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Browse the failure-mode index

19,823 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

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Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

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Negative / Null Result ReportMedicine

<i>N</i>-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport.

Achilles S, Tomczak JN, Baumann FS et al. · 2025 · American journal of physiology. Gastrointestinal and liver physiology

DRA (Downregulated in adenoma, SLC26A3) is a major apical intestinal Cl - /HCO 3 - exchanger, which is expressed in complex and hybrid N -glycosylated forms. Although the importance of N -glycosylation is evident from the significantly…

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Negative / Null Result ReportMedicine

Body temperature and time perception in morning and evening types.

Erdoğan Ş, Tavat BC · 2025 · Physiology & behavior

Previous studies have suggested that time perception fluctuates throughout the day in relation to daily fluctuations of body temperature, and that there is a negative relationship between body temperature and time perception. The aim of…

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Negative / Null Result Report

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB

Necker-Brown A, Mostafa MM, Georgescu A et al. · 2025 · Preprint

Transcription factors of the interferon regulatory factor (IRF) family play key roles during viral and bacterial infections. However, IRF regulation by inflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor (TNF)…

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Negative / Null Result ReportMedicine

Comparison of Asynchronous Telepsychiatry vs Synchronous Telepsychiatry (CATELEST) in Skilled Nursing Facilities: A Randomized Controlled Noninferiority Clinical Trial.

Xiong GL, Iosif AM, Gonzalez AD et al. · 2025 · Journal of the American Medical Directors Association

Objective Comparison of asynchronous telepsychiatry (ATP) with traditional synchronous telepsychiatry (STP) in skilled nursing facilities (SNFs) in California, United States. Design Patient-level randomized, controlled noninferiority…

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Negative / Null Result ReportOpen accessMedicine

Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation.

Oliveira AHA, Paula DM, Serafini S et al. · 2026 · Acta cirurgica brasileira

Purpose To evaluate the effects of direct and remote ischemic preconditioning and postconditioning on kidney ischemia-reperfusion injury in young rats. Methods This study was divided into two experimental phases: preconditioning and…

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Negative / Null Result ReportOpen accessMedicine

Is there a difference in textbook outcomes of emergency cholecystectomy in older patients compared with younger patients?

Kesgin YM, Kaan AZ, Arslan M et al. · 2025 · World journal of emergency surgery : WJES

Background Textbook outcome (TO) is a concept that describes achieving an uneventful course for a patient undergoing surgery. It was first described for colorectal surgery and is now increasingly linked to various topics of surgical…

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Negative / Null Result ReportMedicine

Understanding caffeine's impact on sustained attention in early phase psychosis: Unveiling cognitive insights through the use of EEG.

Francis AM, Anderson TJ, McKearney KJ et al. · 2025 · Psychiatry research. Neuroimaging

Cognitive impairment, particularly in attention and working memory, is a notable feature of schizophrenia (SZ). Individuals with SZ frequently consume high levels of caffeine, often exceeding 550 mg daily, yet the cognitive effects of this…

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Negative / Null Result ReportMedicine

Quantitative analysis of 'virtual' SSP assessment clinics in the NHS bowel cancer screening programme in England.

Nickerson C, Wright S, Pickering L et al. · 2025 · Journal of public health (Oxford, England)

Background Bowel cancer screening in England is initially carried out using a home testing kit, with those who require further testing first being referred to an assessment clinic. During COVID-19, these assessment clinics became 'virtual'…

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Negative / Null Result ReportMedicine

The association between maternal diabetes, antidiabetic medication use, and severe ADHD requiring inpatient care: A registry-based cohort study.

Damtie Y, Betts K, Dachew BA et al. · 2025 · Journal of psychosomatic research

Background Limited evidence exists on the association between maternal use of antidiabetic medications and neurodevelopmental outcomes in children. This study examined the link between maternal diabetes, antidiabetic medication use, and…

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Negative / Null Result ReportMedicine

Neurocognitive passport: A novel feedback tool for pediatric patients with sickle cell disease.

Karst J, Miller M, Simpson P et al. · 2026 · Journal of child health care : for professionals working with children in the hospital and community

Sickle Cell Disease (SCD) is associated with neurocognitive impairment, and routine cognitive and academic screening is recommended. Traditional reports following testing are often not health literate, limiting the usefulness of…

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Negative / Null Result ReportOpen accessMedicine

Ocular Findings in Women with Cervical HPV Positivity and Cervical Dysplasia Undergoing Loop Electrosurgical Excision Procedure: A Prospective Cross-Sectional Study.

Vural NA, Mergen B, Güler S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : To evaluate ocular findings in women with cervical HPV positivity undergoing loop electrosurgical excision procedure (LEEP) for cervical dysplasia and to assess conjunctival/eyelid papilloma and other ocular…

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Negative / Null Result ReportMedicine

Impact of preoperative use of biologics on 30-day surgical morbidity and mortality in patients with Crohn's disease undergoing ileocolectomy: National Surgical Quality Improvement Program database analysis.

Daniel F, El Kouzi Z, Mrad J et al. · 2025 · Updates in surgery

Preoperative use of biologics has been inconsistently reported to be associated with increased frequency of infectious and surgical anastomotic complications in inflammatory bowel disease patients. We aimed to evaluate the rates of 30-day…

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Negative / Null Result ReportMedicine

Psychological mechanisms of change in reducing co-occurring social anxiety and alcohol use: A causal mediation analysis of the online Inroads intervention.

Gückel T, Prior K, Newton NC et al. · 2025 · Behaviour research and therapy

Background Research has documented the prevalence and treatment of co-occurring anxiety and alcohol use, but the mechanisms underlying treatment efficacy, especially in online interventions, remain unclear. This study investigated the…

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