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Browse the failure-mode index

19,815 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Less risk of patellofemoral degeneration without significant clinical and survivorship difference for distal tibial tuberosity high tibial osteotomy compared to biplanar high tibial osteotomy over a mid-term follow-up

Ke Li, Hengbing Guo, Fenglong Sun et al. · 2024 · Journal of Orthopaedic Surgery

Purpose This study aims to compare the mid-term radiographic, clinical results and survivorship between distal tibial tuberosity high tibial osteotomy (DTT-HTO) and conventional biplanar medial open-wedge high tibial osteotomy (cOW-HTO).…

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Negative / Null Result Report

Significant Differences and Experimental Designs Do Not Necessarily Imply Clinical Relevance: Effect Sizes and Causality Claims in Antidepressant Treatments

Iván Sánchez-Iglesias, Celia Martín-Aguilar · 2023 · Journal of Clinical Medicine

Clinical trials are the backbone of medical scientific research. However, this experimental strategy has some drawbacks. We focused on two issues: (a) The internal validity ensured by clinical trial procedures does not necessarily allow…

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Negative / Null Result Report

A real life retrospective analysis of drug expenditure reveals no significant cost difference between infliximab and adalimumab in the treatment of adult crohn's disease: Figure 1

C A Lamb, M Price, M Robinson et al. · 2011 · Gut

Introduction The revised NICE guidance on the use of infliximab and adalimumab for the treatment of Crohn's disease, released in May 2010, has suggested biologics be prescribed as a planned therapy until treatment failure or until…

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Negative / Null Result Report

ANALISIS KEMAMPUAN CALON GURU DALAM MENGEMBANGKAN MEDIA PEMBELAJARAN

Ines Tasya Jadidah, Eby Sania Awalia, Althaafi Abdillah et al. · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary

Tujuan penelitian ini dilakukan agar dapat menganalisa kemampuan calon guru dalam mengembangkan media pembelajaran. Penelitian ini menggunakan penelitian kualitatif deskrpitif yang intrumen nya berupa observasi untuk memperoleh suatu…

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Negative / Null Result Report

Did an Intervention Programme Aimed at Strengthening the Maternal and Child Health Services in Nigeria Improve the Completeness of Routine Health Data Within the Health Management Information System?

Benjamin Uzochukwu, Tolib Mirzoev, Chinyere Okeke et al. · 2020 · International Journal of Health Policy and Management

Background: During 2012-2015, the Federal Government of Nigeria launched the Subsidy Reinvestment and Empowerment Programme, a health system strengthening (HSS) programme with a Maternal and Child Health component (Subsidy Reinvestment and…

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Negative / Null Result Report

A single session of a beach volleyball exergame did not improve state anxiety level in healthy adult women

Vinnycius Nunes de Oliveira, Ricardo Borges Viana, João Victor Rosa de Freitas et al. · 2024 · BMC Sports Science, Medicine and Rehabilitation

Abstract This study evaluated the acute effect of the exergame Kinect Sports ® beach volleyball on state anxiety level in adult women. Thirty healthy adult women (age: 21 [4] years, body mass: 54.70 [19.50] kg, height: 1.61 ± 0.05 m, and…

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Negative / Null Result Report

Abstract 16996: Controlled Pauses (“Stutter”) CPR Did Not Improve ROSC or 4-hour Survival in a Porcine Model of VF-induced Cardiac Arrest

Alexander Esibov, Tyson G Taylor, Sharon B Melnick et al. · 2015 · Circulation

Introduction: Ischemic post-conditioning (IPC) has shown promise in mitigating ischemia-reperfusion injury. Controlled pauses during CPR (CP-CPR) following cardiac arrest (CA) and prolonged downtime may help invoke IPC mechanisms and have…

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Negative / Null Result Report

When biology takes over: TV formats like The Bachelor and The Bachelorette confirm evolutionary theories of partner selection

Alexandra Lenhard, Marie-Pierre Minten, Wolfgang Lenhard · 2023 · Frontiers in Psychology

Introduction In this study, we investigated the impact of age on mate selection preferences in males and females, and explored how the formation and duration of committed relationships depend on the sex of the person making the selection.…

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Negative / Null Result Report

A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy

Ruilin Xiong, Wei Wang, Xianwen Shang et al. · 2023 · Therapeutic Advances in Ophthalmology

Background: Diabetic retinopathy, a common microvascular complication of diabetes mellitus, is one of the leading causes of vision loss worldwide. Although some oral drugs have been suggested to affect the risk of diabetic retinopathy,…

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Negative / Null Result Report

No Significant Association Between Vitamin C Supplements and Frailty in Korean Older Adults: A Cross-Sectional Analysis of the 2018–2019 Korea National Health and Nutrition Examination Survey

Seung Guk Park, Hyoeun Kim · 2025 · Nutrients

Background/Objectives: The association between vitamin C intake and frailty among older adults remains unclear, and evidence from Asian populations is limited. Using nationally representative data, we aimed to examine whether vitamin C…

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Negative / Null Result Report

Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool

Sehoon Park, Yisak Kim, Chung Hee Baek et al. · 2025 · Kidney Research and Clinical Practice

Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using…

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Negative / Null Result Report

Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer*

Shaojun Nong, Yangbo Guan, Zhiwei Wang et al. · 2019 · Oncology and Translational Medicine

Abstract Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4 (OCT4) and interleukin-18 (IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene…

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