Negative / Null Result ReportOpen accessPsychiatry
Junjun Liu, Junjun Liu, Junjun Liu et al. · 2023 · Frontiers in Psychiatry
ObjectiveTriglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naïve (FEDN) MDD.MethodsThis cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 ± 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Mul
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes et al. · 2019 · Immunity, Inflammation and Disease
Abstract Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied. We sought to investigate how the functionality of DENV–NS3 and DENV–NS5 protein‐specific T cells differ in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Methods Using intracellular cytokine assays, we assessed the production of interferon γ (IFNγ), tumor necrosis factor‐α (TNF‐α), macrophage inflammatory protein‐1β (MIP‐1β), a
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Pankaj Puar, Nikhil Mistry, Kim A. Connelly et al. · 2023 · ESC Heart Failure
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
View details →Negative / Null Result ReportOpen accessMedicine
Mina Niusha, Seyed Ali Rahmani, Leila Kohan et al. · 2023 · Asian Pacific Journal of Reproduction
Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Baravan Al-Kassou, Hasanin Al-Shaikh, Adem Aksoy et al. · 2023 · International Journal of Cardiology: Heart & Vasculature
Background: Vascular injury and bleeding complications remain frequent after transcatheter aortic valve replacement (TAVR). Whether the access-site of preprocedural coronary angiography (CAG) affects TAVR-related complications is not known. The aim of this study was to evaluate the impact of transradial (TRA) versus transfemoral access (TFA) for preprocedural CAG on outcomes in patients undergoing subsequent TAVR. Methods: The study cohort included 1002 patients undergoing transfemoral TAVR, of whom 39.4% (395/1002) had undergone radial and 60.6% (607/1002) femoral access for pre-TAVR CAG. The
View details →Negative / Null Result ReportOpen accessBusiness
Choudhury Mousumi, Singh Ranjit · 2016 · Acta Universitatis Sapientiae: Economics and Business
Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assuran
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology
Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Sonia Oveisi, Roghaye Keshavarz Sadegh, Sina Hosainzade et al. · 2025 · Discover Social Science and Health
Abstract Background Parenting self-efficacy (PSE) describes the beliefs and attitudes of parents on their capabilities to perform well on parenting tasks. Considering its direct relation to the physical and mental development of the children, we evaluated PSE in Iranian parents and investigated its potential effects on children's growth as a reflection of their self-regulation. Methods This investigation was conducted in 2019 in Takestan, Iran, and aimed to assess PSE in 300 parents of children under 2 years old. Families filled out a demographic questionnaire and a PSE questionnaire containin
View details →Negative / Null Result ReportOpen accessMedicine
Zainab Almussa · 2021 · The Medical Journal of Basrah University
Abstract: Introduction: Low birth weight is the best indicator of the impact in the health system and the best predictor of mortality and morbidity in the neonatal, post neonatal and childhood periods. Objectives: This study was planned to study the association between birth weight and selected risk factors in Basrah governorate with special reference to: Socio demographic factors, Present obstetric history, Past obstetric history, History of Ante Natal Care, and Medical history. Methods: This is hospital- based cross sectional study was conducted on 362 infants delivered and /or admitted to A
View details →Negative / Null Result ReportOpen accessDentistry
Patrícia Petromilli Nordi Sasso Garcia, Camila Pinelli, Juliana dos Reis Derceli et al. · 2015 · Brazilian Journal of Oral Sciences
Aim: This study assessed the risk factors of undergraduate students to develop musculoskeletal disorders (MSD) in the upper limbs, regarding gender, type of dental clinical procedure, mouth region treated, and the four-handed dentistry practice. Methods: Dental students enrolled in the 8th semester in the Araraquara School of Dentistry, UNESP, Brazil, were photographed while practicing 283 dental procedures. The Rapid Upper Limb Assessment (RULA) method was used to evaluate the working postures of each student. The photographs were evaluated and a final risk score was attributed to each analyz
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki et al. · 2002 · BMC Neurology
Abstract Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. Methods Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mansour S Almetwazi, Ahmad O Noor, Diena M Almasri et al. · 2017 · Saudi Pharmaceutical Journal
Objective: To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes. Research design and method: We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin
View details →Negative / Null Result ReportOpen accessMedicine
Xin Zhao, Chaoxuan Wang, Jian Wang et al. · 2026 · Scientific Reports
Abstract Sarcopenia, the progressive loss of muscle mass and function, is a significant health concern in middle-aged and older adults, potentially linked to adverse outcomes like falls and fractures. A cohort study was conducted utilizing participants aged ≥ 45 years from CHARLS. Sarcopenia was defined using established criteria. Primary outcomes were isolated falls, isolated hip fractures, and composite outcomes. Associations were assessed using multivariable Cox regression (adjusted for confounders), propensity score matching (PSM), and inverse probability weighting (IPW), reporting hazard
View details →Negative / Null Result ReportOpen accessPsychiatry
Ahmed Kamil Toman, Ahmed Kamil Toman, Ahmed Kamil Toman et al. · 2025 · Frontiers in Psychiatry
IntroductionCo-occurring conditions are common in children with autism spectrum disorder (ASD) and have important negative impacts on the children and their families. For Iraqi children, local healthcare systems tend to place more emphasis on the management of ASD itself while neglecting co-occurring conditions.ObjectivesThis study aims to investigate the prevalence, characteristics, and potential risk factors of co-occurring epilepsy, sleep, and weight issues among Iraqi children with ASD.MethodsA multicenter cross-sectional study was conducted from January 24 to August 7, 2024, including chi
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sharmin Chowdhury, Sheikh Joly Ferdous Ara, Shirazum Monira Mili et al. · 2022 · Advances in Cancer Biology - Metastasis
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world and incidences are on the rise in Bangladesh. KRAS, NRAS, BRAF, PIK3CA, and AKTI gene mutations are predictive markers of biological therapies, monoclonal antibodies targeting EGFR. The purpose of this study was to detect KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes mutation in CRC patients by multiplex real-time Polymerase Chain Reaction (PCR) and evaluate the association of the mutations with clinicopathological features. Methodology: This cross-sectional study was carried out in the Department of Microbiology &
View details →Negative / Null Result ReportMedicine
H. Henjum, Karoline Mo Feten, Erlend Hartvigsen et al. · 2025 · Acta oncologica
Background and purpose Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure to healthy tissues compared to conventional Intensity-Modulated Proton Therapy (IMPT) with…
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Sanjay B Tripathi, Vishakha K Kapadia · 2015 · National Journal of Community Medicine
Objectives: To evaluate the clinical profile and the factors influencing treatment outcome of TB patients co-infected with HIV attending DOT centers of Southeast area of Ahmedabad, Gujarat Methodology: A Prospective observation study was conducted to assess the treatment outcome of TB in TB-HIV co-infected patients on DOTs conducted at L.G. Hospital and tuberculosis units (TUs) of south and east region of Ahmedabad. TB patients started DOTS were registered and were followed till treatment outcome was declared. Results: The treatment success rate was found to be 84.17% (101 of 120 patients). Tr
View details →Negative / Null Result ReportOpen accessMedicine
Artha Falentin Putri Susilo, Hanom Husni Syam, Hartanto Bayuaji et al. · 2024 · Scientific Reports
Abstract Vitamin D and calcium in follicular fluid play an important role in modulating steroidogenesis, folliculogenesis, and oocyte quality determination. Both collaborate to produce top-quality embryos (TQE) during in vitro fertilization (IVF). In this study, we compared free 25(OH)D3 and calcium levels in follicular fluid between TQE and non-TQE groups. This cross-sectional study included women who underwent IVF procedures at tertiary hospitals in Bandung, Indonesia. Ovarian follicular fluid was collected during the ovum pick-up procedure. The examination of 25(OH)D3 levels, vitamin d-bind
View details →Negative / Null Result ReportOpen accessMedicine
Sarah Moreira de Sousa Gomes, Paulo César Apolinário de Souza, Cassiane Freitas Rodrigues et al. · 2026 · DST
Introduction: Women living with HIV/AIDS (WLHA) are more vulnerable to human papillomavirus (HPV) infection, particularly by high-risk oncogenic subtypes, due to HIV-associated immunosuppression. Objective: To assess the prevalence and distribution profile of HPV subtypes in WLHA, correlating findings with CD4 levels and age group. Methods: A cross-sectional study was conducted with 184 WLHA receiving care at a public referral center in Juiz de Fora, Minas Gerais, from May 2021 to May 2022. Self-collected vaginal samples were analyzed by RT-PCR to detect HPV subtypes. Associations between HPV
View details →Negative / Null Result ReportOpen accessGeriatrics
Socheat Cheng, Tahreem Ghazal Siddiqui, Michael Gossop et al. · 2020 · BMC Geriatrics
Abstract Background Central nervous system depressant medications (CNSDs) such as opioid analgesics and sedative-hypnotics are commonly prescribed to older patients for the treatment of chronic pain, anxiety and insomnia. Yet, while many studies reported potential harms, it remains unknown whether persistent use of these medications is beneficial for older patients’ self-reported health-related quality of life (HRQoL). The present study clarified this knowledge gap through comparing HRQoL of hospitalized older patients with versus without using CNSD drugs for ≥4 weeks. Moreover, we explored th
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Karthikeyan R, Marimuthu G, Ramasubramanian C et al. · 2014 · Neuropsychiatric Disease and Treatment
Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India; 2MS Chellamuthu Trust and Research Foundation, KK Nagar, Madurai, India; 3University Sleep Disorders Center, College of Medicine, National Plan for Science and Technology, King Saud University, Riyadh, Saudi Arabia; 4Independent researcher, Toronto, Ontario, C
View details →Negative / Null Result ReportOpen access
Padma B Prabha, Jyothi P T · 2022 · Journal of Education Technology in Health Sciences
Structured interactive lectures (SIL) and Flipped classroom methods (FCM) are newer teaching learning methods which utilise pedagogical way of teaching. This study intends to compare efficacy of both methods in the understanding of…
View details →Negative / Null Result ReportOpen accessMedicine
Nihal Al Riyami, Intisar Al-Ruheili, Fatma Al-Shezawi et al. · 2013 · Oman Medical Journal
Objectives: Preterm premature rupture of membranes (PPROM) is defined as a rupture of the amniotic membranes occurring before 37 weeks of gestation and before the onset of labor. Extreme PPROM occurs prior to 26 weeks gestation and contributes to an increased risk of prematurity, leading to maternal and fetal complications. This study aims to estimate the risk factors associated with various maternal complications and to determine the worst outcomes in Omani females with extreme PPROM.Methods: A retrospective cohort study was conducted on 44 women with extreme PPROM, who delivered at Sultan Qa
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Jaehyung Lee, Janghyun Kim, Sungkuk Chae et al. · 2024 · Foot & Ankle Orthopaedics
Category: Diabetes; Other Introduction/Purpose: Foot ulcers and subsequent amputations are disabling complications in diabetic patients, and major amputations, including below-knee amputations, leave patients with catastrophic disabilities. Diabetes is the most common cause of causing end-stage renal disease which results in hemodialysis, and patients with diabetes on hemodialysis have a higher prevalence of several co-morbidities compared to those without diabetes. The purpose of this study is to compare survival rates after below knee amputation in patients with diabetes who are on hemodialy
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Ko Yoon, Won Hye, Jeon Eun et al. · 2011 · BMC Cancer
Abstract Background CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various cancers. In the present study, we sought to determine whether CD44s is involved in clinical outcomes of patients with resected non-small cell lung cancer (NSCLC). Methods Using immunohistochemical staining, we investigated CD44s protein expression using tissue array specimens from 159 patients with resected NSCLC (adenocarcinoma (AC; n = 82) and squamous cell carcinoma (
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Siqi Luo, Bingquan Xiong, Yuling Chen et al. · 2026 · Critical Public Health
Engagement in physical activity (PA) is a key health-promoting behavior in the prevention and management of chronic kidney disease (CKD). However, evidence regarding the associations between domain-specific PA and CKD remains limited. This study examined the relationships between different PA domains and CKD. Data were obtained from a large population-based survey. PA was self-reported and categorized into transportation-related (TPA), occupational (OPA), and leisure-time PA (LTPA). Multivariable logistic regression, restricted cubic spline models, and subgroup analyses were used to assess ass
View details →Negative / Null Result ReportOpen accessMedicine
Dana S Forcey, Jane S Hocking, Sepehr N Tabrizi et al. · 2014 · PLoS ONE
BACKGROUND: We investigated the detection of chlamydia at different stages of the menstrual cycle. METHODS: Electronic medical records for women attending Melbourne Sexual Health Centre between March 2011 and 31(st) December 2012, who were tested for chlamydia by nucleic acid amplification of high vaginal, cervical, or urinary samples, and who recorded a date of last normal menstrual period (LNMP) between 0-28 days were included in the analysis. Logistic regression was used to calculate adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the association of chlamydia with menstrual
View details →Negative / Null Result ReportOpen accessOther systems of medicine
Nuha Shawarb, Manal Badrasawi, Hassan Abu Qaoud et al. · 2023 · BMC Complementary Medicine and Therapies
Abstract Background The medicinal application of natural plant remedies is well established. These medicinal plants are still in use within the Palestinian community to treat several illnesses. This research is intended to study the use of natural plants to treat different types of respiratory tract disorders. Method This ethno botanical study focused on the medicinal plants that are used to treat respiratory diseases in the northern part of Palestine; Nablus, Tulkarm, Qalqilia, and Jenin. A questionnaire was distributed to 120 respondents. The data obtained included names of the plants used,
View details →Negative / Null Result ReportOpen accessMedicine
Liugang Xu, Yajun Wang, Hongyun Ji et al. · 2024 · PLoS ONE
Background Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causal relationship between the frailty index (FI), and both systemic atherosclerosis and lipids. Methods We obtained summary statistics from large-scale genome-wide association studies (GWAS) of various phenotypes, including frailty (n = 175,226), coronary atherosclerosis (n =
View details →Negative / Null Result ReportOpen accessVeterinary medicine
K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak · 2006 · Veterinární Medicína
The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month
View details →