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Browse the failure-mode index

20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Association between Intraoperative Blood Pressure Drop and Clinically Significant Hypoperfusion in Abdominal Surgery: A Cohort Study

Zbigniew Putowski, Szymon Czajka, Łukasz J. Krzych · 2021 · Journal of Clinical Medicine

The recent consensus by the Perioperative Quality Initiative (POQI) on intraoperative hypotension (IOH) stated that mean arterial pressure (MAP) below 60–70 mmHg is associated with myocardial infarction (MI), acute kidney injury (AKI),…

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Negative / Null Result Report

An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change

Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig et al. · 2024 · JCPP Advances

Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in…

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Negative / Null Result Report

Incidence and time trends of herpes zoster among patients with head and neck cancer who did and did not undergo radiotherapy: A population-based cohort study

Peng-Yi Lee, Jung-Nien Lai, Lu-Ting Chiu et al. · 2021 · PLOS ONE

Purpose This study aimed to determine the risk and time trends of herpes zoster among patients with head and neck cancer, with or without radiotherapy. Methods A total of 2160 patients with head and neck cancer were enrolled. The…

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Negative / Null Result Report

Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature

Sara Redenšek Trampuž, David Vogrinc, Katja Goričar et al. · 2023 · Frontiers in Molecular Neuroscience

Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with…

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Negative / Null Result Report

Does SLOPE outperform bridge regression?

Shuaiwen Wang, Haolei Weng, Arian Maleki · 2021 · Information and Inference: A Journal of the IMA

Abstract A recently proposed SLOPE estimator [6] has been shown to adaptively achieve the minimax $\ell _2$ estimation rate under high-dimensional sparse linear regression models [25]. Such minimax optimality holds in the regime where the…

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Negative / Null Result Report

Education Finance Reform and the Great Recession: Did State Policy and Fiscal Federalism Improve Education Spending, School Resources, and Student Achievement in Pennsylvania?

Matthew P. Steinberg, Rand Quinn, J. Cameron Anglum · 2020 · Journal of Education Finance

abstract: We estimate the impact of school finance reform on adequate and equitable district spending, school resources and student achievement in Pennsylvania. From the 2008-09 to the 2010-11 school years, amid the Great Recession,…

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Negative / Null Result Report

ReplicOpter: A replicate optimizer for flexible docking

Omar N. A. Demerdash, Amanda Buyan, Julie C Mitchell · 2010 · Proteins: Structure, Function, and Bioinformatics

Abstract We present a computationally efficient method for flexible refinement of docking predictions that reflects observed motions within a protein's structural class. Using structural homologs, we derive deformation models that capture…

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Negative / Null Result Report

Can masked synonym priming replicate masked translation priming?

Naoko Witzel · 2019 · Quarterly Journal of Experimental Psychology

This study examines whether synonyms are represented similarly to translation equivalents in the bilingual mind. In particular, this study investigated whether there is masked synonym priming such that it will simulate masked translation…

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Negative / Null Result Report

Who did what to whom, and what did we already know?

Tania Ionin, Maria Goldshtein, Tatiana Luchkina et al. · 2021 · Linguistic Approaches to Bilingualism

Abstract This paper reports on an experimental investigation of what second language (L2) learners and heritage speakers of Russian know about the relationship between word order and information structure in Russian. The participants…

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Negative / Null Result Report

Did School Meal Programs and SNAP Participation Improve Diet Quality of US Children from Low-Income Households: Evidence from NHANES 2013–2014?

Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients

Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…

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Negative / Null Result Report

No significant difference between Australian heat wave impacts of Modoki and eastern Pacific El Niño

Tammas F. Loughran, Sarah E. Perkins‐Kirkpatrick, Lisa V. Alexander et al. · 2017 · Geophysical Research Letters

Abstract The influence of two El Niño types on the frequency of summer heat wave days in Australia is investigated using both observations and an atmospheric climate model. The two basic spatial variants of El Niño are the traditional…

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Negative / Null Result Report

The Continuous Fragility Index of Statistically Significant Findings in Studies Based on High Levels of Evidence Comparing Interventions for Femoroacetabular Impingement Syndrome

Juan Bernardo Villarreal-Espinosa, Zeeshan A. Khan, Kyleen Jan et al. · 2025 · The American Journal of Sports Medicine

Background: Critical analysis of studies with high level of evidence has relied on the significance set by the reported P values. However, this strategy steers readers toward categorical interpretation of the data; therefore, a more…

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Negative / Null Result Report

Extracting statistically significant eddy signals from large Lagrangian datasets using wavelet ridge analysis, with application to the Gulf of Mexico

Jonathan M. Lilly, Paula Pérez-Brunius · 2021 · Nonlinear Processes in Geophysics

Abstract. A method for objectively extracting the displacement signals associated with coherent eddies from Lagrangian trajectories is presented, refined, and applied to a large dataset of 3770 surface drifters from the Gulf of Mexico. The…

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Negative / Null Result Report

A Meta-Epidemiological Study of Positive Results in Clinical Nutrition Research: The Good, the Bad and the Ugly of Statistically Significant Findings

Konstantinos Gkiouras, Maria-Eleftheria Choleva, Aikaterini Verrou et al. · 2022 · Nutrients

Positive (statistically significant) findings are easily produced in nutrition research when specific aspects of the research design and analysis are not accounted for. To address this issue, recently, a pledge was made to reform nutrition…

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