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20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessPhysics and Astronomy

The Multiwavelength Context of Delayed Radio Emission in Tidal Disruption Events: Evidence for Accretion-driven Outflows

K. D. Alexander, R. Margutti, Sebastian Gomez et al. · 2026 · The Astrophysical Journal

Abstract Recent observations presented in Y. Cendes et al. show that optically selected tidal disruption events (TDEs) commonly produce delayed radio emission that can peak years after disruption. Here, we explore the multiwavelength properties of a sample of radio-observed optically selected TDEs, to shed light on the physical process(es) responsible for the late-rising radio emission. We combine new late-time X-ray observations with archival optical, UV, X-ray, and radio data to conclude that a diversity of accretion-driven outflows may power the delayed radio emission in TDEs. Our analysis

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Negative / Null Result ReportOpen accessDecision Sciences

Enhancing the Ethical Culture of Organizations: A Longitudinal Study Using a Comprehensive Ethics Training

Pablo Ruiz‐Palomino, Juliana Toro‐Arias, María del Pilar Rodríguez‐Córdoba et al. · 2025 · Business Ethics the Environment & Responsibility

ABSTRACT A supportive ethical culture (EC) can encourage moral behavior among employees and help them avoid wrongdoing. One option for fostering EC is ethics training; its longer‐term effectiveness, however, has rarely been examined,…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

A comparison of computational methods for expression forecasting

Eric Kernfeld, Yunxiao Yang, Joshua S. Weinstock et al. · 2025 · Genome biology

Diverse machine learning methods promise to forecast gene expression changes in response to novel genetic perturbations. However, these methods' accuracy is not well characterized. We created a benchmarking platform that combines a panel…

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Negative / Null Result ReportOpen accessEngineering

Facile Construction of Eco-friendly Chitosan-Based Supramolecular Hydrogels as Pesticide Delivery Systems for Plant Growth Regulation and Antifungal Applications

Yu‐Hui Zhang, Lu-Qiang Wei, Chen-Shuang Liu et al. · 2025 · ACS Omega

High Resolution Image Download MS PowerPoint Slide Pesticides are of great significance in ensuring food yield. However, the extensive use of pesticides has led to severe environmental pollution and significant economic losses.…

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Negative / Null Result ReportOpen accessEngineering

A High-Temperature, High-Voltage SOI Gate Driver IC with High Output Current and On-Chip Low-Power Temperature Sensor

M. A. Huque, Leon M. Tolbert, Benjamin J. Blalock et al. · 2026 · IMAPSource Proceedings

High-temperature power conversion modules (DC-DC converters, inverters, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. Power-to-volume and…

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Negative / Null Result ReportOpen accessPsychology

On the universality of aesthetic preference and inference: a cross-cultural (Chinese–German) study

Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications

Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

FinTech Investment, Geopolitical-Economic Uncertainty, and CO2 Emissions in Low- and Middle-Income Countries: Evidence from Dynamic Panel Models

Nurcan Kilinc‐Ata, Alia Al-Fori · 2026 · Journal of risk and financial management

The intersection of financial innovation and environmental sustainability offers important opportunities for low- and middle-income (LMI) countries. This study examines the association between FinTech investment, geopolitical-economic uncertainty, urbanization, economic development, and carbon dioxide (CO2) emissions in LMI countries. CO2 emissions per capita are used as an environmental outcome indicator rather than as a direct measure of green finance. Using a panel dataset covering 2010–2021, the study applies fixed-effects panel regressions as the main empirical approach and reports one-st

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Negative / Null Result ReportOpen accessMedicine

Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis

Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research

Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…

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Negative / Null Result ReportOpen accessEnvironmental Science

Vegetarian diets and cancer risk: pooled analysis of 1.8 million women and men in nine prospective studies on three continents

Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling et al. · 2026 · British Journal of Cancer

BACKGROUND: Vegetarian diets might influence cancer risk. METHODS: We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Oncolytic Viruses in Cancer Immunotherapy: From Molecular Engineering to Clinical Translation

Mohammad Fayyad‐Kazan, Sarah Ayad Al-Tameemi, Allal Ouhtit · 2026 · Cells

Cancer immunotherapy has transformed modern oncology, yet durable responses remain limited for many patients due to immune exclusion, adaptive resistance, and tumor heterogeneity. Oncolytic viruses (OVs) have emerged as a novel class of immunotherapeutics that unify direct tumor cytolysis with stimulation of antitumor immunity. By inducing immunogenic cell death (ICD) and releasing tumor-associated antigens (TAAs), OVs remodel the tumor microenvironment (TME) into an inflamed and immune-permissive niche capable of enabling systemic immune activation. Rapid advances in viral engineering have st

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Negative / Null Result ReportOpen accessMedicine

Precision Medicine in Asthma: The Role of Biomarkers

Eleanor Quek, Neve Horn, Salman Siddiqui · 2025 · ImmunoTargets and Therapy

Asthma represents a profoundly heterogeneous syndrome underpinned by multiple, distinct and overlapping immunopathological mechanisms. Nevertheless, prevailing management algorithms continue to adopt a largely uniform, stepwise approach in…

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Negative / Null Result ReportOpen accessMedicine

The impact of PEEP-guided electrical impedance tomography on oxygenation and respiratory mechanics in moderate-to-severe ARDS: a randomized controlled trial

Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports

Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…

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Negative / Null Result ReportOpen accessComputer Science

The role of data augmentation and attention mechanisms in UNet and ConvNeXt architectures for optimizing breast tumor segmentation

Mohammadreza Kamsari, Soroush Sadeghi, Gabriel Gomes de Oliveira et al. · 2025 · Scientific Reports

This study conducts a comprehensive analysis of various configurations of the UNet + ConvNeXt Tiny architecture for breast tumor segmentation. We assess the influence of data augmentation, skip connections, attention mechanisms, and…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum

Fereshteh Bakhshalipoor, Marzieh Bolandi, Fariborz Nahidi et al. · 2026 · Scientific Reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

The Steep Redshift Evolution of the Hierarchical Binary Black Hole Merger Rate May Cause the z - χ eff Correlation

A. M. Farah, A. Vijaykumar, M. Fishbach · 2026 · The Astrophysical Journal Letters

Abstract There is growing evidence from gravitational-wave (GW) observations that some merging black holes (BHs) are created from previous mergers. Using the prediction that these hierarchically merged BHs have dimensionless spin magnitudes of χ ≈ 0.69, we identify a subpopulation in the GW data consistent with a hierarchical-merger origin in dense star clusters. This subpopulation’s primary mass distribution peaks at 17 . 0 − 4.4 + 18.3 M ⊙ , which is approximately twice as large as its secondary mass distribution’s mode ( 10 . 5 − 4.7 + 29.7 M ⊙ ), and its spin tilt distribution is consisten

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Negative / Null Result ReportOpen accessMedicine

Parkinson's disease: pathogenesis and therapeutic strategies

Shanshan Zhang, Tingyu Wang, Ye Peng et al. · 2026 · Molecular Biomedicine

Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairments such as bradykinesia, tremor, and rigidity. Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues. The etiology of PD is multifactorial, involving a complex interplay of genetic predisposition, aging, environmental exposures, and lifestyle factors. Disease pathogenesis

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Negative / Null Result ReportMedicine

High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure

Jean-Pierre Frat, J. Quenot, Christophe Guitton et al. · 2026 · New England Journal of Medicine

BACKGROUND: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. METHODS: In this…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Root traits and mycorrhizal fungi mediate reactive N and warming impacts on soil organic carbon

Yunpeng Qiu, Yunfeng Zhao, Bianbian Wang et al. · 2026 · Nature Communications

Plant roots and arbuscular mycorrhizal fungi (AMF) form a ubiquitous symbiosis in terrestrial ecosystems and critically affect soil organic carbon (SOC) dynamics. However, how roots and AMF mediate the impact of reactive nitrogen (Nr) and…

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Negative / Null Result ReportOpen accessSocial Sciences

The impact of AI anxiety on career decisions of college students

Ninggui Duan, Lina Li, Guangbo Lin et al. · 2026 · Scientific Reports

The rapid advancement of artificial intelligence (AI) has reshaped the employment market, triggering widespread anxiety among college students about their future careers and posing a potential threat to their career decisions. Grounded in…

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Negative / Null Result ReportOpen accessChemistry

Catalytic Oxidative Ligand Transfer of Rh-Carbynoids and Alkyl Iodides

Josep Esteve Guasch, Debasis Pal, Marcos G. Suero · 2025 · Journal of the American Chemical Society

High Resolution Image Download MS PowerPoint Slide Herein, we disclose the first catalytic generation of alkyl–I (III) Rh (II) -carbynoids via oxidative ligand transfer between alkyl iodides and aryl–I (III) Rh (II) -carbynoids. When homoallylic iodides were used, alkyl–I (III) Rh (II) -carbynoids evolved through a diastereoselective cyclopropanation that led to highly electrophilic bicyclic alkyl–I (III) species. We observed that the latter species reacted with a plethora of nucleophiles, enabling access to a valuable class of cyclopropanes that were converted to housanes.

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Negative / Null Result ReportOpen accessPhysics and Astronomy

Indirect searches for dark photon-photon tridents in celestial objects

Tim Linden, Thong T. Q. Nguyen, Tim M. P. Tait · 2026 · Journal of Cosmology and Astroparticle Physics

Abstract We model and constrain the unique indirect detection signature produced by dark matter particles that annihilate through a U(1) gauge symmetry into dark photons that subsequently decay into three-photon final states. We focus on scenarios where the dark photon is long-lived, and show that γ-ray probes of celestial objects can set strong constraints on the dark matter/baryon scattering cross section that in many cases surpass the power of current direct detection constraints, and in some cases even peer into the neutrino fog.

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Negative / Null Result ReportOpen accessMedicine

Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors

Brenda M O'Neill, Judy Martina Bradley, Bronwen A. Connolly et al. · 2026 · JAMA

Importance: Evidence for remote multicomponent rehabilitation among critical care survivors is sparse. Objective: To investigate the effects of a 6-week, remote, multicomponent rehabilitation intervention in survivors of critical illness following discharge from the hospital after an intensive care unit (ICU) admission compared with standard care on health-related quality of life at 8 weeks. Design, Setting, and Participants: Pragmatic, multicenter, assessor-blinded, randomized clinical trial conducted from December 2022 to November 2025 at 52 National Health Service hospitals in the UK. Parti

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Negative / Null Result ReportOpen accessPhysics and Astronomy

REBELS-IFU: evidence for metal-rich massive galaxies at z ∼ 6−8

Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society

ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Bridging digital innovation and energy justice: The role of artificial intelligence in advancing energy equity

Oxana Kirichok, Yuliia Orlovska, G.S. Zhanseitova et al. · 2025 · Environmental Economics

Type of the article: Research ArticleAbstract Global progress toward universal access to affordable, reliable, and clean energy has stalled, with over two billion people still lacking access to clean cooking, and affordability pressures are rising. AI is emerging as an energy-intensive technology and a potential enabler of more equitable energy systems. This paper assesses whether AI vibrancy contributes to advancing energy equity across countries while accounting for differences in economic capacity. The study employs a balanced panel of 36 countries from 2017 to 2023 (252 observations), draw

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

From Fossil Dependence on Sustainability: The Effects of Energy Transition, Green Growth, and Financial Inclusion on Environmental Degradation in the MENA Region

Sami S. Omar, Wagdi M. S. Khalifa, Tolga Öz · 2025 · Energies

Amid growing environmental concerns and an increasing push for sustainable development, countries in the Middle East and North Africa (MENA) region have taken proactive steps toward green growth, energy transition, and technological innovation. As a result, this study examines the effects of green growth, energy transition, technological innovation, financial inclusion, and urbanization on environmental sustainability in the Middle East and North Africa (MENA) region. Moreover, this study breaks new ground by exposing the hidden environmental costs of financial inclusion, urbanization, and tec

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Reconciling fiscal decentralization, environmental protection expenditures, and stringent regulations with the ecological priorities of the European Union

Elma Šatrović, Oluwatoyin Abidemi Somoye, Banji Rildwan Olaleye et al. · 2025 · Frontiers in Environmental Science

This study elucidates how fiscal decentralization affects environmental sustainability, moderating the role of environmental policy stringency in the selected European Union (EU) countries between 1995 and 2020. In addition, economic upturn, import diversification, and environmental protection expenditures are utilized as control variables. The empirical findings of the Method of the Moments Quantile Regression (MMQR) disclosed that the environmental policy stringency and environmental protection expenditures help the EU achieve ecological priorities. In addition, import diversification also s

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Negative / Null Result ReportOpen accessSocial Sciences

Drivers of Labor Force Participation and Economic Growth in Gulf Cooperation Countries Region: A Dynamic Panel Analysis

Ihsen Abid · 2025 · International Journal of Sustainable Development and Planning

This study investigates the drivers of labor force participation and GDP growth in the Gulf Cooperation Council (GCC) region from 1990 to 2023, emphasizing the roles of youth employment, urbanization, export performance, and foreign direct investment (FDI).Using the Arellano-Bond dynamic panel data estimation method, the study models interdependent relationships between labor force participation, GDP growth, and key macroeconomic indicators while addressing endogeneity and dynamic feedback effects.The analysis reveals that lagged labor force participation has a strong positive and highly signi

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