Negative / Null Result ReportMedicine
Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…
View details →Negative / Null Result ReportMedicine
Abrahams M, Bunting BP, Frewer LJ et al. · 2026 · Food & function
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small. Behaviour change theory implies the importance of goal setting to successful health intervention. This…
View details →Negative / Null Result ReportMedicine
Ben-Zeev T, Levi C, Ratamess NA et al. · 2026 · Hormones and behavior
This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were…
View details →Negative / Null Result Report
dela Cruz PC, Benson B, Jayavelu ND et al. · 2025 · Preprint
ABSTRACT Background Rhinovirus (RV) is the most common trigger of viral-induced pediatric asthma exacerbations. The impact of IL-13-driven inflammation, common in pediatric asthma, on airway epithelial antiviral and inflammatory responses…
View details →Negative / Null Result ReportMedicine
Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…
View details →Negative / Null Result ReportMedicine
Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
View details →Negative / Null Result Report
Lalunio H, Goodman CA, Stupka N et al. · 2026 · Preprint
Abstract Aims Chronic inflammation and oxidative stress are key components in Duchenne muscular dystrophy (DMD) pathology. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in…
View details →Negative / Null Result ReportMedicine
Wu J, Li G, Pen J et al. · 2026 · Journal of environmental management
Saline-alkali grassland ecosystems are essential methane (CH 4 ) sinks, playing a significant role in global CH 4 budgets. However, our understanding of the CH 4 uptake potential in saline-alkali grasslands and its response to climate…
View details →Negative / Null Result Report
Pirillo V, Barca F, Bruno D et al. · 2026 · Preprint
Insects offer promising opportunities for organic waste bioconversion; however, they cannot efficiently degrade synthetic polymers such as polyethylene terephthalate (PET). Here, we generated transgenic Drosophila melanogaster lines to…
View details →Negative / Null Result ReportMedicine
Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology
Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…
View details →Negative / Null Result Report
Nutter NA, Costa-Terryll A, Miller LM et al. · 2026 · Preprint
Streptococcus pneumoniae ( Spn ) asymptomatically colonizes the upper respiratory tract (URT), a niche from which it can transmit to another host or cause invasive disease in the same host. The in vivo transcriptional adaptations that Spn…
View details →Negative / Null Result ReportMedicine
Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →Negative / Null Result Report
Nicholas M, Ianssen M, Costa D et al. · 2026 · Preprint
Abstract Purpose Psychosocial factors have been identified as risks for delayed recovery after work injuries but results from interventions for high-risk cases have been mixed. An earlier Australian study that matched care to assessed…
View details →Negative / Null Result ReportMedicine
Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →Negative / Null Result ReportMedicine
Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
View details →Negative / Null Result ReportMedicine
Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →Negative / Null Result ReportOpen accessMedicine
Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →Negative / Null Result ReportOpen accessMedicine
Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
View details →Negative / Null Result ReportMedicine
Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →Negative / Null Result ReportMedicine
Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →Negative / Null Result ReportMedicine
Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →Negative / Null Result ReportMedicine
Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →Negative / Null Result ReportMedicine
Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →Negative / Null Result ReportMedicine
Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →Negative / Null Result ReportMedicine
Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education
Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…
View details →Negative / Null Result ReportMedicine
Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…
View details →Negative / Null Result Report
Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayón F · 2026 · Preprint
Abstract Rationale: Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive…
View details →Negative / Null Result ReportMedicine
Barris CT, Kress TC, Antonova G et al. · 2025 · American journal of physiology. Heart and circulatory physiology
The global rise in obesity parallels the increasing rates of hypertension and cardiovascular disease (CVD). These trends, and recent clinical and experimental data, have revealed that obesity abolishes the protection from CVD typically…
View details →Negative / Null Result ReportMedicine
Giri S, Wang X · 2026 · American journal of physiology. Heart and circulatory physiology
Neointimal hyperplasia (NH) is a prominent pathological consequence following vascular injury and is driven in part by aberrant vascular smooth muscle cell (VSMC) proliferation. COP9 signalosome (CSN) subunit 5 (CSN5/JAB1/COPS5) is the…
View details →Negative / Null Result ReportMedicine
de Sousa Fernandes MS, Kanashiro A, da Silva Fidélis DE et al. · 2026 · Scientific reports
Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox…
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