Negative / Null Result Report
A. Archidona-Yuste, I. Clavero-Camacho, A. N. Ruiz-Cuenca et al. · 2024 · Zoological Letters
Abstract The ring nematode genus Xenocriconemella De Grisse and Loof, 1965 comprises only one nominal species, Xenocriconemella macrodora (Taylor, 1936) De Grisse and Loof, 1965. The initial objective of the present study was to…
View details →Negative / Null Result ReportPsychology
Kory Floyd, Nathan T. Woo · 2020 · Personal Relationships
Abstract Contrary to the claim that loneliness routinely impairs the decoding of social cues such as emotion displays, Knowles, Lucas, Baumeister, and Gardner (2015) proposed that lonely adults “choke under pressure,” experiencing…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Andrew J. Steward, Daniel J. Kelly, Diane R. Wagner · 2016 · Tissue Engineering Part A
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction of HP may form the basis for novel tissue engineering strategies.…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Lewend Mayiwar, Linda Lai · 2019 · Social Psychology
Abstract. We performed an independent, direct, and better powered ( N = 295) replication of Study 1, an experiment ( N = 113) by Lammers, Stoker, and Stapel (2009) . Lammers and colleagues distinguished between social power (influence over…
View details →Negative / Null Result ReportOpen accessMedicine
Hisayuki Katsuyama, Hidekatsu Yanai, Hiroki Adachi et al. · 2023 · Gastroenterology Research
Background: We previously reported that the selective peroxisome proliferator-activated receptor alpha modulator, pemafibrate, significantly reduced serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and…
View details →Negative / Null Result ReportOpen accessMedicine
Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng et al. · 2022 · The Indian Journal of Medical Research
Background & objectives Polio, measles, rubella, influenza and rotavirus surveillance programmes are of great public health importance globally. Virus isolation using cell culture is an integral part of such programmes. Possibility of…
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Devika Sindu, Deepika Razia, Katherine Grief et al. · 2023 · Transplantation Direct
Background. Lung transplant recipients (LTRs) have an increased risk of COVID-19–related morbidity and mortality. Tixagevimab-cilgavimab (tix-cil) is a long-acting monoclonal antibody combination granted Emergency Use Authorization…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaolin Yu, Jie Zhu, Xiang‐meng Liu et al. · 2020 · British Journal of Pharmacology
BACKGROUND AND PURPOSE: Immunotherapeutic intervention is one of the most promising strategies for the prevention and treatment of Alzheimer's disease (AD). Although they showed great success in AD mouse models, the clinical trials of many…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sk. Kayum Alam, Li Wang, Zhu Zhu et al. · 2023 · npj Precision Oncology
Non-small cell lung cancer (NSCLC) accounts for 80-85% cases of lung cancer cases. Diagnosis at advanced stages is common, after which therapy-refractory disease progression frequently occurs. Therefore, a better understanding of the molecular mechanisms that control NSCLC progression is necessary to develop new therapies. Overexpression of IκB kinase α (IKKα) in NSCLC correlates with poor patient survival. IKKα is an NF-κB-activating kinase that is important in cell survival and differentiation, but its regulation of oncogenic signaling is not well understood. We recently demonstrated that IK
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Rebecca D. Dodd, Amanda Scherer, Wesley Huang et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New…
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H. R. Spaulding, T. Quindry, J. C. Quindry et al. · 2020 · Experimental Physiology
New Findings What is the central question of this study? We previously demonstrated that quercetin transiently preserved respiratory function in dystrophin‐deficient mice. To gain lasting therapeutic benefits, we tested quercetin in…
View details →Negative / Null Result ReportOpen accessMedicine
Adrian K. Davison, Graham Dinsdale, Paul New et al. · 2022 · Rheumatology Advances in Practice
Objective: Clinical trials assessing systemic sclerosis (SSc)-related digital ulcers have been hampered by a lack of reliable outcome measures of healing. Our objective was to assess the feasibility of patients collecting high-quality mobile phone images of their digital lesions as a first step in developing a smartphone-based outcome measure. Methods: Patients with SSc-related digital (finger) lesions photographed one or more lesions each day for 30 days using their smartphone and uploaded the images to a secure Dropbox folder. Image quality was assessed using six criteria: blurriness, shadow
View details →Negative / Null Result ReportOpen accessMedicine
Vasileios Angelis, Alicia Okines · 2023 · Cancers
Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase in
View details →Negative / Null Result ReportOpen accessMedicine
Lujun Shen, Fei Cao, Ying Liu et al. · 2025 · BMC Medicine
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) stage C…
View details →Negative / Null Result ReportMedicine
Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research
AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…
View details →Negative / Null Result ReportOpen accessMedicine
Jwa Hoon Kim, Jae Ho Jeong, Baek‐Yeol Ryoo et al. · 2020 · Cancer Research and Treatment
PURPOSE: This study evaluated the efficacy of adjuvant chemotherapy (AC) in patients with resected ampulla of Vater (AoV) carcinoma. MATERIALS AND METHODS: Data from 646 patients who underwent surgical resection at Asan Medical Center…
View details →Negative / Null Result ReportOpen accessMedicine
S. Lot Aronson, Bram Thijssen, Marta López‐Yurda et al. · 2025 · Nature Communications
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in high-grade serous ovarian cancer (HGSOC) remains limited. Some patients, however, achieve lasting responses, emphasizing the need to…
View details →Negative / Null Result ReportOpen accessMedicine
Sha Sha, Lina Ren, Xiaona Xing et al. · 2025 · Neural Regeneration Research
Alzheimer's disease, a devastating neurodegenerative disorder, is characterized by progressive cognitive decline, primarily due to amyloid-beta protein deposition and tau protein phosphorylation. Effectively reducing the cytotoxicity of…
View details →Negative / Null Result ReportOpen accessMedicine
Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology
PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…
View details →Negative / Null Result ReportOpen accessMedicine
Louis Pechmajou, Éloi Marijon, Olivier Varenne et al. · 2020 · Circulation Cardiovascular Interventions
Background: Conflicting data exist regarding the benefit of urgent coronary angiogram and percutaneous coronary intervention (PCI) after sudden cardiac arrest, particularly in the absence of ST-segment elevation. We hypothesized that the…
View details →Negative / Null Result ReportOpen accessMedicine
Adam Brufsky, Michael T. Lotze · 2020 · Journal of Medical Virology
Muller's ratchet1 predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms.2 In cell culture, serial passage of genetically bottlenecked vesicular stomatitis virus, which grew quite rapidly on HeLa cells, severely reduced in fitness and virulence within 20 passages in a novel BHK host cell.2 Genetic bottlenecks are likely important in intraspecies viral transmission.3 RNA-based viruses are particularly prone to repeated bottlen
View details →Negative / Null Result ReportMedicine
Leah Amundson, Brandon Boelts, Vivek Kataria et al. · 2021 · Infectious Diseases in Clinical Practice
To the Editor: Coronavirus disease 2019 (COVID-19) has resulted in a widespread pandemic in which various therapeutics have been studied. Targeted therapies focus on either the viral or the inflammatory phase to ultimately reduce disease…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences
Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention
View details →Negative / Null Result ReportOpen accessMedicine
Lucy Plumb, Anna Casula, Manish D. Sinha et al. · 2023 · Clinical Kidney Journal
ABSTRACT Background Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study…
View details →Negative / Null Result ReportOpen accessMedicine
Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…
View details →Negative / Null Result Report
M. Müllner, K. Zwintz, E. Corsaro et al. · 2021 · Astronomy & Astrophysics
Context. In recent years, our understanding of solar-like oscillations from main sequence to red giant stars has improved dramatically thanks to pristine data collected from space telescopes. One of the remaining open questions focuses on…
View details →Negative / Null Result Report
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
View details →Negative / Null Result Report
Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening
Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…
View details →Negative / Null Result Report
Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research
The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…
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