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19,821 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessSurgery

Is Anti-platelet Treatment Necessary for Penile Mondor’s Disease?

Ahmet Murat Bayraktar, Muhammet İrfan Dönmez · 2019 · Journal of Urological Surgery

Objective:The aim of this study was to determine if anti-platelet treatment would have any effect on the rate and duration of resolution in penile Mondor’s disease.Materials and Methods:A retrospective review of patients diagnosed with Mondor’s disease between 2014 and 2018 was conducted. The patients were divided into two groups with regard to anti-platelet treatment. Age, initial symptom, medications [short-term fluoroquinolone antibiotics (Ab) ± low-dose acetyl salicylic acid (ASA)], and erectile function scores were evaluated. Moreover, ultrasonographic findings (location and length of thr

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Negative / Null Result ReportOpen accessOphthalmology

Efficacy of two vertically integrated teaching–learning methods – The ocular basic science workshop versus lecture in enhancing knowledge and skills of ocular examination techniques and underlying principles in second clinical year medical students: A prospective interventional study

Anika Amritanand, Danica Lyngwa, Nimmy Thomas et al. · 2021 · TNOA Journal of Ophthalmic Science and Research

Purpose: The purpose of the study was to compare the efficacy of two vertically integrated teaching–learning methods, a peer-led ocular basic science workshop (OBSW) versus lecture by ophthalmology faculty, in enhancing the underlying basic science knowledge and examination skills of ophthalmic clinical tests among second clinical year medical students. Design: This was a prospective, interventional comparative study. Students were randomly assigned to peer-led OBSW and interactive lecture-based method of teaching by a faculty. Change in knowledge was assessed using pre and post multiple-choic

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Negative / Null Result ReportOpen accessMedicine

Mortality and Functional Outcomes of Liberal versus Restrictive Blood Transfusion in Elderly Patients after Hip Surgery: A Randomised Control Trial.

Patil VE, Barick D, Degloorkar P et al. · 2026 · Hip & pelvis

Purpose There is ongoing debate on the haemoglobin level at which red cell transfusion should be administered following surgery. This study aimed to evaluate the benefits of a restrictive blood transfusion strategy and assess potential…

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Negative / Null Result ReportOpen accessMedicine

Sequential therapy versus quadruple therapy for Helicobacter pylori eradication: A prospective double‐blinded randomized controlled trial

Elham Tabesh, Farzad Yadmehr, Awat Feizi et al. · 2024 · Health Science Reports

Abstract Backgrounds and Aims This controlled randomized clinical trial was designed to compare effectiveness, side effects, and severity of symptoms before and after therapy between quadruple (QT) and sequential regimens (SQ) for Helicobacter Pylori (H. pylori). Methods Patients were randomly allocated into two groups. Group A received a 14‐day QT including pantoprazole 40 mg q12 h, bismuth subcitrate 240 mg q12 h, clarithromycin 500 mg q12 h, and amoxicillin 1000 mg q12 h and group B received ST including pantoprazole 40 mg q12 h and amoxicillin 1000 mg q12 h for the initial 5 days followed

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Negative / Null Result ReportOpen accessAstrophysics

Evidence for Dynamical Filtering: High Binary Fraction, Hard-binary Excess, and Unresolved Triples in the Surviving Core of NGC 6791

Huanbin Chi, Zhi Li, Feng Wang et al. · 2026 · The Astrophysical Journal

We present a deep photometric analysis of the main-sequence (MS) population in the old, metal-rich open cluster (OC) NGC 6791 using Gaia Data Release 3 data. After correcting for differential reddening, we use the Bayesian model comparison to test whether stellar rotation can account for the observed MS broadening and find that a rotation-dominated interpretation is strongly disfavored. We therefore infer that unresolved multiplicity is the primary contributor to the photometric offsets. We derive a high- q companion fraction of 54.3% ± 2.8% for systems with q ≳ 0.5, significantly higher than

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Negative / Null Result ReportOpen accessMedicine

EVALUATION OF THE EFFECT OF MODE OF DELIVERY ON HEMATOLOGICAL PARAMETERS OF HEALTHY FULL-TERM NEWBORNS

Subh Salem Al-Mudallal, Muna Abd Al-Moeen Al- Habbobi · 2016 · The Iraqi Journal of Medical Sciences

Background: Hematological values at birth encompass broader ranges of normal than at any other time in life, and despite advances in perinatology over the past years, the exact influence of perinatal factors on hematological values in cord blood in normal pregnancy is still unclear. Moreover there was a wide variation and overlap in values between normal and abnormal infants with early symptoms and signs of neonatal sepsis. Objectives: 1. To obtain the values of hematological parameters including complete blood picture, red cell indices, nucleated red blood cells and reticulocyte count in heal

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Negative / Null Result ReportOpen accessGeriatrics

The Seniors’ Community Hub: An Integrated Model of Care for the Identification and Management of Frailty in Primary Care

Marjan Abbasi, Sheny Khera, Julia Dabravolskaj et al. · 2021 · Geriatrics

(1) Background: Integrated models of primary care deliver the comprehensive and preventative approach needed to identify and manage frailty in older people. Seniors’ Community Hub (SCH) was developed to deliver person-centered, evidence-informed, coordinated, and integrated care services to older community dwelling adults living with frailty. This paper aims to describe the SCH model, and to present patient-oriented results of the pilot. (2) Methods: SCH was piloted in an academic clinic with six family physicians. Eligible patients were community dwelling, 65 years of age and older, and consi

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Negative / Null Result ReportOpen accessSpecialties of internal medicine

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Anina F. van de Koolwijk, Thijs S.R. Delnoij, Martje M. Suverein et al. · 2024 · Resuscitation Plus

Background: Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional CPR (CCPR) are scarce. We aimed to determine HRQoL during 1-year after refractory OHCA in patients treated with ECPR and CCPR. Methods: We present a secondary analysis of the multicenter INCEPTION-trial, which studied the effectiveness of ECPR versus CCPR in patients with refractory OHCA. HRQoL was prospectively assessed using the EQ-5D-5L questionnaire. Poor HRQoL was p

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Negative / Null Result ReportOpen accessNursing

Clinical effect of venousaccess ports and PICC in patients with tumor chemotherapy:a systematic evaluation

孔德华, 张蕾, 储静 · 2018 · Huli yanjiu

Abstract Objective:To systematically review the clinical effect of venousaccess ports(VPA/VAP)and peripheral venous catheterization(PICC)in patients with tumor chemotherapy.Methods:Randomized controlled trial(RCT),semirandomized controlled trial,and cohort study of comparison the application effect of VAP and PICC in patients with tumor chemotherapy were retrieved from the Cochrane CDSR,PubMed,Embase,CINAHL,SCIE,Chinese biomedical literatures service system(CBM),Wanfang,and VIP database.According to the inclusion criteria,two researchers selected the literature,extracted the data,and evaluated

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Negative / Null Result ReportOpen accessPediatrics

The Effect of Plastic Cover on Regulation of Vital Signs in Preterm Infants: A Randomized Cross-over Clinical Trial

Leila Valizadeh, Majid Mahallei, Abdolrasoul Safaiyan et al. · 2017 · Iranian Journal of Neonatology

Background: Considering the susceptibility of preterm infants to disturbances of vital signs, this study was conducted to investigate the effects of using plastic covers on regulation of vital signs in preterm neonates.Methods: This randomized, cross-over, clinical trial was carried out on 80 preterm infants admitted to neonatal intensive care unit (NICU) of Taleghani Hospital, Tabriz, Iran. The study was conducted in two days (on the second and third days of the infants’ life). In group 1, plastic cover was used during the first day followed by the use of blanket on the second day, while the

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Negative / Null Result ReportOpen accessEducation

استراتيجية التحفيز المتکامل وعلاقتها بخفض اضطرابات اللغة الاستقبالية لدى أطفال اضطراب طيف التوحد Integrated stimulation strategy and its relationship to reducing receptive language disorders in children with autism spectrum disorder

أ.م.د/ أسماء فتحي احمد, أ.د/ سلوى عبد السلام عبد الغنى, أحمد صلاح طه قطب · 2022 · مجلة التربیة وثقافة الطفل

Abstract: The study aimed to identify the extent of the contribution of the integrated stimulation strategy in reducing receptive language disorder among children with autism spectrum disorder , and the study sample consisted of (5) children (3 males, 2 females) of autism spectrum disorder children, ranging in age from The time period ranged between (5:6) years at the Al-Nour Center for Communication and Training in Minia Governorate, and the homogeneity of the study sample was taken into account, in terms of: age and intelligence level. The researcher used both the Gilliam Scale to diagnose A

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Negative / Null Result ReportOpen accessDentistry

Evaluation of hardness and wear resistance of interim restorative materials

Omid Savabi, Farahnaz Nejatidanesh, Mohamad Hossein Fathi et al. · 2013 · Dental Research Journal

Background: The interim restorative materials should have certain mechanical properties to withstand in oral cavity. The aim of this study was to evaluate the hardness and wear resistance of interim restorative materials. Materials and Methods: Fifteen identical rectangular shape specimens with dimensions of 2 mm × 10 mm × 30 mm were made from 7 interim materials (TempSpan, Protemp 3 Garant, Revotek, Unifast LC, Tempron, Duralay, and Acropars). The Vickers hardness and abrasive wear of specimens were tested in dry conditions and after 1 week storage in artificial saliva. The depth of wear was

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Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Coronary Periarteritis and Pericardial Thickening Could Be Predictors for Coronary Artery Events Complicated by IgG4-Related Disease

Hiroki Yagi, MD, PhD, Eisuke Amiya, MD, PhD, Masae Uehara, MD, PhD et al. · 2023 · CJC Open

Background: IgG4-related disease (IgG4-RD) is a systemic disease characterized by serum IgG4 upregulation, massive infiltration of IgG4-positive plasma cells, and storiform fibrosis, which results in nodules or thickening of the involved organs. Cardiologists have recently recognized that IgG4-RD can be complicated by coronary artery events (CAEs); however, the mechanisms and clinical characteristics of this phenomenon are unknown. We evaluated the clinical signs of patients with coronary periarteritis (CP), aortic periarteritis (AP), and pericardial thickening, which are complications of IgG4

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Negative / Null Result ReportOpen accessSpecial aspects of education

أثر برنامج إرشادي تدريبي في تنمية الاعتزاز بالهوية الوطنية والشعور بالانتماء لدى الطالب المعلم تخصص صعوبات التعلم في ضوء رؤية المملکة العربية السعودية (2030) بحث مقدم لمشروع باحث (6) برقم (FR6-96)جهة التمويل: عمادة البحث العلمي بجامعة جازان The impact of Training Counseling Program in The Development of Pride

عبده مسملى, الدود أحمد, سلطان کليبى · 2019 · مجلة التربیة الخاصة والتأهیل

أُجري هذا البحث في العام (2019-2018)، هدف إلى الکشف عن أثر برنامج إرشادي تدريبي في تنمية الاعتزاز بالهوية الوطنية والشعور بالانتماء لدى الطالب المعلم تخصص صعوبات التعلم في ضوء رؤية المملکة العربية السعودية (2030). استخدمت الباحثان المنهج التجريبي، تکون مجتمع البحث من (220) طالبًا معلمًا بقسم التربية الخاصة. اشتملت عينة البحث على (26) طالبًا معلمًا، تضمنت مجموعتين، تجريبية (13) طالبًا معلمًا، وضابطة (13) طالبًا معلمًا، تم اختيارها بالطريقة العشوائية البسيطة. استخدم الباحثون مقياسي الاعتزاز بالهوية الوطنية، والذي تکون من(62) عبارة، ومقياس الشعور بالانتماء، والذي تکون من(69) عبارة. ولتحليل البيان

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Negative / Null Result ReportOpen accessDentistry

Effect of adhesive type and silane application on the repair bond strength of aged bulk-fill composites

Atefeh Yousefi Jordehi, Saeed Abdollahi, Ghazal Golshahirad et al. · 2025 · Journal of Dental Materials and Techniques

Objective: This study evaluated the effects of different adhesive strategies and silane application on the repair bond strength of bulk-fill composites.Methods: Seventy specimens were prepared using a bulk-fill condensable composite. After thermocycling, they were randomly divided into five groups (n = 14) based on the bonding protocol: Group 1: Gluma Bond 5 (two-step etch-and-rinse), Group 2: Silane + Gluma Bond 5, Group 3: Gluma Bond Universal (self-etch mode), Group 4: Silane + Gluma Bond Universal (self-etch mode), and Group 5: Gluma Bond Universal (etch-and-rinse mode). The repair process

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Negative / Null Result ReportOpen accessMedicine

Correction of Coronal Deformities in Pediatric Knees : Guided Growth by 8 plate Versus Corrective Osteotomy

Elsayed Said, Khaled H. Mosallam, Abdelrahman MK Maala* et al. · 2023 · SVU - International Journal of Medical Sciences

Background: Coronal deformities around the knee are most commonly presented in paediatric orthopaedic. Physiological deformities are most often managed conservatively, but severe deformities that cause pain and dysfunction require surgical intervention with acute correction (osteotomy), or gradually by hemiepiphyseodesis. Objectives: The main objective of this prospective study is to assess and compare short term results following correction by osteotomy versus 8-plate hemiepiphyseodesis. Patients and Methods: 30 skeletally immature patient, aged (3-14 years); presented with angular deformitie

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Negative / Null Result ReportOpen accessEducation

فاعلية برنامج قائم على استراتيجية المجموعات المرنة لتنمية مهارتي التحرک البصري والعلاقات البصرية لدى الأطفال ذوي القصور الفکري القابلين للتعلم The Effectiveness of a Program based on Flexible Group Strategy for Developing Visual Movement and Visual Relations skills of Learnable Children with Intellectual Disabilities

أ.م.د/ وفاء رشاء راوي, إعداد: أ/ شيماء محمود عبد الحکيم, إشراف: أ.د/ نبيل السيد حسن · 2021 · مجلة التربیة وثقافة الطفل

Abstract: The current research aimed at identifying the effectiveness of flexible group strategy for developing visual movement and visual relations skills of learnable children with intellectual disabilities. The researchers utilized the experimental research approach of one experimental group design with pre-, post-, and follow-up measurements. The research sample comprised (12) male and female learnable children with intellectual disabilities whose ages ranged between (6: 11) years. The research tools included the Stanford Binet intelligence scale (5th ed.) and the visual discrimination ski

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Negative / Null Result ReportOpen accessDentistry

Relationship between the Apical Preparation Diameter and the Apical Seal: An In Vitro Study

Kaoutar Laslami, Sara Dhoum, Amine El Harchi et al. · 2018 · International Journal of Dentistry

Objectives. The aim of the study is to define the relationship between the apical preparation diameter and the apical sealing ability to highlight the importance of the preservation of the diameter and the original position of the apical foramen. Materials and Methods. 50 extracted maxillary incisors were randomly allocated into three groups of 15 teeth each (n = 15) according to the apical preparation size: Group 1: finishing file F1 corresponding to size 20 reached the working length (ProTaper Universal system Dentsply®); Group 2: prepared up to size 30 corresponding to finishing file F30; G

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Negative / Null Result ReportOpen accessMedicine

High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study

Bruna Cassia Dal Vesco, Ana Carolina de Miranda, Fernanda do Carmo De Stefani et al. · 2026 · Einstein (São Paulo)

ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed to investigate whether peripheral hypoperfusion in septic patients is associated with serum levels of damage-associated molecular patterns. Methods: A retrospective cohort study was conducted to compare serum levels of damage-associated molecular patterns - histone H3, histone H4, and high-mobility group box-1 protein (HMGB1) - with markers of tissue hypoperfusion - the peripheral perfusion index and the capillary refill time, using a single measuremen

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Negative / Null Result ReportOpen accessPublic aspects of medicine

‘Saga Stories in health talks’ for health promotion in Swedish child healthcare: results from a cluster-randomised hybrid type 1 effectiveness-implementation study

Maria Henström, Christine Delisle Nyström, Susanne Andermo et al. · 2025 · BMC Public Health

Abstract Background Early-life interventions are essential for improving public health since lifestyle behaviours are established already in childhood. Child healthcare (CHC) plays a crucial role in this context. The ‘Saga Stories in health talk’ (SSiHT) material includes a flipchart with colourful illustrations to facilitate CHC nurses’ routine health talks with parents and their children, and a hand-out material kit to support healthy lifestyle behaviours in the families. Our aim was to evaluate the effectiveness of the SSiHT intervention at the 5-year routine visit at CHC on parental self-e

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Negative / Null Result ReportOpen accessPhilology. Linguistics

Avaliação das habilidades auditivas em crianças com alterações de aprendizagem Evaluating auditory abilities in children with learning disabilities

Tatiane Maria Pelitero, Alessandra Kerli da Silva Manfredi, Andrea Pires Corrêa Schneck · 2010 · Revista CEFAC

OBJETIVO: comparar o desempenho na Avaliação Simplificada do Processamento Auditivo (ASPA) e no Pediatric Speech Intelligibility Test (PSI), de crianças com alteração de Aprendizagem da Leitura e Escrita e sem este tipo de alteração. MÉTODOS: participaram da pesquisa 28 crianças na faixa etária de 8 a 12 anos, do sexo masculino e feminino. Os participantes foram submetidos ao Teste de Desempenho Escolar (TDE) para a categorização dos grupos de estudo e controle, e, para avaliação das habilidades auditivas foram aplicados a ASPA e o Teste PSI. RESULTADOS: não foi observada associação estatistic

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Negative / Null Result ReportOpen accessMedicine (General)

Evaluation of the non-invasive indicators in predicting detrusor underactivity in individuals with small-volume prostatic hyperplasia and lower urinary tract symptoms

Yanyuan Wu, Yedie He, Jun Qi et al. · 2024 · Journal of Men's Health

This study was aimed to retrospectively analyze the potential of non-invasive serum biomarkers in clinically predicting the detrusor underactivity (DU) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) and low prostate volume (PV). The study enrolled 196 patients with BPH and LUTS at our hospital in the period from January 2018 to October 2023. The patients were divided into two groups based on the projected isovolumetric pressure (PIP): the DU and the control groups. The patients included in the study had PV of less than 50 mL. A total of 93 and 103 cases

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Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment

Zhaoying Li, Shanyu Liu, Yuling Shen et al. · 2025 · Frontiers in Neuroscience

BackgroundAbnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI patients into distinct subgroups, aiming to clarify the neural mechanisms underlying their cognitive profiles.MethodsParticipants included aMCI patients categorized into the turbid phlegm clouding the orifices (PCO) or spleen-kidney deficiency (SKD) syndrome subgroups, alongside co

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Negative / Null Result ReportOpen accessMedicine

Comparative analysis on arthroscopic sutures of large and extensive rotator cuff injuries in relation to the degree of osteopenia

Alexandre Almeida, Vinícius Atti, Daniel Cecconi Agostini et al. · 2015 · Revista Brasileira de Ortopedia

OBJECTIVE: To analyze the results from arthroscopic suturing of large and extensive rotator cuff injuries, according to the patient's degree of osteopenia.METHOD: 138 patients who underwent arthroscopic suturing of large and extensive rotator cuff injuries between 2003 and 2011 were analyzed. Those operated from October 2008 onwards formed a prospective cohort, while the remainder formed a retrospective cohort. Also from October 2008 onwards, bone densitometry evaluation was requested at the time of the surgical treatment. For the patients operated before this date, densitometry examinations p

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Negative / Null Result ReportOpen accessMedicine (General)

Optimising after-hours workflow of computed tomography orders in the emergency department

Joseph Choi, Rajesh Bhayana, Chenhan D Wang et al. · 2020 · BMJ Open Quality

Ordering and protocolling CT scans after-hours from the emergency department (ED) at our institution previously required discussion between the ED physician and radiology resident, which led to workflow inefficiency. Our intervention consisted of creating an electronic list of CT requests that radiology residents would monitor. Radiology protocolled straightforward requests and contacted the ordering physician for more details when required. We aimed to improve workflow efficiency, increase provider satisfaction and reduce CT turnaround time without significantly affecting CT utilisation. Plan

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Negative / Null Result ReportOpen accessMedicine

Comparison of Long-Term Outcomes of Postmastectomy Radiotherapy between Breast Cancer Patients with and without Immediate Flap Reconstruction.

Hsin-Hua Lee, Ming-Feng Hou, Shu-Yi Wei et al. · 2016 · PLoS ONE

To compare the long-term clinical outcomes of postmastectomy radiotherapy (PMRT) between breast cancer patients with and without immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction.The study included 492 patients with stage II or III breast cancer who underwent modified radical mastectomy (MRM) and chemotherapy followed by PMRT between 1997 and 2011. Cox regression model and Kaplan-Meier curves were calculated, and the log-rank test was used to evaluate the differences between overall and disease-free survival rates in the 2 groups.Among 492 patients, 213 patients had

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Negative / Null Result ReportOpen accessMedicine

Tooth discoloration caused by nanographene oxide as an irrigant and intracanal medicament in the endodontic treatment of extracted single-rooted teeth: An ex-vivo study.

Abbas Abbaszadegan, Zeinab Rafiee, Bahar Asheghi et al. · 2025 · PLoS ONE

Tooth discoloration caused by intracanal medicaments and irrigants presents a significant aesthetic challenge in dentistry. This study aimed to investigate the discoloration effects on tooth of nanographene oxide and positively charged silver nanoparticles and compares them with other commonly used materials in endodontic treatment. A total of 108 single-rooted, single-canal anterior mandibular and maxillary premolar teeth, extracted for orthodontic or periodontal reasons, were selected and prepared. The specimens were randomly divided into seven experimental groups and two control groups, eac

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Negative / Null Result ReportOpen accessMedicine (General)

Understanding Anastomotic Healing in Colo-Rectal Surgery; a Multicentric 5-Year Analysis of Predictive Factors for Integrity and Fistula Formation

Dumitru-Dragos Chitca, Octavian Mihalache, Florin Bobircă et al. · 2026 · Diagnostics

Background : Anastomotic leakage (AL) remains one of the most feared complications after colorectal surgery. This study aimed to identify preoperative risk factors for AL using a five-year dataset from two Romanian surgical clinics. Materials and Methods : A retrospective cohort of 155 patients undergoing colorectal resection with primary anastomosis (105 from “Colentina” Hospital and 50 from “Dr. I. Cantacuzino” Hospital) was analyzed. Preoperative demographic, clinical, and laboratory data were extracted and assessed using univariate and multivariable logistic regression. Statistical analyse

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Negative / Null Result ReportOpen accessMedicine

Comparison of Bilateral and Unilateral Applications of Percutaneous Vertebroplasty and Kyphoplasty Procedures.

Serpi M, Çakan A, Akpınar A · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Vertebral fractures result from degenerative, osteoporotic, or traumatic spinal loading. Treatment options include conservative management, segmental fusion, and percutaneous vertebroplasty/kyphoplasty (PVP/BKP) performed using…

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