19,820 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics
Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…
View details →Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders
Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…
View details →Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports
A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…
View details →Dong, Patel, Wang et al. · 2026 · Environment international
Phthalates are pervasive endocrine-disrupting chemicals widely used in consumer products. The wide use of many phthalates results in chronic human exposure to complex mixtures rather than single compounds. Despite extensive studies on…
View details →Malzahn, Höft Budde, Kneißl et al. · 2026 · Innere Medizin (Heidelberg, Germany)
The German healthcare system, despite its high performance, fails to achieve the goal of needs-based service provision. Supply-induced demand, regional disparities and misaligned financial incentives lead to overuse, underuse and misuse of…
View details →Shigemoto, Kim · 2026 · Psychology, health & medicine
Chronic pain among people of color is influenced by biological, structural, and social forces. While network models have been applied to chronic pain symptoms, research on resource disparities often isolates factors such as income, failing…
View details →Thiede, Haris, Damjanović et al. · 2026 · Journal of mass spectrometry : JMS
In conventional native mass spectrometry (MS), one faces severe limitations when challenged with heterogeneous, high-mass samples, commonly failing to resolve clear peak distributions, and thus mass determination. Charge detection MS…
View details →Taylor, Roberts, Rayner · 2026 · Viruses
Chikungunya virus (CHIKV) is an alphavirus that infects dermal fibroblasts as a primary target cell during natural mosquito-borne transmission. While primary human dermal fibroblasts (hDFs) have been implicated as a key source of type I…
View details →Canton, Ceballos, Canton et al. · 2026 · Pharmaceutics
Background/Objectives: Combination of antiparasitic drugs with different mechanisms of action has been suggested as an effective strategy to delay the development of parasite resistance. Considering the need to understand the…
View details →Perez Arteaga, Yeh · 2026 · Nutrients
Surgical trauma triggers a complex metabolic and inflammatory response that can profoundly affect patient recovery and clinical outcomes. The magnitude of this stress response correlates with surgical complexity, patient comorbidities, and…
View details →Tan, Lye, Patel et al. · 2026 · International journal of molecular sciences
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this…
View details →Ullah, Li, Aljasir et al. · 2026 · Life (Basel, Switzerland)
Background : Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with limited treatment options. Tumors harboring the BRAF V600E mutation exhibit aggressive behavior and present therapeutic challenges. Although…
View details →Kuchana, Repalle, Alahari et al. · 2026 · Cancers
Artificial intelligence (AI) is reshaping oncology at every stage of the cancer care pathway, from population-level screening through molecular diagnosis, treatment planning, and post-treatment surveillance. Despite an exponential growth…
View details →Jiang, Qi, Ma et al. · 2026 · Veterinary research
Feline calicivirus (FCV) evolves rapidly under immune pressure, yet the genetic basis of antigenic escape remains poorly understood, particularly when sequence divergence is limited. We isolated 13 FCV strains from cats in Jilin Province,…
View details →Liu, Su, Gong et al. · 2026 · BMC infectious diseases
Chlamydia abortus primarily causes abortion and stillbirth in animals and is associated with pregnancy-related complications in humans. However, it is an extremely rare cause of pneumonia in humans. While Chlamydia psittaci is a…
View details →Faurholt-Jepsen, Hammershøi, Bruun et al. · 2026 · Journal of affective disorders
Distinguishing between bipolar disorder type I and II constitutes a significant clinical challenge that relies on retrospective patient recall. Misclassification carries risks of inappropriate pharmacological management. Digital…
View details →He, Lin, Zhang et al. · 2026 · Diabetes research and clinical practice
Cardiovascular-kidney-metabolic (CKM) syndrome defines a pathophysiological continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Stages 0-3 represent a critical subclinical window for…
View details →Romero-Alfano, Prats, Raldúa et al. · 2026 · The Science of the total environment
Mixture toxicity studies on neuroactive chemicals remain scarce and often rely on simplified combinations of compounds with known modes of action (MoA), despite the frequent non-monotonicity of neuroactive responses. Furthermore, real…
View details →Lin, Li, Cheng et al. · 2026 · Briefings in bioinformatics
Current metabolomics approaches predominantly rely on group-level differential abundance screening. While effective for identifying biomarkers, this paradigm often overlooks upstream regulatory hubs and fails to resolve the…
View details →Oduncu, Zor, Çimen et al. · 2026 · Forensic science, medicine, and pathology
Gunshot wounds (GSW) pose serious risks to both mother and fetus. Determining the trajectory and cause of death in the fetus in GSW is of forensic importance. This study aims to contribute to the literature with two rare GSW cases leading…
View details →Lu, Wang, Chen et al. · 2026 · Cell death discovery
Proper oocyte maturation is critical for female fertility, yet whether cuproptosis, a recently identified copper-dependent cell death pathway, affects meiotic maturation remains unknown. Here, we show that Cu(II)-elesclomol (ELC-Cu(II))…
View details →Walther, Hänel, Krohn et al. · 2026 · International journal of sports physiology and performance
To compare effects of block periodization against evenly distributed low-intensity training on endurance performance in well-trained junior cross-country (XC) skiers. Twenty junior cross-country skiers participated in a crossover design…
View details →Gu, Wen, Liu et al. · 2026 · Circulation
Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion (ie, Na + /H + and Ca 2 + ) cycling underlies reduced cardiac contractility. The…
View details →Srimanan, Sawangsribanterng, Poolsawat et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a classic neuro-ophthalmologic syndrome caused by disruption of the medial longitudinal fasciculus (MLF), resulting in impaired adduction of the affected eye and abducting nystagmus of the…
View details →Patel, Patel · 2026 · Cureus
Chronic pain is a complex phenomenon whose assessment involves not only physiological but also psychological and social components. Due to its subjective and variable nature, accurately measuring chronic pain remains challenging in both…
View details →Songthap, Wanaratwichit, Mekrungrongwong · 2026 · BMC public health
Despite existing efforts, premarital sex among Thai adolescents remains a critical public health concern, exacerbated by nearly universal smartphone access and prolonged daily digital exposure. Traditional surveillance often fails to…
View details →Cruciani, Cafaro, Perricone et al. · 2026 · Clinical and experimental rheumatology
This study aimed to compare different treatment strategies for rheumatoid arthritis (RA) patients following inadequate response to initial methotrexate (MTX) therapy, evaluating clinical outcomes, tolerability profiles, and factors…
View details →Zhang, Wei, Wu et al. · 2026 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Alcohol-associated liver disease (ALD) progresses from steatosis to steatohepatitis, but the underlying mechanisms remain unclear. Here, we investigated SETDB1's role in ALD progression involving LC3B-mediated LC3-associated phagocytosis…
View details →Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…
View details →Mizuno, Chretien, Nishida et al. · 2026 · Journal of gastroenterology
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), including cholangitis, a rare but clinically severe hepatobiliary phenotype. Whether potassium-competitive acid blockers (PCABs) such as vonoprazan are…
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