, Khalili H et al. · 2026 · Circulation. Cardiovascular interventions
Background Lower ( Methods Patients who underwent aortic valve-in-valve replacement with a balloon-expandable valve from July 2015 to December 2023 in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve…
View details →Prior D, Yang J, Nuño MM et al. · 2025 · Pediatric blood & cancer
Background Cisplatin, etoposide, and bleomycin (PEb) have been the standard of care for patients with germ cell tumors (GCT). In the 1990s, an intergroup trial (POG9049/CCG8882) randomized patients with high-risk GCT, as defined by the…
View details →Lavaire T, McLaughlin D, Liu S et al. · 2026 · Preprint
CoverCress is a new winter annual oilseed crop developed from field pennycress within the past 20 years. Field pennycress is commonly considered to be self-pollinated but little basic research has been published and there is some…
View details →Caneo M, Espinosa N, Aguilera A et al. · 2026 · Scientific reports
Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo-cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional…
View details →Mohamed M, Riad NM, Naeem S et al. · 2026 · Preprint
Abstract Background: Neonatal sepsis (NS) continues to be a leading cause of illness and death in newborns. The lack of identifiable clinical indications and inconclusive blood cultures highlights the need for non-invasive biomarkers that…
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